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TAS2R40 taste 2 receptor member 40 [ Homo sapiens (human) ]

Gene ID: 259286, updated on 5-Mar-2024

Summary

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Official Symbol
TAS2R40provided by HGNC
Official Full Name
taste 2 receptor member 40provided by HGNC
Primary source
HGNC:HGNC:18885
See related
Ensembl:ENSG00000221937 MIM:613964; AllianceGenome:HGNC:18885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR60; T2R40; T2R58
Summary
This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. A decrease in the expression of this gene is associated with hypogeusia. [provided by RefSeq, Jul 2017]
Orthologs
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Genomic context

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See TAS2R40 in Genome Data Viewer
Location:
7q34
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (143222037..143223079)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (144577457..144578499)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (142919130..142920172)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene taste 2 receptor member 39 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26790 Neighboring gene uncharacterized LOC124901764 Neighboring gene uncharacterized LOC105375546 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:142943994-142944170 Neighboring gene TMEM139 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18719 Neighboring gene Sharpr-MPRA regulatory region 7901 Neighboring gene glutathione S-transferase kappa 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Patients with hypogeusia show changes in expression of T2R taste receptor genes in their tongues. Onoda K, et al. Laryngoscope, 2011 Dec. PMID 22109758
  2. Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol. Thalmann S, et al. Biochem Biophys Res Commun, 2013 May 31. PMID 23632330
  3. Identification and characterization of human taste receptor genes belonging to the TAS2R family. Conte C, et al. Cytogenet Genome Res, 2002. PMID 12584440
  4. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Bufe B, et al. Nat Genet, 2002 Nov. PMID 12379855
  5. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Go Y, et al. Genetics, 2005 May. PMID 15744053, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of taste receptor, type 2, member 40 (TAS2R40) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC126844, MGC126846

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables bitter taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bitter taste receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of bitter taste IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of chemical stimulus involved in sensory perception of bitter taste IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IC
Inferred by Curator
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
taste receptor type 2 member 40
Names
G-protein coupled receptor 60
taste receptor type 2 member 58
taste receptor, type 2, member 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176882.2 → NP_795363.1  taste receptor type 2 member 40

    See identical proteins and their annotated locations for NP_795363.1

    Status: REVIEWED

    Source sequence(s)
    BC101795
    Consensus CDS
    CCDS43662.1
    UniProtKB/Swiss-Prot
    A4D2I2, P59535, Q645W6
    UniProtKB/TrEMBL
    Q50KK6
    Related
    ENSP00000386210.3, ENST00000408947.4
    Conserved Domains (1) summary
    cd15014
    Location:19 → 308
    7tm_TAS2R40; mammalian taste receptor 2, subtype 40, member of the seven-transmembraneG-protein coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    143222037..143223079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    144577457..144578499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59535.1 GenPept UniProtKB/Swiss-Prot:P59535

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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