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Tubgcp3 tubulin, gamma complex component 3 [ Mus musculus (house mouse) ]

Gene ID: 259279, updated on 11-Apr-2024

Summary

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Official Symbol
Tubgcp3provided by MGI
Official Full Name
tubulin, gamma complex component 3provided by MGI
Primary source
MGI:MGI:2183752
See related
Ensembl:ENSMUSG00000000759 AllianceGenome:MGI:2183752
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GCP3; Spc98p
Summary
Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Predicted to be located in centriole; cytoplasm; and polar microtubule. Predicted to be part of gamma-tubulin small complex. Predicted to be active in centrosome and equatorial microtubule organizing center. Is expressed in metanephros and thymus primordium. Orthologous to human TUBGCP3 (tubulin gamma complex associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 15.7), liver E14.5 (RPKM 14.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A1.1; 8 5.73 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (12664277..12722141, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (12614277..12672854, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20743 Neighboring gene predicted gene, 53397 Neighboring gene STARR-seq mESC enhancer starr_20744 Neighboring gene sperm acrosome associated 7 Neighboring gene STARR-seq mESC enhancer starr_20746 Neighboring gene RIKEN cDNA 4931415C17 gene Neighboring gene predicted gene 15348

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34. Vats KR, et al. J Am Soc Nephrol, 2006 Apr. PMID 16565260
  2. Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes. Gorini G, et al. FEBS Lett, 2010 Mar 5. PMID 20114047, Free PMC Article
  3. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
  4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gamma-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in equatorial microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
  
located_in polar microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gamma-tubulin complex component 3
Names
GCP-3
spindle pole body protein
tubulin, gamma complex associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198031.1 → NP_932148.1  gamma-tubulin complex component 3

    See identical proteins and their annotated locations for NP_932148.1

    Status: PROVISIONAL

    Source sequence(s)
    BC058566
    Consensus CDS
    CCDS22103.1
    UniProtKB/Swiss-Prot
    P58854, Q6PDQ9
    UniProtKB/TrEMBL
    Q3TAJ6
    Related
    ENSMUSP00000000776.9, ENSMUST00000000776.15
    Conserved Domains (1) summary
    pfam04130
    Location:251 → 761
    Spc97_Spc98; Spc97 / Spc98 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    12664277..12722141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508801.4 → XP_006508864.1  gamma-tubulin complex component 3 isoform X2

    Conserved Domains (2) summary
    pfam04130
    Location:145 → 476
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:1 → 142
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  2. XM_030243572.2 → XP_030099432.1  gamma-tubulin complex component 3 isoform X1

    Conserved Domains (2) summary
    pfam04130
    Location:288 → 619
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:2 → 285
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  3. XM_036154053.1 → XP_036009946.1  gamma-tubulin complex component 3 isoform X2

    Conserved Domains (2) summary
    pfam04130
    Location:145 → 476
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:1 → 142
    GCP_N_terminal; Gamma tubulin complex component N-terminal

  4. XM_036154054.1 → XP_036009947.1  gamma-tubulin complex component 3 isoform X2

    Conserved Domains (2) summary
    pfam04130
    Location:145 → 476
    Spc97_Spc98; Spc97 / Spc98 family
    pfam17681
    Location:1 → 142
    GCP_N_terminal; Gamma tubulin complex component N-terminal

RNA

  1. XR_004934826.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58854.2 GenPept UniProtKB/Swiss-Prot:P58854

Gene LinkOut

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