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GAK cyclin G associated kinase [ Homo sapiens (human) ]

Gene ID: 2580, updated on 3-Apr-2024

Summary

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Official Symbol
GAKprovided by HGNC
Official Full Name
cyclin G associated kinaseprovided by HGNC
Primary source
HGNC:HGNC:4113
See related
Ensembl:ENSG00000178950 MIM:602052; AllianceGenome:HGNC:4113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DNAJ26; DNAJC26
Summary
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in testis (RPKM 16.1), colon (RPKM 15.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
4p16.3
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (849277..932316, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (847030..930388, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (843065..926104, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:781743-782244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:782245-782744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:783251-783750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:784983-785792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21137 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:793259-793758 Neighboring gene complexin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:823745-824262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:824263-824778 Neighboring gene uncharacterized LOC105374340 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:860125-861324 Neighboring gene uncharacterized LOC105374341 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:872957-874156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:880593-881094 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:881095-881594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:905677-906582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:906583-907488 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:938924-939517 Neighboring gene transmembrane protein 175 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:957241-957400 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:961731-962444 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:962445-963158 Neighboring gene uncharacterized LOC124900645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:963506-964024 Neighboring gene diacylglycerol kinase theta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mutation Analysis of DNAJC Family for Early-Onset Parkinson's Disease in a Chinese Cohort. Li C, et al. Mov Disord, 2020 Nov. PMID 32662538
  2. Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic. He K, et al. J Cell Biol, 2020 Mar 2. PMID 31962345, Free PMC Article
  3. The 4p16.3 Parkinson Disease Risk Locus Is Associated with GAK Expression and Genes Involved with the Synaptic Vesicle Membrane. Nagle MW, et al. PLoS One, 2016. PMID 27508417, Free PMC Article
  4. The Potential Mutation of GAK Gene in the Typical Sporadic Parkinson's Disease from the Han Population of Chinese Mainland. Zhang J, et al. Mol Neurobiol, 2016 Dec. PMID 26676575
  5. Quantitative assessment of the association between GAK rs1564282 C/T polymorphism and the risk of Parkinson's disease. Ma ZG, et al. J Clin Neurosci, 2015 Jul. PMID 25975492

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GAK and PRKCD are positive regulators of PRKN-independent mitophagy.
    Title: GAK and PRKCD are positive regulators of PRKN-independent mitophagy.
  2. Mutation Analysis of DNAJC Family for Early-Onset Parkinson's Disease in a Chinese Cohort.
    Title: Mutation Analysis of DNAJC Family for Early-Onset Parkinson's Disease in a Chinese Cohort.
  3. Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury.
    Title: Inhibiting calpain 1 and 2 in cyclin G associated kinase-knockout mice mitigates podocyte injury.
  4. Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic.
    Title: Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic.
  5. These findings indicate that the abnormal mitoses seen after silencing OIP5-AS1 were caused by an untimely rise in GAK levels and suggest that OIP5-AS1 suppresses cell proliferation at least in part by reducing GAK levels.
    Title: LncRNA OIP5-AS1/cyrano suppresses GAK expression to control mitosis.
  6. that the multiple single nucleotide polymorphisms of GAK synergistically participate in the pathogenesis of sporadic Parkinson's disease through multiple pathways.
    Title: The Potential Mutation of GAK Gene in the Typical Sporadic Parkinson's Disease from the Han Population of Chinese Mainland.
  7. We have demonstrated that siRNA-mediated GAK silencing causes marked cell cycle disruption resulting in a raised sub-G1 alongside decreased G1 and G2/M cell cycle phases. Dual FBXW7-GAK inhibition increases multipolar mitoses
    Title: RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.
  8. GAK gene expression is increased in Parkinson disease
    Title: The 4p16.3 Parkinson Disease Risk Locus Is Associated with GAK Expression and Genes Involved with the Synaptic Vesicle Membrane.
  9. These results suggest that the c-Src_GAK_MCM axis plays an important role in cell cycle progression through control of the DNA replication licensing system.
    Title: GAK is phosphorylated by c-Src and translocated from the centrosome to chromatin at the end of telophase.
  10. We filtered four OSCC genes including SERPINB9, SERPINE2, GAK, and HSP90B1 through the gene global prioritization score (P < 0.005).
    Title: Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
EBI GWAS Catalog
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
EBI GWAS Catalog
Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
EBI GWAS Catalog
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
EBI GWAS Catalog
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
EBI GWAS Catalog
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with cyclin G associated kinase (GAK) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16629, FLJ40395, MGC99654

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Golgi to lysosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in chaperone cofactor-dependent protein refolding TAS
Traceable Author Statement
more info
 PubMed 
involved_in clathrin coat assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clathrin coat disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin coat disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of clathrin coat assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle uncoating ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclin-G-associated kinase
Names
auxilin-2
NP_001305063.1
NP_005246.2
XP_005272325.1
XP_005272327.1
XP_011511727.1
XP_011511728.1
XP_011511729.1
XP_011511730.1
XP_011511731.1
XP_011511732.1
XP_011511733.1
XP_011511734.1
XP_011511736.1
XP_016863480.1
XP_016863481.1
XP_016863482.1
XP_016863483.1
XP_047305958.1
XP_047305959.1
XP_047305960.1
XP_047305961.1
XP_047305962.1
XP_047305963.1
XP_047305964.1
XP_047305966.1
XP_047305967.1
XP_047305968.1
XP_047305969.1
XP_047305970.1
XP_047305971.1
XP_047305972.1
XP_047305974.1
XP_047305975.1
XP_047305976.1
XP_047305977.1
XP_047305978.1
XP_047305979.1
XP_047305980.1
XP_047305981.1
XP_047305982.1
XP_047305984.1
XP_047305985.1
XP_047305986.1
XP_047305987.1
XP_047305988.1
XP_047305989.1
XP_047305990.1
XP_047305991.1
XP_054205549.1
XP_054205550.1
XP_054205551.1
XP_054205552.1
XP_054205553.1
XP_054205554.1
XP_054205555.1
XP_054205556.1
XP_054205557.1
XP_054205558.1
XP_054205559.1
XP_054205560.1
XP_054205561.1
XP_054205562.1
XP_054205563.1
XP_054205564.1
XP_054205565.1
XP_054205566.1
XP_054205567.1
XP_054205568.1
XP_054205569.1
XP_054205570.1
XP_054205571.1
XP_054205572.1
XP_054205573.1
XP_054205574.1
XP_054205575.1
XP_054205576.1
XP_054205577.1
XP_054205578.1
XP_054205579.1
XP_054205580.1
XP_054205581.1
XP_054205582.1
XP_054205583.1
XP_054205584.1
XP_054205585.1
XP_054205586.1
XP_054205587.1
XP_054205588.1
XP_054205589.1
XP_054205590.1
XP_054205591.1
XP_054205592.1
XP_054205593.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318134.2 → NP_001305063.1  cyclin-G-associated kinase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three consecutive exons in the 5' coding region but maintains the same reading frame as variant 1. The encoded isoform (3) has the same N- and C-termini, but is shorter than isoform 1.
    Source sequence(s)
    AA287110, AI138676, AK299554, BC000816, BC085005
    Consensus CDS
    CCDS82902.1
    UniProtKB/TrEMBL
    B4DS37
    Related
    ENSP00000421361.1, ENST00000511163.5
    Conserved Domains (4) summary
    cd06257
    Location:1181 → 1225
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    smart00220
    Location:53 → 230
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam10409
    Location:491 → 629
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21453
    Location:46 → 241
    PKc_like; Protein Kinases, catalytic domain

  2. NM_005255.4 → NP_005246.2  cyclin-G-associated kinase isoform 1

    See identical proteins and their annotated locations for NP_005246.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA287110, AI138676, BC000816, D88435, DA680073
    Consensus CDS
    CCDS3340.1
    UniProtKB/Swiss-Prot
    O14976, Q5U4P5, Q9BVY6
    UniProtKB/TrEMBL
    B4DS37
    Related
    ENSP00000314499.4, ENST00000314167.9
    Conserved Domains (4) summary
    cd06257
    Location:1260 → 1304
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    smart00220
    Location:41 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14036
    Location:39 → 320
    STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
    pfam10409
    Location:570 → 708
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    849277..932316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047450032.1 → XP_047305988.1  cyclin-G-associated kinase isoform X41

  2. XM_047450022.1 → XP_047305978.1  cyclin-G-associated kinase isoform X32

  3. XM_047450019.1 → XP_047305975.1  cyclin-G-associated kinase isoform X28

  4. XM_017007992.2 → XP_016863481.1  cyclin-G-associated kinase isoform X17

    UniProtKB/TrEMBL
    B4DS37

  5. XM_047450028.1 → XP_047305984.1  cyclin-G-associated kinase isoform X37

  6. XM_047450024.1 → XP_047305980.1  cyclin-G-associated kinase isoform X34

  7. XM_047450025.1 → XP_047305981.1  cyclin-G-associated kinase isoform X35

  8. XM_047450031.1 → XP_047305987.1  cyclin-G-associated kinase isoform X40

  9. XM_047450015.1 → XP_047305971.1  cyclin-G-associated kinase isoform X24

  10. XM_047450004.1 → XP_047305960.1  cyclin-G-associated kinase isoform X12

  11. XM_047450021.1 → XP_047305977.1  cyclin-G-associated kinase isoform X31

  12. XM_047450029.1 → XP_047305985.1  cyclin-G-associated kinase isoform X38

  13. XM_011513430.2 → XP_011511732.1  cyclin-G-associated kinase isoform X8

    UniProtKB/TrEMBL
    B4DS37
    Conserved Domains (4) summary
    cd06257
    Location:1225 → 1269
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    smart00220
    Location:53 → 230
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam10409
    Location:491 → 629
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21453
    Location:46 → 241
    PKc_like; Protein Kinases, catalytic domain

  14. XM_011513434.3 → XP_011511736.1  cyclin-G-associated kinase isoform X26

    UniProtKB/TrEMBL
    Q59HA5
    Conserved Domains (4) summary
    cd06257
    Location:1168 → 1212
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    smart00220
    Location:1 → 173
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam10409
    Location:434 → 572
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21453
    Location:1 → 184
    PKc_like; Protein Kinases, catalytic domain

  15. XM_047450030.1 → XP_047305986.1  cyclin-G-associated kinase isoform X39

  16. XM_047450012.1 → XP_047305968.1  cyclin-G-associated kinase isoform X21

  17. XM_047450002.1 → XP_047305958.1  cyclin-G-associated kinase isoform X10

  18. XM_047450010.1 → XP_047305966.1  cyclin-G-associated kinase isoform X18

  19. XM_017007991.2 → XP_016863480.1  cyclin-G-associated kinase isoform X7

    UniProtKB/TrEMBL
    B4DS37

  20. XM_011513427.3 → XP_011511729.1  cyclin-G-associated kinase isoform X3

    UniProtKB/TrEMBL
    B4DS37
    Conserved Domains (4) summary
    cd06257
    Location:1274 → 1318
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    smart00220
    Location:41 → 279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam10409
    Location:540 → 678
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21453
    Location:39 → 290
    PKc_like; Protein Kinases, catalytic domain

  21. XM_047450018.1 → XP_047305974.1  cyclin-G-associated kinase isoform X27

  22. XM_047450026.1 → XP_047305982.1  cyclin-G-associated kinase isoform X36

  23. XM_047450007.1 → XP_047305963.1  cyclin-G-associated kinase isoform X15

  24. XM_047450014.1 → XP_047305970.1  cyclin-G-associated kinase isoform X23

  25. XM_047450023.1 → XP_047305979.1  cyclin-G-associated kinase isoform X33

  26. XM_047450005.1 → XP_047305961.1  cyclin-G-associated kinase isoform X13

  27. XM_011513428.3 → XP_011511730.1  cyclin-G-associated kinase isoform X4

    UniProtKB/TrEMBL
    B4DS37
    Conserved Domains (4) summary
    cd06257
    Location:1255 → 1299
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    smart00220
    Location:41 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14036
    Location:39 → 320
    STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
    pfam10409
    Location:570 → 708
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

  28. XM_047450006.1 → XP_047305962.1  cyclin-G-associated kinase isoform X14

  29. XM_047450013.1 → XP_047305969.1  cyclin-G-associated kinase isoform X22

  30. XM_005272268.3 → XP_005272325.1  cyclin-G-associated kinase isoform X5

    UniProtKB/TrEMBL
    Q59HA5
    Conserved Domains (4) summary
    cd06257
    Location:1249 → 1293
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    smart00220
    Location:41 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14036
    Location:39 → 320
    STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
    pfam10409
    Location:570 → 708
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

  31. XM_011513426.3 → XP_011511728.1  cyclin-G-associated kinase isoform X2

    UniProtKB/TrEMBL
    Q59HA5
    Conserved Domains (4) summary
    cd06257
    Location:1293 → 1337
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    smart00220
    Location:41 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14036
    Location:39 → 320
    STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
    pfam10409
    Location:570 → 708
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

  32. XM_011513431.3 → XP_011511733.1  cyclin-G-associated kinase isoform X9

    UniProtKB/TrEMBL
    B4DS37
    Conserved Domains (4) summary
    cd06257
    Location:1221 → 1265
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    smart00220
    Location:41 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14036
    Location:39 → 320
    STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
    pfam10409
    Location:570 → 708
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

  33. XM_005272270.3 → XP_005272327.1  cyclin-G-associated kinase isoform X20

    UniProtKB/TrEMBL
    B4DS37
    Conserved Domains (4) summary
    cd06257
    Location:1185 → 1229
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    smart00220
    Location:41 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14036
    Location:39 → 320
    STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
    pfam10409
    Location:570 → 708
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

  34. XM_011513425.3 → XP_011511727.1  cyclin-G-associated kinase isoform X1

    UniProtKB/TrEMBL
    B4DS37
    Conserved Domains (4) summary
    cd06257
    Location:1304 → 1348
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    smart00220
    Location:41 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14036
    Location:39 → 320
    STKc_GAK; Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase
    pfam10409
    Location:570 → 708
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein

  35. XM_017007993.2 → XP_016863482.1  cyclin-G-associated kinase isoform X26

    UniProtKB/TrEMBL
    Q59HA5
    Conserved Domains (4) summary
    cd06257
    Location:1168 → 1212
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    smart00220
    Location:1 → 173
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam10409
    Location:434 → 572
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21453
    Location:1 → 184
    PKc_like; Protein Kinases, catalytic domain

  36. XM_011513432.3 → XP_011511734.1  cyclin-G-associated kinase isoform X11

    UniProtKB/TrEMBL
    Q59HA5
    Conserved Domains (4) summary
    cd06257
    Location:1216 → 1260
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    smart00220
    Location:1 → 221
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam10409
    Location:482 → 620
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21453
    Location:1 → 232
    PKc_like; Protein Kinases, catalytic domain

  37. XM_047450020.1 → XP_047305976.1  cyclin-G-associated kinase isoform X29

  38. XM_047450003.1 → XP_047305959.1  cyclin-G-associated kinase isoform X11

  39. XM_047450016.1 → XP_047305972.1  cyclin-G-associated kinase isoform X25

  40. XM_011513429.3 → XP_011511731.1  cyclin-G-associated kinase isoform X6

    UniProtKB/TrEMBL
    Q59HA5
    Conserved Domains (4) summary
    cd06257
    Location:1242 → 1286
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
    smart00220
    Location:24 → 247
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam10409
    Location:508 → 646
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    cl21453
    Location:25 → 258
    PKc_like; Protein Kinases, catalytic domain

  41. XM_047450011.1 → XP_047305967.1  cyclin-G-associated kinase isoform X19

  42. XM_047450008.1 → XP_047305964.1  cyclin-G-associated kinase isoform X16

  43. XM_047450034.1 → XP_047305990.1  cyclin-G-associated kinase isoform X42

  44. XM_047450035.1 → XP_047305991.1  cyclin-G-associated kinase isoform X43

  45. XM_047450033.1 → XP_047305989.1  cyclin-G-associated kinase isoform X42

  46. XM_017007994.2 → XP_016863483.1  cyclin-G-associated kinase isoform X30

    UniProtKB/TrEMBL
    B4DS37

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    847030..930388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054349615.1 → XP_054205590.1  cyclin-G-associated kinase isoform X41

  2. XM_054349606.1 → XP_054205581.1  cyclin-G-associated kinase isoform X32

  3. XM_054349602.1 → XP_054205577.1  cyclin-G-associated kinase isoform X28

  4. XM_054349590.1 → XP_054205565.1  cyclin-G-associated kinase isoform X17

  5. XM_054349611.1 → XP_054205586.1  cyclin-G-associated kinase isoform X37

  6. XM_054349608.1 → XP_054205583.1  cyclin-G-associated kinase isoform X34

  7. XM_054349609.1 → XP_054205584.1  cyclin-G-associated kinase isoform X35

  8. XM_054349614.1 → XP_054205589.1  cyclin-G-associated kinase isoform X40

  9. XM_054349597.1 → XP_054205572.1  cyclin-G-associated kinase isoform X24

  10. XM_054349585.1 → XP_054205560.1  cyclin-G-associated kinase isoform X12

  11. XM_054349605.1 → XP_054205580.1  cyclin-G-associated kinase isoform X31

  12. XM_054349612.1 → XP_054205587.1  cyclin-G-associated kinase isoform X38

  13. XM_054349581.1 → XP_054205556.1  cyclin-G-associated kinase isoform X8

  14. XM_054349600.1 → XP_054205575.1  cyclin-G-associated kinase isoform X26

  15. XM_054349613.1 → XP_054205588.1  cyclin-G-associated kinase isoform X39

  16. XM_054349594.1 → XP_054205569.1  cyclin-G-associated kinase isoform X21

  17. XM_054349583.1 → XP_054205558.1  cyclin-G-associated kinase isoform X10

  18. XM_054349591.1 → XP_054205566.1  cyclin-G-associated kinase isoform X18

  19. XM_054349580.1 → XP_054205555.1  cyclin-G-associated kinase isoform X7

  20. XM_054349576.1 → XP_054205551.1  cyclin-G-associated kinase isoform X3

  21. XM_054349601.1 → XP_054205576.1  cyclin-G-associated kinase isoform X27

  22. XM_054349610.1 → XP_054205585.1  cyclin-G-associated kinase isoform X36

  23. XM_054349588.1 → XP_054205563.1  cyclin-G-associated kinase isoform X15

  24. XM_054349596.1 → XP_054205571.1  cyclin-G-associated kinase isoform X23

  25. XM_054349607.1 → XP_054205582.1  cyclin-G-associated kinase isoform X33

  26. XM_054349586.1 → XP_054205561.1  cyclin-G-associated kinase isoform X13

  27. XM_054349577.1 → XP_054205552.1  cyclin-G-associated kinase isoform X4

  28. XM_054349587.1 → XP_054205562.1  cyclin-G-associated kinase isoform X14

  29. XM_054349595.1 → XP_054205570.1  cyclin-G-associated kinase isoform X22

  30. XM_054349578.1 → XP_054205553.1  cyclin-G-associated kinase isoform X5

  31. XM_054349575.1 → XP_054205550.1  cyclin-G-associated kinase isoform X2

  32. XM_054349582.1 → XP_054205557.1  cyclin-G-associated kinase isoform X9

  33. XM_054349593.1 → XP_054205568.1  cyclin-G-associated kinase isoform X20

  34. XM_054349574.1 → XP_054205549.1  cyclin-G-associated kinase isoform X1

  35. XM_054349599.1 → XP_054205574.1  cyclin-G-associated kinase isoform X26

  36. XM_054349584.1 → XP_054205559.1  cyclin-G-associated kinase isoform X11

  37. XM_054349603.1 → XP_054205578.1  cyclin-G-associated kinase isoform X29

  38. XM_054349598.1 → XP_054205573.1  cyclin-G-associated kinase isoform X25

  39. XM_054349579.1 → XP_054205554.1  cyclin-G-associated kinase isoform X6

  40. XM_054349592.1 → XP_054205567.1  cyclin-G-associated kinase isoform X19

  41. XM_054349589.1 → XP_054205564.1  cyclin-G-associated kinase isoform X16

  42. XM_054349617.1 → XP_054205592.1  cyclin-G-associated kinase isoform X42

  43. XM_054349618.1 → XP_054205593.1  cyclin-G-associated kinase isoform X43

  44. XM_054349616.1 → XP_054205591.1  cyclin-G-associated kinase isoform X42

  45. XM_054349604.1 → XP_054205579.1  cyclin-G-associated kinase isoform X30

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001286833.1: Suppressed sequence

    Description
    NM_001286833.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14976.2 GenPept UniProtKB/Swiss-Prot:O14976

Gene LinkOut

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