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Sdsl serine dehydratase-like [ Mus musculus (house mouse) ]

Gene ID: 257635, updated on 11-Apr-2024

Summary

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Official Symbol
Sdslprovided by MGI
Official Full Name
serine dehydratase-likeprovided by MGI
Primary source
MGI:MGI:2182607
See related
Ensembl:ENSMUSG00000029596 AllianceGenome:MGI:2182607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TDH; SDH1; SDS-RS1; 4432411H13Rik
Summary
Predicted to enable L-threonine ammonia-lyase activity and identical protein binding activity. Predicted to be involved in isoleucine biosynthetic process and threonine catabolic process. Located in mitochondrion. Is expressed in several structures, including genitourinary system; immune system; liver; musculature; and notochord. Orthologous to human SDSL (serine dehydratase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 41.3), duodenum adult (RPKM 15.9) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 60.62 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120596258..120610890, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120458193..120472825, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene LIM homeobox 5, antisense 1 Neighboring gene LIM homeobox protein 5 Neighboring gene serine dehydratase Neighboring gene phospholipase B domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E2173 Neighboring gene solute carrier family 8 (sodium/lithium/calcium exchanger), member B1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mice have a transcribed L-threonine aldolase/GLY1 gene, but the human GLY1 gene is a non-processed pseudogene. Edgar AJ. BMC Genomics, 2005 Mar 9. PMID 15757516, Free PMC Article
  2. Positional cloning of the murine flavivirus resistance gene. Perelygin AA, et al. Proc Natl Acad Sci U S A, 2002 Jul 9. PMID 12080145, Free PMC Article
  3. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables threonine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in L-serine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoleucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in threonine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
serine dehydratase-like
Names
L-serine deaminase
L-serine dehydratase/L-threonine deaminase
L-threonine dehydratase
SDH
serine dehydratase related sequence 1
NP_001371183.1
NP_598663.2
XP_011246504.2
XP_036021034.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384254.1 → NP_001371183.1  serine dehydratase-like

    Status: VALIDATED

    Source sequence(s)
    AC129553
    UniProtKB/Swiss-Prot
    Q8R238, Q8VI05
    Related
    ENSMUSP00000031594.7, ENSMUST00000031594.13
    Conserved Domains (1) summary
    cd06448
    Location:17 → 326
    L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

  2. NM_133902.3 → NP_598663.2  serine dehydratase-like

    See identical proteins and their annotated locations for NP_598663.2

    Status: VALIDATED

    Source sequence(s)
    AC129553
    Consensus CDS
    CCDS19618.1
    UniProtKB/Swiss-Prot
    Q8R238, Q8VI05
    Related
    ENSMUSP00000058198.8, ENSMUST00000052258.14
    Conserved Domains (1) summary
    cd06448
    Location:17 → 326
    L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    120596258..120610890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248202.2 → XP_011246504.2  serine dehydratase-like isoform X1

    UniProtKB/Swiss-Prot
    Q8R238, Q8VI05
    Conserved Domains (1) summary
    cd06448
    Location:17 → 326
    L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

  2. XM_036165141.1 → XP_036021034.1  serine dehydratase-like isoform X2

    Conserved Domains (1) summary
    cl00342
    Location:20 → 274
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R238.1 GenPept UniProtKB/Swiss-Prot:Q8R238

Gene LinkOut

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