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Acsf3 acyl-CoA synthetase family member 3 [ Mus musculus (house mouse) ]

Gene ID: 257633, updated on 21-Apr-2024

Summary

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Official Symbol
Acsf3provided by MGI
Official Full Name
acyl-CoA synthetase family member 3provided by MGI
Primary source
MGI:MGI:2182591
See related
Ensembl:ENSMUSG00000015016 AllianceGenome:MGI:2182591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable malonyl-CoA synthetase activity and very long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty acid biosynthetic process and malonate catabolic process. Predicted to act upstream of or within lipid metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined malonic and methylmalonic acidemia. Orthologous to human ACSF3 (acyl-CoA synthetase family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 25.7), adrenal adult (RPKM 17.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 71.97 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123502209..123544626)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122775470..122817887)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530010L16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:125299226-125299409 Neighboring gene predicted gene, 39271 Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene cadherin 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Aberrant methylmalonylation underlies methylmalonic acidemia and is attenuated by an engineered sirtuin. Head PE, et al. Sci Transl Med, 2022 May 25. PMID 35613279, Free PMC Article
  2. The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency. Bowman CE, et al. Cell Chem Biol, 2017 Jun 22. PMID 28479296, Free PMC Article
  3. Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation. Menendez-Montes I, et al. Dev Cell, 2016 Dec 19. PMID 27997827
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. an essential role for ACSF3 in dictating the metabolic fate of mitochondrial malonate and malonyl-CoA in mammalian metabolism
    Title: The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC37904

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acid-thiol ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables malonyl-CoA synthetase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables very long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables very long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in malonate catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
malonate--CoA ligase ACSF3, mitochondrial
Names
acyl-CoA synthetase family member 3, mitochondrial
NP_659181.2
XP_006531093.1
XP_006531095.1
XP_030099428.1
XP_030099430.1
XP_036009945.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144932.4 → NP_659181.2  malonate--CoA ligase ACSF3, mitochondrial precursor

    See identical proteins and their annotated locations for NP_659181.2

    Status: VALIDATED

    Source sequence(s)
    AA104822, AK141579, AK144352, BI135241, BQ177632
    Consensus CDS
    CCDS40505.1
    UniProtKB/Swiss-Prot
    Q3URE1, Q78IW2, Q8VC75
    UniProtKB/TrEMBL
    A0A1D5RMC8
    Related
    ENSMUSP00000015160.6, ENSMUST00000015160.6
    Conserved Domains (1) summary
    cd05941
    Location:55 → 569
    MCS; Malonyl-CoA synthetase (MCS)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123502209..123544626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243568.1 → XP_030099428.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q3URE1, Q78IW2, Q8VC75
    UniProtKB/TrEMBL
    A0A1D5RMC8
    Conserved Domains (1) summary
    cd05941
    Location:55 → 569
    MCS; Malonyl-CoA synthetase (MCS)

  2. XM_006531030.3 → XP_006531093.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006531093.1

    UniProtKB/Swiss-Prot
    Q3URE1, Q78IW2, Q8VC75
    UniProtKB/TrEMBL
    A0A1D5RMC8
    Related
    ENSMUSP00000148762.2, ENSMUST00000212790.2
    Conserved Domains (1) summary
    cd05941
    Location:55 → 569
    MCS; Malonyl-CoA synthetase (MCS)

  3. XM_006531032.4 → XP_006531095.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006531095.1

    UniProtKB/Swiss-Prot
    Q3URE1, Q78IW2, Q8VC75
    UniProtKB/TrEMBL
    A0A1D5RMC8
    Related
    ENSMUSP00000148725.2, ENSMUST00000212781.2
    Conserved Domains (1) summary
    cd05941
    Location:55 → 569
    MCS; Malonyl-CoA synthetase (MCS)

  4. XM_036154052.1 → XP_036009945.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q3URE1, Q78IW2, Q8VC75
    UniProtKB/TrEMBL
    A0A1D5RMC8
    Conserved Domains (1) summary
    cd05941
    Location:55 → 569
    MCS; Malonyl-CoA synthetase (MCS)

  5. XM_030243570.1 → XP_030099430.1  malonate--CoA ligase ACSF3, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q3URE1, Q78IW2, Q8VC75
    UniProtKB/TrEMBL
    A0A1D5RMC8
    Conserved Domains (1) summary
    cd05941
    Location:55 → 569
    MCS; Malonyl-CoA synthetase (MCS)

RNA

  1. XR_003947284.1 RNA Sequence

  2. XR_003947283.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3URE1.2 GenPept UniProtKB/Swiss-Prot:Q3URE1

Gene LinkOut

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