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EML3 EMAP like 3 [ Homo sapiens (human) ]

Gene ID: 256364, updated on 11-Apr-2024

Summary

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Official Symbol
EML3provided by HGNC
Official Full Name
EMAP like 3provided by HGNC
Primary source
HGNC:HGNC:26666
See related
Ensembl:ENSG00000149499 MIM:618118; AllianceGenome:HGNC:26666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELP95; EMAP3; EMAP95
Summary
Predicted to enable microtubule binding activity. Involved in mitotic metaphase plate congression and regulation of mitotic spindle assembly. Located in several cellular components, including midbody; mitotic spindle microtubule; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 13.3), fat (RPKM 13.0) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11q12.3
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62602218..62612775, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62591666..62602223, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62369690..62380247, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62342449-62343410 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62358805-62359500 Neighboring gene metastasis associated 1 family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4828 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62368208-62368918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3419 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62370341-62371050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4831 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62378772-62379330 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62379331-62379890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62384118-62384618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62384619-62385119 Neighboring gene retinal outer segment membrane protein 1 Neighboring gene beta-1,3-glucuronyltransferase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62388711-62389304

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Eml5, a novel WD40 domain protein expressed in rat brain. O'Connor V, et al. Gene, 2004 Jul 7. PMID 15225882
  2. Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain. Richards MW, et al. Biochem J, 2015 May 1. PMID 25740311
  3. The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules. Luo J, et al. J Biol Chem, 2019 Apr 5. PMID 30723163, Free PMC Article
  4. EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase. Tegha-Dunghu J, et al. J Cell Sci, 2008 May 15. PMID 18445686
  5. Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy. Tian Y, et al. Proc Natl Acad Sci U S A, 2013 Oct 15. PMID 24067654, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results indicate that EML3 regulates mitotic spindle assembly and the kinetochore-MT connection by regulating MT-based MT nucleation and recruiting Augmin/gamma-TuRC to MTs.
    Title: The microtubule-associated protein EML3 regulates mitotic spindle assembly by recruiting the Augmin complex to spindle microtubules.
  2. Functional analysis of EML3 demonstrates an important role for EML3 in correct metaphase chromosome alignment.
    Title: EML3 is a nuclear microtubule-binding protein required for the correct alignment of chromosomes in metaphase.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with echinoderm microtubule associated protein like 3 (EML3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35827, MGC111422

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
echinoderm microtubule-associated protein-like 3
Names
EMAP-3
echinoderm microtubule associated protein like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300793.2 → NP_001287722.1  echinoderm microtubule-associated protein-like 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK093146, AP001458, BC050467, CN386216
    UniProtKB/TrEMBL
    B4DL97
    Related
    ENSP00000378256.4, ENST00000394776.8
    Conserved Domains (5) summary
    smart00320
    Location:300 → 344
    WD40; WD40 repeats
    COG2319
    Location:348 → 756
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:216 → 285
    HELP; HELP motif
    sd00039
    Location:518 → 556
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:399 → 755
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001300794.2 → NP_001287723.1  echinoderm microtubule-associated protein-like 3 isoform 2

    See identical proteins and their annotated locations for NP_001287723.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AK296901, AP001458, BC050467, CN386216, CN386217
    Consensus CDS
    CCDS76415.1
    UniProtKB/TrEMBL
    B4DL97
    Related
    ENSP00000434513.1, ENST00000529309.5
    Conserved Domains (5) summary
    smart00320
    Location:299 → 343
    WD40; WD40 repeats
    COG2319
    Location:347 → 755
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:215 → 284
    HELP; HELP motif
    sd00039
    Location:517 → 555
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:398 → 754
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001411016.1 → NP_001397945.1  echinoderm microtubule-associated protein-like 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AP001458
    Consensus CDS
    CCDS91491.1
    UniProtKB/TrEMBL
    B7WPE2
    Related
    ENSP00000278845.4, ENST00000278845.8

  4. NM_153265.3 → NP_694997.2  echinoderm microtubule-associated protein-like 3 isoform 3

    See identical proteins and their annotated locations for NP_694997.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 5' end of an exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) lacks a single alternate aa and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AP001458, BC050467, BC108280, CN386216, CN386217
    Consensus CDS
    CCDS8023.2
    UniProtKB/Swiss-Prot
    Q32P44, Q6ZQW7, Q8NA55
    UniProtKB/TrEMBL
    B4DL97
    Related
    ENSP00000378254.2, ENST00000394773.7
    Conserved Domains (3) summary
    sd00039
    Location:517 → 555
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:215 → 284
    HELP; HELP motif
    cl29593
    Location:551 → 868
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    62602218..62612775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426716.1 → XP_047282672.1  echinoderm microtubule-associated protein-like 3 isoform X7

  2. XM_047426717.1 → XP_047282673.1  echinoderm microtubule-associated protein-like 3 isoform X8

  3. XM_011544896.4 → XP_011543198.1  echinoderm microtubule-associated protein-like 3 isoform X2

    UniProtKB/TrEMBL
    H0Y3M3
    Conserved Domains (5) summary
    smart00320
    Location:349 → 393
    WD40; WD40 repeats
    COG2319
    Location:397 → 805
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:265 → 334
    HELP; HELP motif
    sd00039
    Location:567 → 605
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:448 → 804
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_006718491.5 → XP_006718554.1  echinoderm microtubule-associated protein-like 3 isoform X4

    UniProtKB/TrEMBL
    H0Y3M3
    Conserved Domains (4) summary
    COG2319
    Location:563 → 920
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:265 → 334
    HELP; HELP motif
    sd00039
    Location:567 → 605
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:601 → 918
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_011544897.4 → XP_011543199.1  echinoderm microtubule-associated protein-like 3 isoform X5

    UniProtKB/TrEMBL
    H0Y3M3
    Conserved Domains (4) summary
    COG2319
    Location:352 → 754
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:266 → 335
    HELP; HELP motif
    sd00039
    Location:516 → 554
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:350 → 753
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_006718489.5 → XP_006718552.1  echinoderm microtubule-associated protein-like 3 isoform X1

    UniProtKB/TrEMBL
    H0Y3M3
    Conserved Domains (5) summary
    smart00320
    Location:350 → 394
    WD40; WD40 repeats
    COG2319
    Location:398 → 806
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:266 → 335
    HELP; HELP motif
    sd00039
    Location:568 → 606
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:449 → 805
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_006718490.5 → XP_006718553.1  echinoderm microtubule-associated protein-like 3 isoform X3

    UniProtKB/TrEMBL
    H0Y3M3
    Conserved Domains (4) summary
    COG2319
    Location:564 → 921
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:266 → 335
    HELP; HELP motif
    sd00039
    Location:568 → 606
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:602 → 919
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_047426715.1 → XP_047282671.1  echinoderm microtubule-associated protein-like 3 isoform X6

    Related
    ENSP00000435064.1, ENST00000494176.6

  9. XM_017017481.3 → XP_016872970.1  echinoderm microtubule-associated protein-like 3 isoform X9

    UniProtKB/TrEMBL
    G3V1D0

  10. XM_017017482.2 → XP_016872971.1  echinoderm microtubule-associated protein-like 3 isoform X10

    UniProtKB/TrEMBL
    A0A024R532, G3V195
    Conserved Domains (4) summary
    COG2319
    Location:397 → 754
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:99 → 168
    HELP; HELP motif
    sd00039
    Location:401 → 439
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:435 → 752
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  11. XM_047426718.1 → XP_047282674.1  echinoderm microtubule-associated protein-like 3 isoform X11

    Related
    ENSP00000433417.1, ENST00000531557.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    62591666..62602223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368327.1 → XP_054224302.1  echinoderm microtubule-associated protein-like 3 isoform X7

  2. XM_054368328.1 → XP_054224303.1  echinoderm microtubule-associated protein-like 3 isoform X8

  3. XM_054368323.1 → XP_054224298.1  echinoderm microtubule-associated protein-like 3 isoform X3

  4. XM_054368325.1 → XP_054224300.1  echinoderm microtubule-associated protein-like 3 isoform X5

  5. XM_054368322.1 → XP_054224297.1  echinoderm microtubule-associated protein-like 3 isoform X2

  6. XM_054368321.1 → XP_054224296.1  echinoderm microtubule-associated protein-like 3 isoform X1

  7. XM_054368324.1 → XP_054224299.1  echinoderm microtubule-associated protein-like 3 isoform X4

  8. XM_054368326.1 → XP_054224301.1  echinoderm microtubule-associated protein-like 3 isoform X6

  9. XM_054368329.1 → XP_054224304.1  echinoderm microtubule-associated protein-like 3 isoform X9

  10. XM_054368330.1 → XP_054224305.1  echinoderm microtubule-associated protein-like 3 isoform X10

  11. XM_054368331.1 → XP_054224306.1  echinoderm microtubule-associated protein-like 3 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32P44.1 GenPept UniProtKB/Swiss-Prot:Q32P44

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