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LMNTD2 lamin tail domain containing 2 [ Homo sapiens (human) ]

Gene ID: 256329, updated on 5-Mar-2024

Summary

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Official Symbol
LMNTD2provided by HGNC
Official Full Name
lamin tail domain containing 2provided by HGNC
Primary source
HGNC:HGNC:28561
See related
Ensembl:ENSG00000185522 AllianceGenome:HGNC:28561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C11orf35
Summary
Predicted to be a structural constituent of chromatin. Predicted to be involved in regulation of chromatin assembly. Predicted to act upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be active in lamin filament. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 5.4), lung (RPKM 3.1) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11p15.5
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (554850..560738, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (601835..607742, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (554850..560738, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribonuclease/angiogenin inhibitor 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21531 Neighboring gene leucine rich repeat containing 56 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:528505-529042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:533792-534649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:534650-535506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:535528-536235 Neighboring gene HRas proto-oncogene, GTPase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:540668-541490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:543860-544362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:544865-545366 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr11:548147-548965 and GRCh37_chr11:548966-549783 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:556675-557511 Neighboring gene LMNTD2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:561773-562348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:565694-566248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:566249-566803 Neighboring gene Ras association domain family member 7 Neighboring gene MIR210 host gene Neighboring gene microRNA 210

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC35138

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lamin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lamin tail domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173573.3 → NP_775844.2  lamin tail domain-containing protein 2

    See identical proteins and their annotated locations for NP_775844.2

    Status: VALIDATED

    Source sequence(s)
    AI539379, AP006284, BC039077, BX384084, BX384085
    Consensus CDS
    CCDS7701.1
    UniProtKB/Swiss-Prot
    Q8IXW0
    Related
    ENSP00000331167.3, ENST00000329451.8
    Conserved Domains (3) summary
    pfam00932
    Location:372 → 464
    LTD; Lamin Tail Domain
    cd16269
    Location:138 → 148
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:109 → 160
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    554850..560738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426713.1 → XP_047282669.1  lamin tail domain-containing protein 2 isoform X3

  2. XM_047426712.1 → XP_047282668.1  lamin tail domain-containing protein 2 isoform X2

  3. XM_011519967.3 → XP_011518269.2  lamin tail domain-containing protein 2 isoform X4

  4. XM_011519965.3 → XP_011518267.2  lamin tail domain-containing protein 2 isoform X1

  5. XM_017017479.3 → XP_016872968.1  lamin tail domain-containing protein 2 isoform X5

  6. XM_047426714.1 → XP_047282670.1  lamin tail domain-containing protein 2 isoform X6

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187586.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    84490..90393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328896.1 → XP_054184871.1  lamin tail domain-containing protein 2 isoform X3

  2. XM_054328894.1 → XP_054184869.1  lamin tail domain-containing protein 2 isoform X11

  3. XM_054328893.1 → XP_054184868.1  lamin tail domain-containing protein 2 isoform X10

  4. XM_054328895.1 → XP_054184870.1  lamin tail domain-containing protein 2 isoform X2

  5. XM_054328891.1 → XP_054184866.1  lamin tail domain-containing protein 2 isoform X1

  6. XM_054328890.1 → XP_054184865.1  lamin tail domain-containing protein 2 isoform X8

  7. XM_054328892.1 → XP_054184867.1  lamin tail domain-containing protein 2 isoform X9

  8. XM_054328889.1 → XP_054184864.1  lamin tail domain-containing protein 2 isoform X7

  9. XM_054328897.1 → XP_054184872.1  lamin tail domain-containing protein 2 isoform X12

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    601835..607742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368319.1 → XP_054224294.1  lamin tail domain-containing protein 2 isoform X3

  2. XM_054368317.1 → XP_054224292.1  lamin tail domain-containing protein 2 isoform X17

  3. XM_054368316.1 → XP_054224291.1  lamin tail domain-containing protein 2 isoform X16

  4. XM_054368318.1 → XP_054224293.1  lamin tail domain-containing protein 2 isoform X2

  5. XM_054368314.1 → XP_054224289.1  lamin tail domain-containing protein 2 isoform X1

  6. XM_054368313.1 → XP_054224288.1  lamin tail domain-containing protein 2 isoform X14

  7. XM_054368315.1 → XP_054224290.1  lamin tail domain-containing protein 2 isoform X15

  8. XM_054368312.1 → XP_054224287.1  lamin tail domain-containing protein 2 isoform X13

  9. XM_054368320.1 → XP_054224295.1  lamin tail domain-containing protein 2 isoform X18

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IXW0.2 GenPept UniProtKB/Swiss-Prot:Q8IXW0

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