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STEAP1B STEAP family member 1B [ Homo sapiens (human) ]

Gene ID: 256227, updated on 3-Apr-2024

Summary

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Official Symbol
STEAP1Bprovided by HGNC
Official Full Name
STEAP family member 1Bprovided by HGNC
Primary source
HGNC:HGNC:41907
See related
Ensembl:ENSG00000105889 AllianceGenome:HGNC:41907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. Predicted to be active in endosome and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in prostate (RPKM 3.5), appendix (RPKM 1.8) and 15 other tissues See more
Orthologs
all
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Genomic context

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Location:
7p15.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (22419444..22500188, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (22555533..22636076, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (22459063..22539807, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 11 Neighboring gene NANOG hESC enhancer GRCh37_chr7:21981192-21981812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:21985471-21986181 Neighboring gene cell division cycle associated 7 like Neighboring gene VISTA enhancer hs807 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:22097966 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:22117733 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:22118756 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:22119917 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:22121421 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:22123422 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:22141595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17999 Neighboring gene NANOG hESC enhancer GRCh37_chr7:22218362-22218864 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:22224198-22225096 Neighboring gene Rap guanine nucleotide exchange factor 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:22281835-22282335 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:22369304-22369804 Neighboring gene RNA, 5S ribosomal pseudogene 227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18002 Neighboring gene HNF4 motif-containing MPRA enhancer 142 Neighboring gene GATA motif-containing MPRA enhancer 55/56 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:22517166-22517666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:22517667-22518167 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:22602981-22603482 Neighboring gene STEAP1B antisense RNA 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of STEAP1 and STEAP1B in prostate cell lines, and the putative regulation of STEAP1 by post-transcriptional and post-translational mechanisms. Gomes IM, et al. Genes Cancer, 2014 Mar. PMID 25053991, Free PMC Article
  2. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. Murea M, et al. Am J Nephrol, 2011. PMID 21546767, Free PMC Article
  3. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Stukalov A, et al. Nature, 2021 Jun. PMID 33845483
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article
  5. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. Haenig C, et al. Cell Rep, 2020 Aug 18. PMID 32814053

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC87042

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
STEAP family member 1B
Names
STEAP family protein MGC87042

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164460.2 → NP_001157932.1  STEAP family member 1B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC002480, AC099759, AK308991
    Consensus CDS
    CCDS56469.1
    UniProtKB/Swiss-Prot
    Q6NZ63
    Related
    ENSP00000384370.4, ENST00000404369.8
    Conserved Domains (1) summary
    pfam01794
    Location:121 → 241
    Ferric_reduct; Ferric reductase like transmembrane component

  2. NM_001382447.1 → NP_001369376.1  STEAP family member 1B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC002480, AC005061, AC099759
    Consensus CDS
    CCDS94065.1
    UniProtKB/TrEMBL
    A0A7I2V339, C9JE84
    Related
    ENSP00000503251.1, ENST00000678116.1
    Conserved Domains (1) summary
    pfam01794
    Location:121 → 241
    Ferric_reduct; Ferric reductase like transmembrane component

  3. NM_207342.3 → NP_997225.1  STEAP family member 1B isoform 2

    See identical proteins and their annotated locations for NP_997225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and an alternate 3' exon with a distinct 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) lacks an internal segment near the N-terminus and has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC002480, AC005061, AC099759
    Consensus CDS
    CCDS55094.1
    UniProtKB/Swiss-Prot
    B5MCI2, Q6NZ63
    UniProtKB/TrEMBL
    C9JE84
    Related
    ENSP00000385239.2, ENST00000406890.6
    Conserved Domains (1) summary
    pfam01794
    Location:102 → 222
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    22419444..22500188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420109.1 → XP_047276065.1  STEAP family member 1B isoform X5

  2. XM_047420107.1 → XP_047276063.1  STEAP family member 1B isoform X3

  3. XM_047420103.1 → XP_047276059.1  STEAP family member 1B isoform X1

  4. XM_047420104.1 → XP_047276060.1  STEAP family member 1B isoform X1

  5. XM_047420108.1 → XP_047276064.1  STEAP family member 1B isoform X4

    Related
    ENSP00000416608.1, ENST00000424363.5

  6. XM_047420111.1 → XP_047276067.1  STEAP family member 1B isoform X7

  7. XM_047420110.1 → XP_047276066.1  STEAP family member 1B isoform X6

  8. XM_047420106.1 → XP_047276062.1  STEAP family member 1B isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    22555533..22636076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357753.1 → XP_054213728.1  STEAP family member 1B isoform X5

  2. XM_054357751.1 → XP_054213726.1  STEAP family member 1B isoform X3

  3. XM_054357748.1 → XP_054213723.1  STEAP family member 1B isoform X1

  4. XM_054357749.1 → XP_054213724.1  STEAP family member 1B isoform X1

  5. XM_054357752.1 → XP_054213727.1  STEAP family member 1B isoform X4

  6. XM_054357754.1 → XP_054213729.1  STEAP family member 1B isoform X6

  7. XM_054357755.1 → XP_054213730.1  STEAP family member 1B isoform X7

  8. XM_054357750.1 → XP_054213725.1  STEAP family member 1B isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NZ63.1 GenPept UniProtKB/Swiss-Prot:Q6NZ63

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