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Asns asparagine synthetase (glutamine-hydrolyzing) [ Rattus norvegicus (Norway rat) ]

Gene ID: 25612, updated on 5-Mar-2024

Summary

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Official Symbol
Asnsprovided by RGD
Official Full Name
asparagine synthetase (glutamine-hydrolyzing)provided by RGD
Primary source
RGD:2162
See related
Ensembl:ENSRNOG00000007546 AllianceGenome:RGD:2162
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables asparagine synthase (glutamine-hydrolyzing) activity and identical protein binding activity. Involved in several processes, including asparagine biosynthetic process; cellular response to glucose starvation; and response to follicle-stimulating hormone. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 212.2), Testes (RPKM 153.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (36752061..36769970, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (35784995..35803474, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (33742876..33761106, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene tachykinin, precursor 1 Neighboring gene Set nuclear proto-oncogene, pseudogene 6 Neighboring gene uncharacterized LOC134486668 Neighboring gene tRNA (guanine-N(7)-)-methyltransferase-like Neighboring gene RNA polymerase I and III subunit D, pseudogene 1 Neighboring gene core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcriptional responses in thyroid tissues from rats treated with a tumorigenic and a non-tumorigenic triazole conazole fungicide. Hester SD, et al. Toxicol Appl Pharmacol, 2008 Mar 15. PMID 18164361
  2. Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells. Hutson RG, et al. Am J Physiol, 1997 May. PMID 9176161
  3. Induction of asparagine synthetase by follicle-stimulating hormone in primary cultures of rat Sertoli cells. Hongo S, et al. Arch Biochem Biophys, 1994 Sep. PMID 7915898
  4. Cloning of rat asparagine synthetase and specificity of the amino acid-dependent control of its mRNA content. Hutson RG, et al. Biochem J, 1994 Dec 15. PMID 7818476, Free PMC Article
  5. Some molecular properties of asparagine synthetase from rat liver. Hongo S, et al. Biochim Biophys Acta, 1983 Feb 15. PMID 6132621

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93148

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables asparagine synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asparagine synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables asparagine synthase (glutamine-hydrolyzing) activity ISO
Inferred from Sequence Orthology
more info
  
enables asparagine synthase (glutamine-hydrolyzing) activity TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-asparagine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid metabolic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in asparagine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in asparagine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within asparagine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucose starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hormone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in liver development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in response to aldosterone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to amino acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to follicle-stimulating hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to light stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
asparagine synthetase [glutamine-hydrolyzing]
Names
glutamine-dependent asparagine synthetase
NP_037211.2
XP_006236151.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013079.2 → NP_037211.2  asparagine synthetase [glutamine-hydrolyzing]

    See identical proteins and their annotated locations for NP_037211.2

    Status: PROVISIONAL

    Source sequence(s)
    BC081719
    UniProtKB/Swiss-Prot
    P49088, Q66HR8
    UniProtKB/TrEMBL
    A6IDW2, A6IDW3
    Conserved Domains (1) summary
    PRK09431
    Location:1 → 560
    asnB; asparagine synthetase B; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    36752061..36769970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236089.5 → XP_006236151.1  asparagine synthetase [glutamine-hydrolyzing] isoform X1

    See identical proteins and their annotated locations for XP_006236151.1

    UniProtKB/Swiss-Prot
    P49088, Q66HR8
    UniProtKB/TrEMBL
    A6IDW2, A6IDW3
    Related
    ENSRNOP00000010079.3
    Conserved Domains (1) summary
    PRK09431
    Location:1 → 560
    asnB; asparagine synthetase B; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49088.3 GenPept UniProtKB/Swiss-Prot:P49088

Gene LinkOut

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