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EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B [ Homo sapiens (human) ]

Gene ID: 255308, updated on 7-Apr-2024

Summary

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Official Symbol
EIF2S3Bprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 2 subunit gamma Bprovided by HGNC
Primary source
HGNC:HGNC:43863
See related
Ensembl:ENSG00000180574 AllianceGenome:HGNC:43863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
eIF2gA; EIF2S3L; eIF-2gA
Summary
Predicted to enable translation initiation factor activity. Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex and positive regulation of translational fidelity. Predicted to be part of eukaryotic translation initiation factor 2 complex. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See EIF2S3B in Genome Data Viewer
Location:
12p13.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10505890..10523135)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10377306..10394552)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10658489..10675734)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene killer cell lectin like receptor C2 Neighboring gene killer cell lectin like receptor C1 Neighboring gene uncharacterized LOC105369657 Neighboring gene uncharacterized LOC105369658 Neighboring gene SLC25A39 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Emergence of young human genes after a burst of retroposition in primates. Marques AC, et al. PLoS Biol, 2005 Nov. PMID 16201836, Free PMC Article
  2. The finished DNA sequence of human chromosome 12. Scherer SE, et al. Nature, 2006 Mar 16. PMID 16541075
  3. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. Wang B, et al. EBioMedicine, 2019 Mar. PMID 30745168, Free PMC Article
  4. Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling. Tan P, et al. Mol Cell, 2017 Oct 19. PMID 29053956
  5. UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination. Ma M, et al. Oncogene, 2022 Nov. PMID 36273042

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 2 subunit 3B
Names
eIF-2-gamma2
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
putative eukaryotic translation initiation factor 2 subunit 3-like protein
NP_001344660.1
NP_001344663.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357731.1 → NP_001344660.1  eukaryotic translation initiation factor 2 subunit 3B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068775, BC087847, DB461648
    Consensus CDS
    CCDS86282.1
    Related
    ENSP00000323063.3, ENST00000322446.3
    Conserved Domains (1) summary
    PTZ00327
    Location:13 → 438
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

  2. NM_001357734.3 → NP_001344663.1  eukaryotic translation initiation factor 2 subunit 3B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC068775
    Consensus CDS
    CCDS91654.1
    UniProtKB/Swiss-Prot
    F8W810, Q2VIR3, Q5I0X0, Q6KF84
    Related
    ENSP00000445077.1, ENST00000538173.2
    Conserved Domains (1) summary
    PTZ00327
    Location:13 → 466
    PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    10505890..10523135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    10377306..10394552
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_003215.3: Suppressed sequence

    Description
    NG_003215.3: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2VIR3.2 GenPept UniProtKB/Swiss-Prot:Q2VIR3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials