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TMCO4 transmembrane and coiled-coil domains 4 [ Homo sapiens (human) ]

Gene ID: 255104, updated on 3-Apr-2024

Summary

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Official Symbol
TMCO4provided by HGNC
Official Full Name
transmembrane and coiled-coil domains 4provided by HGNC
Primary source
HGNC:HGNC:27393
See related
Ensembl:ENSG00000162542 AllianceGenome:HGNC:27393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum (RPKM 7.2), prostate (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

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See TMCO4 in Genome Data Viewer
Location:
1p36.13
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (19682240..19799916, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (19505616..19623756, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20008733..20126409, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MICOS10-NBL1 readthrough Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19969817-19970652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19976919-19977536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 359 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19991190-19992162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19992163-19993133 Neighboring gene NBL1, DAN family BMP antagonist Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:20015541-20016055 Neighboring gene 5-hydroxytryptamine receptor 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20066909-20067410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20067411-20067910 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:20076458-20077657 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:20091493-20092692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:20106613-20107114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 306 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 307 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:20126577-20127077 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:20143237-20143768 Neighboring gene RNF186 antisense RNA 1 Neighboring gene ring finger protein 186 Neighboring gene uncharacterized LOC105376823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 308 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 362 Neighboring gene OTU deubiquitinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins. Hémono M, et al. BMC Biol, 2022 Jan 10. PMID 35012549, Free PMC Article
  2. A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins. May DG, et al. Viruses, 2022 Mar 15. PMID 35337019, Free PMC Article
  3. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
  4. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Fei T, et al. Proc Natl Acad Sci U S A, 2017 Jun 27. PMID 28611215, Free PMC Article
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686C23231

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane and coiled-coil domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349112.3 → NP_001336041.1  transmembrane and coiled-coil domain-containing protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL031727, AL031730, AL391883
    Consensus CDS
    CCDS198.1
    UniProtKB/Swiss-Prot
    Q5TGY1, Q5TGY2, Q6MZN5, Q7Z6K6, Q9UQP4, Q9Y3K1
    UniProtKB/TrEMBL
    A0A075B6H3
    Conserved Domains (1) summary
    cl21494
    Location:185 → 521
    Abhydrolase; alpha/beta hydrolases

  2. NM_001349113.3 → NP_001336042.1  transmembrane and coiled-coil domain-containing protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL031727, AL031730, AL391883
    Consensus CDS
    CCDS198.1
    UniProtKB/Swiss-Prot
    Q5TGY1, Q5TGY2, Q6MZN5, Q7Z6K6, Q9UQP4, Q9Y3K1
    UniProtKB/TrEMBL
    A0A075B6H3
    Related
    ENSP00000364269.1, ENST00000375127.5
    Conserved Domains (1) summary
    cl21494
    Location:185 → 521
    Abhydrolase; alpha/beta hydrolases

  3. NM_001349114.3 → NP_001336043.1  transmembrane and coiled-coil domain-containing protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL031727, AL031730, AL391883
    Consensus CDS
    CCDS198.1
    UniProtKB/Swiss-Prot
    Q5TGY1, Q5TGY2, Q6MZN5, Q7Z6K6, Q9UQP4, Q9Y3K1
    UniProtKB/TrEMBL
    A0A075B6H3
    Conserved Domains (1) summary
    cl21494
    Location:185 → 521
    Abhydrolase; alpha/beta hydrolases

  4. NM_001349115.1 → NP_001336044.1  transmembrane and coiled-coil domain-containing protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks multiple 3' coding exons and contains an alternate 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK309310, AL031730, AL391883, BX108228
    Conserved Domains (1) summary
    cl21494
    Location:185 → 294
    Abhydrolase; alpha/beta hydrolases

  5. NM_181719.7 → NP_859070.3  transmembrane and coiled-coil domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_859070.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK127543, BM974434, BX640987
    Consensus CDS
    CCDS198.1
    UniProtKB/Swiss-Prot
    Q5TGY1, Q5TGY2, Q6MZN5, Q7Z6K6, Q9UQP4, Q9Y3K1
    UniProtKB/TrEMBL
    A0A075B6H3
    Related
    ENSP00000294543.6, ENST00000294543.11
    Conserved Domains (1) summary
    cl21494
    Location:185 → 521
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    19682240..19799916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541185.4 → XP_011539487.1  transmembrane and coiled-coil domain-containing protein 4 isoform X5

    See identical proteins and their annotated locations for XP_011539487.1

    UniProtKB/Swiss-Prot
    Q5TGY1, Q5TGY2, Q6MZN5, Q7Z6K6, Q9UQP4, Q9Y3K1
    UniProtKB/TrEMBL
    A0A075B6H3
    Conserved Domains (1) summary
    cl21494
    Location:185 → 521
    Abhydrolase; alpha/beta hydrolases

  2. XM_047416926.1 → XP_047272882.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

  3. XM_011541181.2 → XP_011539483.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011539483.1

    Conserved Domains (1) summary
    pfam05277
    Location:285 → 621
    DUF726; Protein of unknown function (DUF726)

  4. XM_011541179.3 → XP_011539481.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011539481.1

    Conserved Domains (1) summary
    pfam05277
    Location:285 → 621
    DUF726; Protein of unknown function (DUF726)

  5. XM_017000916.2 → XP_016856405.1  transmembrane and coiled-coil domain-containing protein 4 isoform X2

  6. XM_011541180.3 → XP_011539482.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011539482.1

    Conserved Domains (1) summary
    pfam05277
    Location:285 → 621
    DUF726; Protein of unknown function (DUF726)

  7. XM_047416943.1 → XP_047272899.1  transmembrane and coiled-coil domain-containing protein 4 isoform X5

    UniProtKB/Swiss-Prot
    Q5TGY1, Q5TGY2, Q6MZN5, Q7Z6K6, Q9UQP4, Q9Y3K1

  8. XM_047416922.1 → XP_047272878.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

  9. XM_047416936.1 → XP_047272892.1  transmembrane and coiled-coil domain-containing protein 4 isoform X5

    UniProtKB/Swiss-Prot
    Q5TGY1, Q5TGY2, Q6MZN5, Q7Z6K6, Q9UQP4, Q9Y3K1

  10. XM_047416933.1 → XP_047272889.1  transmembrane and coiled-coil domain-containing protein 4 isoform X3

  11. XM_017000917.2 → XP_016856406.1  transmembrane and coiled-coil domain-containing protein 4 isoform X4

    Conserved Domains (1) summary
    pfam05277
    Location:244 → 580
    DUF726; Protein of unknown function (DUF726)

  12. XM_047416948.1 → XP_047272904.1  transmembrane and coiled-coil domain-containing protein 4 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    19505616..19623756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335778.1 → XP_054191753.1  transmembrane and coiled-coil domain-containing protein 4 isoform X5

  2. XM_054335770.1 → XP_054191745.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

  3. XM_054335777.1 → XP_054191752.1  transmembrane and coiled-coil domain-containing protein 4 isoform X5

  4. XM_054335771.1 → XP_054191746.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

  5. XM_054335768.1 → XP_054191743.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

  6. XM_054335766.1 → XP_054191741.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

  7. XM_054335772.1 → XP_054191747.1  transmembrane and coiled-coil domain-containing protein 4 isoform X2

  8. XM_054335767.1 → XP_054191742.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

  9. XM_054335776.1 → XP_054191751.1  transmembrane and coiled-coil domain-containing protein 4 isoform X5

  10. XM_054335769.1 → XP_054191744.1  transmembrane and coiled-coil domain-containing protein 4 isoform X1

  11. XM_054335775.1 → XP_054191750.1  transmembrane and coiled-coil domain-containing protein 4 isoform X5

  12. XM_054335773.1 → XP_054191748.1  transmembrane and coiled-coil domain-containing protein 4 isoform X3

  13. XM_054335774.1 → XP_054191749.1  transmembrane and coiled-coil domain-containing protein 4 isoform X4

  14. XM_054335779.1 → XP_054191754.1  transmembrane and coiled-coil domain-containing protein 4 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5TGY1.1 GenPept UniProtKB/Swiss-Prot:Q5TGY1

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