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LPCAT4 lysophosphatidylcholine acyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 254531, updated on 3-Apr-2024

Summary

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Official Symbol
LPCAT4provided by HGNC
Official Full Name
lysophosphatidylcholine acyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:30059
See related
Ensembl:ENSG00000176454 MIM:612039; AllianceGenome:HGNC:30059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AYTL3; AGPAT7; LPEAT2; LPLAT10; LPAAT-eta
Summary
Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]
Expression
Ubiquitous expression in stomach (RPKM 27.5), duodenum (RPKM 20.5) and 23 other tissues See more
Orthologs
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Genomic context

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See LPCAT4 in Genome Data Viewer
Location:
15q14
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (34358633..34367196, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (32159092..32167666, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34650834..34659397, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6279 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6280 Neighboring gene NOP10 ribonucleoprotein Neighboring gene NUT midline carcinoma family member 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:34645972-34647171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6283 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:34659557-34660552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9181 Neighboring gene actin gamma 1 pseudogene 15 Neighboring gene golgin A8 family member A Neighboring gene microRNA 1233-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LPCAT4 Knockdown Alters Barrier Integrity and Cellular Bioenergetics in Human Urothelium. Mason AS, et al. Int J Mol Sci, 2022 Oct 6. PMID 36233185, Free PMC Article
  2. Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4. Kurabe N, et al. Cancer Sci, 2013 Oct. PMID 23815430, Free PMC Article
  3. Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7. Ye GM, et al. DNA Seq, 2005 Oct. PMID 16243729
  4. Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2. Cao J, et al. J Biol Chem, 2008 Jul 4. PMID 18458083
  5. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Adams MD, et al. Nature, 1995 Sep 28. PMID 7566098

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LPCAT4 Knockdown Alters Barrier Integrity and Cellular Bioenergetics in Human Urothelium.
    Title: LPCAT4 Knockdown Alters Barrier Integrity and Cellular Bioenergetics in Human Urothelium.
  2. LPCAT4 is overexpressed and involved in the deregulation of PC(16:0/16:1) in colorectal cancer.
    Title: Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4.
  3. LPEAT2 as an important enzyme in the biosynthesis of ethanolamine-containing phospholipids, especially in brain.
    Title: Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2.
  4. report the cloning and characterization of a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase member AGPAT7 (1-acyl-sn-glycerol-3-phosphate acyltransferase 7) gene, which was mapped to human chromosome 15q14
    Title: Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10257

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
  
enables 1-acylglycerophosphocholine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-acylglycerophosphoserine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-alkenylglycerophosphoethanolamine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-alkylglycerophosphocholine O-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-acylglycerol-3-phosphate O-acyltransferase activity TAS
Traceable Author Statement
more info
  
enables lysophosphatidic acid acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophospholipid acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophospholipid acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in phosphatidylcholine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
  
involved_in phosphatidylethanolamine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
  
involved_in phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
  
involved_in phosphatidylserine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
  
acts_upstream_of_or_within phospholipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
lysophospholipid acyltransferase LPCAT4
Names
1-AGP acyltransferase 7
1-AGPAT 7
1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)
1-acylglycerophosphocholine O-acyltransferase
1-acylglycerophosphoserine O-acyltransferase
1-alkenylglycerophosphoethanolamine O-acyltransferase
1-alkylglycerophosphocholine O-acetyltransferase
PLSC domain containing protein
acyl-CoA:lysophosphatidylethanolamine acyltransferase 2
acyltransferase-like 3
lysophosphatidylethanolamine acyltransferase 2
lysophospholipid acyltransferase 10
plasmalogen synthase
NP_705841.2
XP_006720517.1
XP_047288290.1
XP_054189157.1
XP_054189158.1
XP_054233625.1
XP_054233626.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153613.3 → NP_705841.2  lysophospholipid acyltransferase LPCAT4

    See identical proteins and their annotated locations for NP_705841.2

    Status: VALIDATED

    Source sequence(s)
    AC025678, BC048430, BC092463, T29943
    Consensus CDS
    CCDS32191.1
    UniProtKB/Swiss-Prot
    A8K2K8, O43412, Q643R3, Q7Z4P4, Q8IUL7, Q8TB38
    Related
    ENSP00000317300.6, ENST00000314891.11
    Conserved Domains (1) summary
    cd07991
    Location:109 → 306
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    34358633..34367196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432334.1 → XP_047288290.1  lysophospholipid acyltransferase LPCAT4 isoform X1

  2. XM_006720454.2 → XP_006720517.1  lysophospholipid acyltransferase LPCAT4 isoform X2

    UniProtKB/TrEMBL
    B7ZM32
    Conserved Domains (2) summary
    cd07991
    Location:109 → 306
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    COG0204
    Location:109 → 237
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

RNA

  1. XR_007064436.1 RNA Sequence

  2. XR_931784.2 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791798.1 Reference GRCh38.p14 PATCHES

    Range
    99459..108034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333182.1 → XP_054189157.1  lysophospholipid acyltransferase LPCAT4 isoform X1

  2. XM_054333183.1 → XP_054189158.1  lysophospholipid acyltransferase LPCAT4 isoform X2

RNA

  1. XR_008485830.1 RNA Sequence

  2. XR_008485831.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    32159092..32167666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377650.1 → XP_054233625.1  lysophospholipid acyltransferase LPCAT4 isoform X1

  2. XM_054377651.1 → XP_054233626.1  lysophospholipid acyltransferase LPCAT4 isoform X2

RNA

  1. XR_008488934.1 RNA Sequence

  2. XR_008488935.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q643R3.1 GenPept UniProtKB/Swiss-Prot:Q643R3

Gene LinkOut

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