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PROSER2 proline and serine rich 2 [ Homo sapiens (human) ]

Gene ID: 254427, updated on 7-Apr-2024

Summary

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Official Symbol
PROSER2provided by HGNC
Official Full Name
proline and serine rich 2provided by HGNC
Primary source
HGNC:HGNC:23728
See related
Ensembl:ENSG00000148426 AllianceGenome:HGNC:23728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf47
Expression
Broad expression in liver (RPKM 3.3), placenta (RPKM 2.8) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
10p14
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (11823356..11872277)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (11834808..11883725)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (11865355..11914276)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379850 Neighboring gene uncharacterized LOC105376415 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:11835512-11836711 Neighboring gene PROSER2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:11917739-11918586 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:11923543-11924742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3027 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:11940130-11941329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3028 Neighboring gene RNA, U6 small nuclear 1095, pseudogene Neighboring gene UPF2 regulator of nonsense mediated mRNA decay Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3031 Neighboring gene uncharacterized LOC105376416

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2. Wang C, et al. Nat Commun, 2020 Jun 22. PMID 32572027, Free PMC Article
  2. The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer. Tang W, et al. Nat Commun, 2019 Feb 8. PMID 30737378, Free PMC Article
  3. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Lee OH, et al. Mol Cell Proteomics, 2011 Feb. PMID 21044950, Free PMC Article
  4. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  5. Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling. Zhai Y, et al. Nat Commun, 2022 Aug 20. PMID 35987950, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. New Function Annotation of PROSER2 in Pancreatic Ductal Adenocarcinoma.
    Title: New Function Annotation of PROSER2 in Pancreatic Ductal Adenocarcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC35403

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
proline and serine-rich protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153256.4 → NP_694988.3  proline and serine-rich protein 2

    See identical proteins and their annotated locations for NP_694988.3

    Status: VALIDATED

    Source sequence(s)
    AL138898, BC048800
    Consensus CDS
    CCDS7085.1
    UniProtKB/Swiss-Prot
    D3DRR8, Q5W0J9, Q5W0K0, Q5W0K1, Q5W0K2, Q6PJC8, Q86WR7, Q8N317
    Related
    ENSP00000277570.5, ENST00000277570.10
    Conserved Domains (2) summary
    PHA03247
    Location:92 → 405
    PHA03247; large tegument protein UL36; Provisional
    pfam15385
    Location:396 → 433
    SARG; Specifically androgen-regulated gene protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    11823356..11872277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519438.3 → XP_011517740.1  proline and serine-rich protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011517740.1

    UniProtKB/Swiss-Prot
    D3DRR8, Q5W0J9, Q5W0K0, Q5W0K1, Q5W0K2, Q6PJC8, Q86WR7, Q8N317
    Conserved Domains (2) summary
    PHA03247
    Location:92 → 405
    PHA03247; large tegument protein UL36; Provisional
    pfam15385
    Location:396 → 433
    SARG; Specifically androgen-regulated gene protein

  2. XM_047424963.1 → XP_047280919.1  proline and serine-rich protein 2 isoform X2

    UniProtKB/TrEMBL
    D3DRR9
    Related
    ENSP00000368498.1, ENST00000379200.1

  3. XM_047424964.1 → XP_047280920.1  proline and serine-rich protein 2 isoform X2

    UniProtKB/TrEMBL
    D3DRR9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    11834808..11883725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365416.1 → XP_054221391.1  proline and serine-rich protein 2 isoform X1

    UniProtKB/Swiss-Prot
    D3DRR8, Q5W0J9, Q5W0K0, Q5W0K1, Q5W0K2, Q6PJC8, Q86WR7, Q8N317

  2. XM_054365417.1 → XP_054221392.1  proline and serine-rich protein 2 isoform X1

    UniProtKB/Swiss-Prot
    D3DRR8, Q5W0J9, Q5W0K0, Q5W0K1, Q5W0K2, Q6PJC8, Q86WR7, Q8N317

  3. XM_054365418.1 → XP_054221393.1  proline and serine-rich protein 2 isoform X2

    UniProtKB/TrEMBL
    D3DRR9

  4. XM_054365419.1 → XP_054221394.1  proline and serine-rich protein 2 isoform X2

    UniProtKB/TrEMBL
    D3DRR9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86WR7.2 GenPept UniProtKB/Swiss-Prot:Q86WR7

Gene LinkOut

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