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TSGA10IP testis specific 10 interacting protein [ Homo sapiens (human) ]

Gene ID: 254187, updated on 7-Apr-2024

Summary

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Official Symbol
TSGA10IPprovided by HGNC
Official Full Name
testis specific 10 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:26555
See related
Ensembl:ENSG00000175513 AllianceGenome:HGNC:26555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM161C
Summary
Predicted to be involved in cilium organization. Predicted to be active in photoreceptor connecting cilium. Predicted to colocalize with ciliary basal body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 2.7) See more
Orthologs
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Genomic context

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Location:
11q13.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65945480..65959966)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65938560..65953047)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65712951..65727437)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:65685650-65686569 and GRCh37_chr11:65686570-65687490 Neighboring gene chromosome 11 open reading frame 68 Neighboring gene DR1 associated protein 1 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3343 Neighboring gene NANOG hESC enhancer GRCh37_chr11:65704708-65705232 Neighboring gene uncharacterized LOC105369350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65708489-65708988 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:65708959-65709182 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:65729063-65729850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65733572-65734072 Neighboring gene spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas. Abraham CG, et al. Cell Rep, 2018 Sep 18. PMID 30232004, Free PMC Article
  2. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Hill SJ, et al. Genes Dev, 2014 Sep 1. PMID 25184681, Free PMC Article
  3. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32880, MGC120465, MGC120466, MGC120468

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
colocalizes_with ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in photoreceptor connecting cilium IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
testis-specific protein 10-interacting protein
Names
tsga10-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395491.1 → NP_001382420.1  testis-specific protein 10-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AP006287, KF459671

  2. NM_001395492.1 → NP_001382421.1  testis-specific protein 10-interacting protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AP006287, KF459671

  3. NM_001395493.1 → NP_001382422.1  testis-specific protein 10-interacting protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AP006287, KF459671

  4. NM_001395494.1 → NP_001382423.1  testis-specific protein 10-interacting protein isoform d

    Status: VALIDATED

    Source sequence(s)
    AP006287, KF459671

  5. NM_001395495.1 → NP_001382424.1  testis-specific protein 10-interacting protein isoform e

    Status: VALIDATED

    Source sequence(s)
    AP006287, KF459671

  6. NM_152762.3 → NP_689975.2  testis-specific protein 10-interacting protein isoform b

    See identical proteins and their annotated locations for NP_689975.2

    Status: VALIDATED

    Source sequence(s)
    AP006287, KF459671
    Consensus CDS
    CCDS66138.1
    UniProtKB/Swiss-Prot
    Q3SXZ9, Q3SY00, Q3SY01, Q96M26
    Related
    ENSP00000484252.1, ENST00000532620.6

RNA

  1. NR_172563.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP006287, KF459671
    Related
    ENST00000534740.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    65945480..65959966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426706.1 → XP_047282662.1  testis-specific protein 10-interacting protein isoform X1

RNA

  1. XR_949858.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    65938560..65953047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368298.1 → XP_054224273.1  testis-specific protein 10-interacting protein isoform X1

RNA

  1. XR_008488375.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3SY00.2 GenPept UniProtKB/Swiss-Prot:Q3SY00

Gene LinkOut

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