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WDR27 WD repeat domain 27 [ Homo sapiens (human) ]

Gene ID: 253769, updated on 3-Apr-2024

Summary

Official Symbol
WDR27provided by HGNC
Official Full Name
WD repeat domain 27provided by HGNC
Primary source
HGNC:HGNC:21248
See related
Ensembl:ENSG00000184465 AllianceGenome:HGNC:21248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein with multiple WD repeats. Proteins with these repeats may form scaffolds for protein-protein interaction and play key roles in cell signalling. Alternative splicing results in multiple transcript variants, but the full-length structure of some of these variants cannot be determined. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in testis (RPKM 1.4), ovary (RPKM 1.4) and 25 other tissues See more
Orthologs
NEW
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Genomic context

See WDR27 in Genome Data Viewer
Location:
6q27
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (169426420..169702029, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (170780064..171055943, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (169857307..170102125, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:169780895-169781395 Neighboring gene long intergenic non-protein coding RNA 2519 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:169795407-169796606 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:169811859-169812052 Neighboring gene uncharacterized LOC124901473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:169829202-169829769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:169849141-169850015 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:169850016-169850889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:169952752-169953720 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:169956378-169956538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:169964074-169964574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17796 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:170017112-170017650 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:170019030-170019674 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:170019675-170020319 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170024255-170024754 Neighboring gene uncharacterized LOC124901471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170040667-170041282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170047131-170048124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25463 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:170056229-170057024 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:170057025-170057820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170061015-170061514 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:170062913-170064112 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:170067058-170067246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170067590-170068090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170068091-170068591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170092723-170093223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:170124719-170125261 Neighboring gene chromosome 6 open reading frame 120 Neighboring gene PHD finger protein 10 Neighboring gene MPRA-validated peak6328 silencer Neighboring gene dynein light chain Tctex-type 2 Neighboring gene ER membrane associated RNA degradation

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
EBI GWAS Catalog
Common genetic variation and the control of HIV-1 in humans.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC43690

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
WD repeat-containing protein 27

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046155.1 RefSeqGene

    Range
    5035..249852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1071

mRNA and Protein(s)

  1. NM_001202550.2NP_001189479.1  WD repeat-containing protein 27 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three alternate exons that result in the loss of an in-frame segment in the 5' coding region, and lacks another alternate exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL513547, AW194823, BC131633, DB292377
    Consensus CDS
    CCDS56459.1
    UniProtKB/Swiss-Prot
    A2RRH5, A5PLM8, C9JGV0, Q5T066
    Related
    ENSP00000397869.1, ENST00000423258.5
    Conserved Domains (3) summary
    COG2319
    Location:454727
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:419456
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:418727
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001350623.2NP_001337552.1  WD repeat-containing protein 27 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL031315, AL135910, AL513547
    UniProtKB/Swiss-Prot
    A2RRH5, A5PLM8, C9JGV0, Q5T066
    Conserved Domains (2) summary
    sd00039
    Location:355392
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:354663
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001350624.2NP_001337553.1  WD repeat-containing protein 27 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variant 5, encodes isoform 4.
    Source sequence(s)
    AL513547
    Consensus CDS
    CCDS94039.1
    UniProtKB/TrEMBL
    A0A3B3ITF5
    Related
    ENSP00000497692.1, ENST00000647873.1
    Conserved Domains (2) summary
    sd00039
    Location:3269
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:39204
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_001350625.2NP_001337554.1  WD repeat-containing protein 27 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 4, encodes isoform 4.
    Source sequence(s)
    AL513547
    Consensus CDS
    CCDS94039.1
    UniProtKB/TrEMBL
    A0A3B3ITF5
    Conserved Domains (2) summary
    sd00039
    Location:3269
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:39204
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. NM_182552.5NP_872358.4  WD repeat-containing protein 27 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL031315, AL513547, BC040606, DB292377
    Consensus CDS
    CCDS47520.2
    UniProtKB/Swiss-Prot
    A2RRH5, A5PLM8, C9JGV0, Q5T066
    Related
    ENSP00000416289.1, ENST00000448612.6
    Conserved Domains (4) summary
    COG2319
    Location:544865
    WD40; WD40 repeat [General function prediction only]
    pfam13900
    Location:847881
    GVQW; Putative domain of unknown function
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545842
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_146875.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031315, AL135910, AL513547
    Related
    ENST00000648472.1
  2. NR_146876.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL513547
    Related
    ENST00000649303.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    169426420..169702029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535688.4XP_011533990.1  WD repeat-containing protein 27 isoform X6

    See identical proteins and their annotated locations for XP_011533990.1

    UniProtKB/Swiss-Prot
    A2RRH5, A5PLM8, C9JGV0, Q5T066
    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545853
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_011535687.4XP_011533989.1  WD repeat-containing protein 27 isoform X6

    See identical proteins and their annotated locations for XP_011533989.1

    UniProtKB/Swiss-Prot
    A2RRH5, A5PLM8, C9JGV0, Q5T066
    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545853
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_017010669.2XP_016866158.1  WD repeat-containing protein 27 isoform X12

    UniProtKB/Swiss-Prot
    A2RRH5, A5PLM8, C9JGV0, Q5T066
    Conserved Domains (2) summary
    sd00039
    Location:355392
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:354663
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_017010660.3XP_016866149.1  WD repeat-containing protein 27 isoform X5

    UniProtKB/Swiss-Prot
    A2RRH5, A5PLM8, C9JGV0, Q5T066
    Conserved Domains (3) summary
    COG2319
    Location:581854
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545854
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_011535691.4XP_011533993.1  WD repeat-containing protein 27 isoform X7

    UniProtKB/Swiss-Prot
    A2RRH5, A5PLM8, C9JGV0, Q5T066
    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:579838
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_047418584.1XP_047274540.1  WD repeat-containing protein 27 isoform X3

  7. XM_011535692.4XP_011533994.1  WD repeat-containing protein 27 isoform X8

    UniProtKB/Swiss-Prot
    A2RRH5, A5PLM8, C9JGV0, Q5T066
    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545842
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_011535685.4XP_011533987.1  WD repeat-containing protein 27 isoform X4

    UniProtKB/Swiss-Prot
    A2RRH5, A5PLM8, C9JGV0, Q5T066
    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:579838
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. XM_011535682.4XP_011533984.1  WD repeat-containing protein 27 isoform X1

    UniProtKB/Swiss-Prot
    A2RRH5, A5PLM8, C9JGV0, Q5T066
    Conserved Domains (3) summary
    COG2319
    Location:544885
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545842
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. XM_011535684.4XP_011533986.1  WD repeat-containing protein 27 isoform X2

    UniProtKB/Swiss-Prot
    A2RRH5, A5PLM8, C9JGV0, Q5T066
    Conserved Domains (3) summary
    COG2319
    Location:544838
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:546583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:545842
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  11. XM_047418586.1XP_047274542.1  WD repeat-containing protein 27 isoform X11

  12. XM_011535693.4XP_011533995.1  WD repeat-containing protein 27 isoform X9

    UniProtKB/Swiss-Prot
    A2RRH5, A5PLM8, C9JGV0, Q5T066
    Conserved Domains (3) summary
    COG2319
    Location:544750
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:3269
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:48266
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  13. XM_047418585.1XP_047274541.1  WD repeat-containing protein 27 isoform X10

  14. XM_047418587.1XP_047274543.1  WD repeat-containing protein 27 isoform X13

  15. XM_017010672.3XP_016866161.1  WD repeat-containing protein 27 isoform X14

  16. XM_011535697.4XP_011533999.1  WD repeat-containing protein 27 isoform X17

    Conserved Domains (3) summary
    COG2319
    Location:15356
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:3269
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:48266
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  17. XM_047418590.1XP_047274546.1  WD repeat-containing protein 27 isoform X16

  18. XM_047418588.1XP_047274544.1  WD repeat-containing protein 27 isoform X15

  19. XM_047418589.1XP_047274545.1  WD repeat-containing protein 27 isoform X16

RNA

  1. XR_007059231.1 RNA Sequence

  2. XR_007059230.1 RNA Sequence

  3. XR_007059233.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    170780064..171055943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355043.1XP_054211018.1  WD repeat-containing protein 27 isoform X6

  2. XM_054355042.1XP_054211017.1  WD repeat-containing protein 27 isoform X6

  3. XM_054355049.1XP_054211024.1  WD repeat-containing protein 27 isoform X12

  4. XM_054355041.1XP_054211016.1  WD repeat-containing protein 27 isoform X5

  5. XM_054355044.1XP_054211019.1  WD repeat-containing protein 27 isoform X7

  6. XM_054355040.1XP_054211015.1  WD repeat-containing protein 27 isoform X3

  7. XM_054355045.1XP_054211020.1  WD repeat-containing protein 27 isoform X8

  8. XM_054355038.1XP_054211013.1  WD repeat-containing protein 27 isoform X1

  9. XM_054355039.1XP_054211014.1  WD repeat-containing protein 27 isoform X2

  10. XM_054355048.1XP_054211023.1  WD repeat-containing protein 27 isoform X11

  11. XM_054355046.1XP_054211021.1  WD repeat-containing protein 27 isoform X9

  12. XM_054355047.1XP_054211022.1  WD repeat-containing protein 27 isoform X10

  13. XM_054355050.1XP_054211025.1  WD repeat-containing protein 27 isoform X13

  14. XM_054355051.1XP_054211026.1  WD repeat-containing protein 27 isoform X14

  15. XM_054355055.1XP_054211030.1  WD repeat-containing protein 27 isoform X17

  16. XM_054355054.1XP_054211029.1  WD repeat-containing protein 27 isoform X16

  17. XM_054355052.1XP_054211027.1  WD repeat-containing protein 27 isoform X15

  18. XM_054355053.1XP_054211028.1  WD repeat-containing protein 27 isoform X16

RNA

  1. XR_008487290.1 RNA Sequence

  2. XR_008487289.1 RNA Sequence

  3. XR_008487291.1 RNA Sequence