IFI6 interferon alpha inducible protein 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IFI6provided by HGNC
Official Full Name: interferon alpha inducible protein 6provided by HGNC
Primary source: HGNC:HGNC:4054
See related: Ensembl:ENSG00000126709 MIM:147572; AllianceGenome:HGNC:4054
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: 6-16; G1P3; FAM14C; IFI616; IFI-6-16
Summary: This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]
Expression: Broad expression in placenta (RPKM 111.6), salivary gland (RPKM 40.6) and 21 other tissues See more
Orthologs: all
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Genomic context

Location:: 1p35.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (27666064..27672192, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (27507374..27513475, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (27992575..27998703, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of glucose-dependent insulinotropic polypeptide 3 (G1P-3) and nucleolar phosphoprotein-1 (NPM1) in pathogenesis of psoriasis.
Title: The role of glucose-dependent insulinotropic polypeptide 3 (G1P-3) and nucleolar phosphoprotein-1 (NPM1) in pathogenesis of psoriasis.
BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6.
Title: BM-MSCs display altered gene expression profiles in B-cell acute lymphoblastic leukemia niches and exert pro-proliferative effects via overexpression of IFI6.
Role of interferon alpha-inducible protein 6 in modulating the proliferation, apoptosis and senescence of oesophageal squamous cell carcinoma cells.
Title: Role of interferon alpha-inducible protein 6 in modulating the proliferation, apoptosis and senescence of oesophageal squamous cell carcinoma cells.
Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation.
Title: Interferon alpha inducible protein 6 is a negative regulator of innate immune responses by modulating RIG-I activation.
IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of gamma-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement.
Title: IDO1, FAT10, IFI6, and GILT Are Involved in the Antiretroviral Activity of γ-Interferon and IDO1 Restricts Retrovirus Infection by Autophagy Enhancement.
The Functional and Antiviral Activity of Interferon Alpha-Inducible IFI6 Against Hepatitis B Virus Replication and Gene Expression.
Title: The Functional and Antiviral Activity of Interferon Alpha-Inducible IFI6 Against Hepatitis B Virus Replication and Gene Expression.
Interferon-alpha inducible protein 6 (IFI6) confers protection against ionizing radiation in skin cells.
Title: Interferon-α inducible protein 6 (IFI6) confers protection against ionizing radiation in skin cells.
ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells.
Title: ATF3 downmodulates its new targets IFI6 and IFI27 to suppress the growth and migration of tongue squamous cell carcinoma cells.
IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress.
Title: IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress.
G1P3-induced mtROS have a direct role in migratory structure formation and nuclear gene expression to promote breast cancer cell metastasis. Therefore, interrupting mitochondrial functions of G1P3 may improve clinical outcomes in breast cancer patients
Title: G1P3 (IFI6), a mitochondrial localised antiapoptotic protein, promotes metastatic potential of breast cancer cells through mtROS.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 LAI infection downregulates UBD (FAT10) and IFI6 mRNA levels in HeLa cells, which results from IFNG signaling inhibition	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 downregulates the expression of interferon alpha-inducible protein 6 (IFI6) in human B cells	PubMed
Vpr	vpr	HIV-1 Vpr upregulates the gene expression of IFI6 in human monocyte-derived dendritic cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC299790P5 (e-PCR)
- UniSTS:272465

RH80818 (e-PCR)
- UniSTS:88701

PMC154027P1 (e-PCR)
- UniSTS:271284

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial depolarization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitochondrial depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of cytochrome c from mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: interferon alpha-inducible protein 6

Names: interferon, alpha-inducible protein clone IFI-6-16; interferon-induced protein 6-16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002038.4 → NP_002029.3 interferon alpha-inducible protein 6 isoform a precursor

See identical proteins and their annotated locations for NP_002029.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the shortest isoform (a).

Source sequence(s)

AK024814, AL445490

Consensus CDS

CCDS306.1

UniProtKB/Swiss-Prot

P09912, Q13141, Q13142, Q5VVR2, Q5VVR3, Q6IE95, Q969M8

UniProtKB/TrEMBL

A0A348GSI1

Related

ENSP00000354736.6, ENST00000361157.11

Conserved Domains (1) summary

pfam06140
Location:46 → 118

Ifi-6-16; Interferon-induced 6-16 family
NM_022872.3 → NP_075010.1 interferon alpha-inducible protein 6 isoform b precursor

See identical proteins and their annotated locations for NP_075010.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alterative, in-frame splice site compared to variant 1. The encoded isoform (b) is longer than isoform a.

Source sequence(s)

AK024814, AL445490

Consensus CDS

CCDS307.1

UniProtKB/Swiss-Prot

P09912

Related

ENSP00000355152.4, ENST00000362020.4

Conserved Domains (1) summary

pfam06140
Location:50 → 111

Ifi-6-16; Interferon-induced 6-16 family
NM_022873.3 → NP_075011.1 interferon alpha-inducible protein 6 isoform c precursor

See identical proteins and their annotated locations for NP_075011.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alterative, in-frame splice site compared to variant 1. The encoded isoform (c) is longer than isoform a.

Source sequence(s)

AK024814, AL445490

Consensus CDS

CCDS308.1

UniProtKB/Swiss-Prot

P09912

Related

ENSP00000342513.4, ENST00000339145.8

Conserved Domains (1) summary

pfam06140
Location:54 → 115

Ifi-6-16; Interferon-induced 6-16 family