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SERHL2 serine hydrolase like 2 [ Homo sapiens (human) ]

Gene ID: 253190, updated on 3-Apr-2024

Summary

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Official Symbol
SERHL2provided by HGNC
Official Full Name
serine hydrolase like 2provided by HGNC
Primary source
HGNC:HGNC:29446
See related
Ensembl:ENSG00000183569 MIM:619045; AllianceGenome:HGNC:29446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ222E13.1
Summary
Predicted to enable hydrolase activity. Predicted to be located in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 8.8), ovary (RPKM 8.8) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
22q13.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (42553956..42574382)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (43034822..43055247)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (42949962..42970388)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42900600-42901233 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42904339-42905038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42905039-42905737 Neighboring gene serine hydrolase like (pseudogene) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:42909821-42910364 Neighboring gene uncharacterized LOC124900479 Neighboring gene ribosomal RNA processing 7 homolog A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13827 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19168 Neighboring gene Sharpr-MPRA regulatory region 9885 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42923851-42924598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42929412-42929912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42929913-42930413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:42956436-42957120 Neighboring gene RN7SK pseudogene 80 Neighboring gene RNA, U6 small nuclear 513, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13831 Neighboring gene ribosomal RNA processing 7 homolog B, pseudogene Neighboring gene DNA polymerase delta interacting protein 3 Neighboring gene Sharpr-MPRA regulatory region 2357 Neighboring gene uncharacterized LOC124905127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:43009109-43009652 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:43010197-43010740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:43010741-43011284 Neighboring gene RNA, U12 small nuclear

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of Serhl, a new member of the serine hydrolase family induced by passive stretch of skeletal muscle in vivo. Sadusky TJ, et al. Genomics, 2001 Apr 1. PMID 11352564
  2. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. Collins JE, et al. Genome Res, 2003 Jan. PMID 12529303, Free PMC Article
  3. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Hu Q, et al. Cell Res, 2019 Apr. PMID 30631154, Free PMC Article
  4. A genome annotation-driven approach to cloning the human ORFeome. Collins JE, et al. Genome Biol, 2004. PMID 15461802, Free PMC Article
  5. The DNA sequence of human chromosome 22. Dunham I, et al. Nature, 1999 Dec 2. PMID 10591208

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC149508, MGC157667, MGC157668

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine hydrolase-like protein 2
Names
testis secretory sperm-binding protein Li 216e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284334.2 → NP_001271263.1  serine hydrolase-like protein 2 isoform b

    See identical proteins and their annotated locations for NP_001271263.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AL590118, AW134760, DC315058
    Consensus CDS
    CCDS63498.1
    UniProtKB/Swiss-Prot
    Q9H4I8
    Related
    ENSP00000336578.5, ENST00000335879.5
    Conserved Domains (1) summary
    COG0596
    Location:6 → 241
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

  2. NM_014509.5 → NP_055324.2  serine hydrolase-like protein 2 isoform a

    See identical proteins and their annotated locations for NP_055324.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL450314, AW134760
    Consensus CDS
    CCDS14037.1
    UniProtKB/Swiss-Prot
    B1AHE9, B1AHF0, Q0VDJ1, Q5H973, Q9BR29, Q9BR30, Q9H4I8, Q9Y3I9
    UniProtKB/TrEMBL
    A0A140VK89, Q0VDJ0
    Related
    ENSP00000331376.5, ENST00000327678.10
    Conserved Domains (1) summary
    COG0596
    Location:21 → 305
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

RNA

  1. NR_104300.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in both the 5' and 3' regions, and lacks an exon in the central region, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294584, AL450314, AW134760

  2. NR_104301.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the central region and uses an alternate splice site in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294584, AW134760, BC041802, DC315058
    Related
    ENST00000477564.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    42553956..42574382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452196.2 → XP_024307964.1  serine hydrolase-like protein 2 isoform X1

    UniProtKB/TrEMBL
    Q0VDJ0
    Conserved Domains (1) summary
    COG0596
    Location:21 → 332
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

  2. XM_047441295.1 → XP_047297251.1  serine hydrolase-like protein 2 isoform X2

  3. XM_047441298.1 → XP_047297254.1  serine hydrolase-like protein 2 isoform X5

  4. XM_017028739.3 → XP_016884228.1  serine hydrolase-like protein 2 isoform X6

    UniProtKB/TrEMBL
    Q0VDJ0

  5. XM_047441296.1 → XP_047297252.1  serine hydrolase-like protein 2 isoform X3

  6. XM_047441297.1 → XP_047297253.1  serine hydrolase-like protein 2 isoform X4

  7. XM_047441301.1 → XP_047297257.1  serine hydrolase-like protein 2 isoform X9

    UniProtKB/TrEMBL
    A6ND93
    Related
    ENSP00000342425.4, ENST00000340239.8

  8. XM_047441300.1 → XP_047297256.1  serine hydrolase-like protein 2 isoform X8

  9. XM_047441299.1 → XP_047297255.1  serine hydrolase-like protein 2 isoform X7

RNA

  1. XR_001755198.3 RNA Sequence

  2. XR_007067968.1 RNA Sequence

  3. XR_007067966.1 RNA Sequence

  4. XR_007067967.1 RNA Sequence

  5. XR_007067969.1 RNA Sequence

    Related
    ENST00000416156.6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    43034822..43055247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325447.1 → XP_054181422.1  serine hydrolase-like protein 2 isoform X1

  2. XM_054325448.1 → XP_054181423.1  serine hydrolase-like protein 2 isoform X2

  3. XM_054325451.1 → XP_054181426.1  serine hydrolase-like protein 2 isoform X5

  4. XM_054325452.1 → XP_054181427.1  serine hydrolase-like protein 2 isoform X6

  5. XM_054325449.1 → XP_054181424.1  serine hydrolase-like protein 2 isoform X3

  6. XM_054325446.1 → XP_054181421.1  serine hydrolase-like protein 2 isoform X10

  7. XM_054325450.1 → XP_054181425.1  serine hydrolase-like protein 2 isoform X4

  8. XM_054325455.1 → XP_054181430.1  serine hydrolase-like protein 2 isoform X9

    UniProtKB/TrEMBL
    A6ND93

  9. XM_054325454.1 → XP_054181429.1  serine hydrolase-like protein 2 isoform X8

  10. XM_054325453.1 → XP_054181428.1  serine hydrolase-like protein 2 isoform X7

RNA

  1. XR_008485380.1 RNA Sequence

  2. XR_008485381.1 RNA Sequence

  3. XR_008485378.1 RNA Sequence

  4. XR_008485379.1 RNA Sequence

  5. XR_008485382.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H4I8.1 GenPept UniProtKB/Swiss-Prot:Q9H4I8

Gene LinkOut

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