Ropn1l ropporin 1-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ropn1lprovided by MGI
Official Full Name: ropporin 1-likeprovided by MGI
Primary source: MGI:MGI:2182357
See related: Ensembl:ENSMUSG00000022236 AllianceGenome:MGI:2182357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ASP; Akapasp
Summary: Predicted to enable identical protein binding activity. Acts upstream of or within flagellated sperm motility; regulation of protein phosphorylation; and sperm capacitation. Located in motile cilium. Is expressed in several structures, including heart; liver; lung; reproductive system; and spleen. Orthologous to human ROPN1L (rhophilin associated tail protein 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 542.1) See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 15 B2; 15 12.94 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (31441356..31453835, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (31441210..31453689, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutations in ROPN1 and ROPN1L can cause defects in fibrous sheath integrity, sperm motility, and PKA-dependent signaling processes, leading to male infertility.
Title: Loss of R2D2 proteins ROPN1 and ROPN1L causes defects in murine sperm motility, phosphorylation, and fibrous sheath integrity.
The beat frequency of cilia from mice lacking ASP is significantly slower than wild type, indicating that ASP signaling may regulate ciliary motility.
Title: Loss of ASP but not ROPN1 reduces mammalian ciliary motility.
Northern blot analysis of testis RNA from 5-, 15-, 25-, and 40-day-old mice showed expression of the ASP gene and in situ hybridization analysis localized the ASP mRNA to the germ cell compartment of the seminiferous tubules in the testis
Title: Identification of a murine testis complementary DNA encoding a homolog to human A-kinase anchoring protein-associated sperm protein.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)

General gene information

Go to the top of the page Help

Markers

AV047578 (e-PCR), detects polymorphism
- UniSTS:265250

AV047578 (e-PCR), detects polymorphism
- UniSTS:164575

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium movement	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cilium movement involved in extracellular fluid movement	IC Inferred by Curator more info	PubMed
involved_in flagellated sperm motility	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mating	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sperm capacitation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in 9+2 motile cilium	IC Inferred by Curator more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed
part_of radial spoke	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	IC Inferred by Curator more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: ropporin-1-like protein

Names: A-kinase anchoring protein-associated sperm protein; AKAP-associated sperm protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145852.2 → NP_665851.2 ropporin-1-like protein

See identical proteins and their annotated locations for NP_665851.2

Status: VALIDATED

Source sequence(s)

AK131675, AV039619

Consensus CDS

CCDS37053.1

UniProtKB/Swiss-Prot

Q6P8Z9, Q9EQ00

Related

ENSMUSP00000106038.2, ENSMUST00000110408.3

Conserved Domains (1) summary

cl02594
Location:15 → 51

DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains