Cables2 CDK5 and Abl enzyme substrate 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cables2provided by MGI
Official Full Name: CDK5 and Abl enzyme substrate 2provided by MGI
Primary source: MGI:MGI:2182335
See related: Ensembl:ENSMUSG00000038990 AllianceGenome:MGI:2182335
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ik3-2
Summary: Predicted to be involved in regulation of cell cycle. Predicted to act upstream of or within cell division. Orthologous to human CABLES2 (Cdk5 and Abl enzyme substrate 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 17.8), CNS E18 (RPKM 17.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 102.78 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (179900332..179915258, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (180258539..180273490, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway.
Title: Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway.
Characterization of a bicistronic knock-in reporter mouse model for investigating the role of CABLES2 in vivo.
Title: Characterization of a bicistronic knock-in reporter mouse model for investigating the role of CABLES2 in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: CDK5 and ABL1 enzyme substrate 2

Names: interactor with CDK3 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411354.1 → NP_001398283.1 CDK5 and ABL1 enzyme substrate 2 isoform 2

Status: VALIDATED

Source sequence(s)

AL663027
NM_001411357.1 → NP_001398286.1 CDK5 and ABL1 enzyme substrate 2 isoform 3

Status: VALIDATED

Source sequence(s)

AL663027
NM_001411361.1 → NP_001398290.1 CDK5 and ABL1 enzyme substrate 2 isoform 4

Status: VALIDATED

Source sequence(s)

AL663027
NM_001411365.1 → NP_001398294.1 CDK5 and ABL1 enzyme substrate 2 isoform 5

Status: VALIDATED

Source sequence(s)

AL663027
NM_145851.2 → NP_665850.2 CDK5 and ABL1 enzyme substrate 2 isoform 1

See identical proteins and their annotated locations for NP_665850.2

Status: VALIDATED

Source sequence(s)

AL663027

Consensus CDS

CCDS38377.1

UniProtKB/Swiss-Prot

A2ABW9, Q8K3M5

Related

ENSMUSP00000104519.2, ENSMUST00000108891.2

Conserved Domains (1) summary

cd00043
Location:360 → 416

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...