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Ackr4 atypical chemokine receptor 4 [ Mus musculus (house mouse) ]

Gene ID: 252837, updated on 21-Apr-2024

Summary

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Official Symbol
Ackr4provided by MGI
Official Full Name
atypical chemokine receptor 4provided by MGI
Primary source
MGI:MGI:2181676
See related
Ensembl:ENSMUSG00000079355 AllianceGenome:MGI:2181676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PPR1; CCBP2; CCR11; Ccrl1; VSHK1; CCX-CKR; Cmkbrl1; CCX-CKR1; A630091E18Rik
Summary
Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in endosome and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including central nervous system; gut; immune system; male reproductive gland or organ; and sensory organ. Orthologous to human ACKR4 (atypical chemokine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 3.0), colon adult (RPKM 2.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F1; 9 56.47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (103974881..104003842, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (104097682..104126643, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:103965595-103965778 Neighboring gene STARR-seq mESC enhancer starr_25105 Neighboring gene ubiquitin-like modifier activating enzyme 5 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 11 Neighboring gene STARR-seq mESC enhancer starr_25106 Neighboring gene STARR-seq mESC enhancer starr_25110 Neighboring gene DnaJ heat shock protein family (Hsp40) member C13 Neighboring gene high mobility group box 1, related sequence 16 Neighboring gene predicted gene, 46130

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration. Bastow CR, et al. Proc Natl Acad Sci U S A, 2021 Apr 27. PMID 33875601, Free PMC Article
  2. Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes. Fujimoto N, et al. PLoS Biol, 2020 Apr. PMID 32251437, Free PMC Article
  3. Expression of the Atypical Chemokine Receptor ACKR4 Identifies a Novel Population of Intestinal Submucosal Fibroblasts That Preferentially Expresses Endothelial Cell Regulators. Thomson CA, et al. J Immunol, 2018 Jul 1. PMID 29760193, Free PMC Article
  4. Atypical chemokine receptor 4 shapes activated B cell fate. Kara EE, et al. J Exp Med, 2018 Mar 5. PMID 29386231, Free PMC Article
  5. CCRL1/ACKR4 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice. Lucas B, et al. Eur J Immunol, 2015 Feb. PMID 25521433

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension.
    Title: Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension.
  2. Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics.
    Title: Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics.
  3. Expression of ACKR4 demarcates the ""peri-marginal sinus,"" a specialized vascular compartment of the splenic red pulp.
    Title: Expression of ACKR4 demarcates the "peri-marginal sinus," a specialized vascular compartment of the splenic red pulp.
  4. Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration.
    Title: Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration.
  5. Inhibition of fibroblast IL-6 production by ACKR4 deletion alleviates cardiac remodeling after myocardial infarction.
    Title: Inhibition of fibroblast IL-6 production by ACKR4 deletion alleviates cardiac remodeling after myocardial infarction.
  6. ACKR4 restrains antitumor immunity by regulating CCL21.
    Title: ACKR4 restrains antitumor immunity by regulating CCL21.
  7. CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4.
    Title: CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4.
  8. B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression.
    Title: B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression.
  9. atypical chemokine receptor 4 (ACKR4), is a identified a decoy receptor that binds and degrades CCR7 ligands CCL19/CCL21, as a regulator of early activated B cell differentiation.
    Title: Atypical chemokine receptor 4 shapes activated B cell fate.
  10. a comprehensive model of CCL19 and CCL21 transport and gradient formation in the lymph nodes (LNs) was built; predicts that ACKR4 in LNs prevents CCL19/CCL21 accumulation in efferent lymph, but does not control intranodal gradients; instead, it attributes the disrupted interfollicular CCL21 gradients observed in Ackr4-deficient LNs to ACKR4 loss upstream
    Title: A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables chemokine binding IEA
Inferred from Electronic Annotation
more info
  
enables chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
atypical chemokine receptor 4
Names
C-C CKR-11
C-C chemokine receptor type 11
CC chemokine receptor-like 1
CC-CKR-11
CCR-11
CCX CKR
chemokine (C-C motif) receptor-like 1
chemokine (C-C) receptor-like 1
chemokine receptor CCR11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145700.2 → NP_663746.2  atypical chemokine receptor 4

    See identical proteins and their annotated locations for NP_663746.2

    Status: VALIDATED

    Source sequence(s)
    AC145736, AK030643, AK042430, BB151172, BC140999
    Consensus CDS
    CCDS23459.1
    UniProtKB/Swiss-Prot
    Q8C0M1, Q8QZW9, Q924I3
    UniProtKB/TrEMBL
    B2RU75
    Related
    ENSMUSP00000075507.4, ENSMUST00000076147.6
    Conserved Domains (1) summary
    cd15176
    Location:42 → 314
    7tmA_ACKR4_CCR11; atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    103974881..104003842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511735.5 → XP_006511798.1  atypical chemokine receptor 4 isoform X1

    See identical proteins and their annotated locations for XP_006511798.1

    UniProtKB/Swiss-Prot
    Q8C0M1, Q8QZW9, Q924I3
    UniProtKB/TrEMBL
    B2RU75
    Related
    ENSMUSP00000140792.2, ENSMUST00000188000.2
    Conserved Domains (1) summary
    cd15176
    Location:42 → 314
    7tmA_ACKR4_CCR11; atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924I3.1 GenPept UniProtKB/Swiss-Prot:Q924I3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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