Il6st interleukin 6 cytokine family signal transducer [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il6stprovided by RGD
Official Full Name: interleukin 6 cytokine family signal transducerprovided by RGD
Primary source: RGD:2903
See related: Ensembl:ENSRNOG00000013963 AllianceGenome:RGD:2903
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gp130; Ac1055; Il-6rb
Summary: Predicted to enable several functions, including ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding activity; and scaffold protein binding activity. Predicted to contribute to cytokine receptor activity; growth factor binding activity; and interleukin-6 receptor binding activity. Involved in several processes, including interleukin-6-mediated signaling pathway; negative regulation of cytosolic calcium ion concentration; and triglyceride mobilization. Located in neuronal cell body membrane. Biomarker of brain ischemia; hepatocellular carcinoma; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; and hyperandrogenism. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 593.6), Liver (RPKM 564.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q14

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (45798872..45839501)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (44065979..44106255)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (44279199..44319427)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activating the interleukin-6-Gp130-STAT3 pathway ameliorates ventricular electrical stability in myocardial infarction rats by modulating neurotransmitters in the paraventricular nucleus.
Title: Activating the interleukin-6-Gp130-STAT3 pathway ameliorates ventricular electrical stability in myocardial infarction rats by modulating neurotransmitters in the paraventricular nucleus.
Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension.
Title: Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension.
pulmonary exposure to MWCNT can manifest as a reduced epithelial barrier and activator of vascular gp130-associated transsignaling that may promote susceptibility to cardiovascular derangements
Title: Pulmonary instillation of MWCNT increases lung permeability, decreases gp130 expression in the lungs, and initiates cardiovascular IL-6 transsignaling.
findings suggest a link between miR-17-5p increased expression and gp130/STAT3 activation providing new insight into the possible mechanisms mediating the effect of chronic stress on neuroinflammation
Title: Identification of Spinal Cord MicroRNA and Gene Signatures in a Model of Chronic Stress-Induced Visceral Hyperalgesia in Rat.
glycosylation of gp130 is essential for signal transduction of IL-6 family cytokines in cardiomyocytes
Title: The inhibition of N-glycosylation of glycoprotein 130 molecule abolishes STAT3 activation by IL-6 family cytokines in cultured cardiac myocytes.
In the chronic kidney disease-cardiac hypertrophy model exercise rescues cardiac disease via cardiotrophin-1/LIFR/gp 130/JAK/STAT3 pathway.
Title: Exercise rescued chronic kidney disease by attenuating cardiac hypertrophy through the cardiotrophin-1 -> LIFR/gp 130 -> JAK/STAT3 pathway.
Enhanced SOCS1 myocardial signalling is associated with accelerated transition from cardiac hypertrophy to heart failure via gp130/JAK1/STAT3 pathway.
Title: SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway.
Transplantation of mesenchymal stem cells promotes cell proliferation and organ repair, and activation of IL-6/gp130-mediated STAT3 signaling pathway via soluble IL-6 receptor is crucial in hepatic differentiation.
Title: Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration.
SHP2 negatively regulates alpha-SKA expression via RhoA inactivation and suggest that SHP2 implicates ERK5 in cardiomyocyte elongation downstream of gp130.
Title: SHP2 mediates gp130-dependent cardiomyocyte hypertrophy via negative regulation of skeletal alpha-actin gene.
Down-regulation of IL-6st and leptin receptor in glia by cytokines could potentially affect the disease course in MS.
Title: Cytokines decrease expression of interleukin-6 signal transducer and leptin receptor in central nervous system glia.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ciliary neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables ciliary neurotrophic factor receptor binding	IEA Inferred from Electronic Annotation more info
enables ciliary neurotrophic factor receptor binding	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to growth factor binding	ISO Inferred from Sequence Orthology more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-11 binding	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-11 receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-6 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-6 binding	IEA Inferred from Electronic Annotation more info
contributes_to interleukin-6 binding	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-6 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-6 receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to interleukin-6 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-6 receptor binding	IEA Inferred from Electronic Annotation more info
contributes_to interleukin-6 receptor binding	ISO Inferred from Sequence Orthology more info
enables leukemia inhibitory factor receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to leukemia inhibitory factor receptor activity	ISO Inferred from Sequence Orthology more info
enables oncostatin-M receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to oncostatin-M receptor activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ciliary neurotrophic factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in interleukin-11-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-11-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-27-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-27-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-6-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-6-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intestinal epithelial cell development	IEA Inferred from Electronic Annotation more info
involved_in intestinal epithelial cell development	ISO Inferred from Sequence Orthology more info
involved_in leukemia inhibitory factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in leukemia inhibitory factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in oncostatin-M-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in oncostatin-M-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info
involved_in triglyceride mobilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell body	ISO Inferred from Sequence Orthology more info
part_of ciliary neurotrophic factor receptor complex	IEA Inferred from Electronic Annotation more info
part_of ciliary neurotrophic factor receptor complex	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of interleukin-6 receptor complex	IEA Inferred from Electronic Annotation more info
part_of interleukin-6 receptor complex	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
is_active_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
part_of oncostatin-M receptor complex	IEA Inferred from Electronic Annotation more info
part_of oncostatin-M receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-6 receptor subunit beta

Names: IL-6 receptor subunit beta; IL-6R subunit beta; interleukin 6 signal transducer; membrane glycoprotein 130; oncostatin-M receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008725.3 → NP_001008725.2 interleukin-6 receptor subunit beta precursor

See identical proteins and their annotated locations for NP_001008725.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P40190

UniProtKB/TrEMBL

H9BFG4

Related

ENSRNOP00000090692.1, ENSRNOT00000109781.1

Conserved Domains (4) summary

smart00060
Location:518 → 598

FN3; Fibronectin type 3 domain

cd00063
Location:221 → 320

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:26 → 112

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:125 → 214

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

45798872..45839501

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231928.5 → XP_006231990.1 interleukin-6 receptor subunit beta isoform X1

See identical proteins and their annotated locations for XP_006231990.1

UniProtKB/TrEMBL

A0A8I5Y7Q5, A0A8I6AAL6, A6I5P1

Related

ENSRNOP00000077391.1

Conserved Domains (4) summary

smart00060
Location:534 → 614

FN3; Fibronectin type 3 domain

cd00063
Location:237 → 336

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:42 → 128

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:141 → 230

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_063281320.1 → XP_063137390.1 interleukin-6 receptor subunit beta isoform X1

UniProtKB/TrEMBL

A0A8I5Y7Q5, A6I5P1
XM_008760736.4 → XP_008758958.1 interleukin-6 receptor subunit beta isoform X1

See identical proteins and their annotated locations for XP_008758958.1

UniProtKB/TrEMBL

A0A8I5Y7Q5, A0A8I6AAL6, A6I5P1

Related

ENSRNOP00000083772.1

Conserved Domains (4) summary

smart00060
Location:534 → 614

FN3; Fibronectin type 3 domain

cd00063
Location:237 → 336

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:42 → 128

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:141 → 230

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039101766.2 → XP_038957694.1 interleukin-6 receptor subunit beta isoform X1

UniProtKB/TrEMBL

A0A8I5Y7Q5, A0A8I6AAL6, A6I5P1

Conserved Domains (4) summary

smart00060
Location:534 → 614

FN3; Fibronectin type 3 domain

cd00063
Location:237 → 336

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:42 → 128

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:141 → 230

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_039101767.2 → XP_038957695.1 interleukin-6 receptor subunit beta isoform X2

Conserved Domains (2) summary

smart00060
Location:187 → 267

FN3; Fibronectin type 3 domain

cd00063
Location:107 → 175

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...