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Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25116, updated on 23-Apr-2024

Summary

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Official Symbol
Hsd11b1provided by RGD
Official Full Name
hydroxysteroid 11-beta dehydrogenase 1provided by RGD
Primary source
RGD:2834
See related
Ensembl:ENSRNOG00000005861 AllianceGenome:RGD:2834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LRRGT00065
Summary
Enables NADP binding activity and steroid binding activity. Involved in several processes, including cellular response to estradiol stimulus; glucocorticoid metabolic process; and regulation of pentose-phosphate shunt. Located in apical part of cell; nuclear membrane; and rough endoplasmic reticulum. Used to study obesity. Biomarker of familial hyperlipidemia; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in cortisone reductase deficiency and cortisone reductase deficiency 2. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1885.5), Kidney (RPKM 1094.3) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q27
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (107277526..107327462, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (104728539..104798884, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (111946626..111996536, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 1 open reading frame 74 Neighboring gene TRAF3 interacting protein 3 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene G0/G1switch 2 Neighboring gene laminin subunit beta 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. High Sucrose Intake Ameliorates the Accumulation of Hepatic Triacylglycerol Promoted by Restraint Stress in Young Rats. Corona-Pérez A, et al. Lipids, 2015 Nov. PMID 26399510
  2. Activity of 11β-hydroxysteroid dehydrogenase in the adrenal glands, liver, and kidneys of rats with experimental diabetes. Cherkasova OP, et al. Bull Exp Biol Med, 2014 Dec. PMID 25430643
  3. Regulation of 11β-hydroxysteroid dehydrogenase type 1 and 7α-hydroxylase CYP7B1 during social stress. Vodička M, et al. PLoS One, 2014. PMID 24586766, Free PMC Article
  4. Distinct effect of stress on 11beta-hydroxysteroid dehydrogenase type 1 and corticosteroid receptors in dorsal and ventral hippocampus. Ergang P, et al. Physiol Res, 2014. PMID 24397806
  5. Effect of membrane solubilization on the inhibition of rat and hamster liver microsomal type I 11β-hydroxysteroid dehydrogenase by bile acids. Maeda Y, et al. Horm Metab Res, 2013 Nov. PMID 23979791

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11beta-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency.
    Title: Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11β-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency.
  2. The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety.
    Title: The Link between Activities of Hepatic 11beta-Hydroxysteroid Dehydrogenase-1 and Monoamine Oxidase-A in the Brain Following Repeated Predator Stress: Focus on Heightened Anxiety.
  3. Addressing the role of 11beta-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model.
    Title: Addressing the role of 11β-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model.
  4. These findings indicated that 11beta-HSD1 inhibition can give a potential benefit in reducing obesity and lowering insulin resistance by modulating the insulin-signaling pathway and adipocytokine production.
    Title: Inhibition of 11β-hydroxysteroid dehydrogenase type 1 ameliorates obesity-related insulin resistance.
  5. the high-sucrose intake in stressed rats (St + S30 group) reduced the hepatic 11beta-HSD-1 activity, the level of serum corticosterone, and the hepatic triacylglycerol content
    Title: High Sucrose Intake Ameliorates the Accumulation of Hepatic Triacylglycerol Promoted by Restraint Stress in Young Rats.
  6. the availability of H6PDH determines the different direction of 11beta-HSD1 in liver and Leydig cells.
    Title: Metabolic Coupling Determines the Activity: Comparison of 11β-Hydroxysteroid Dehydrogenase 1 and Its Coupling between Liver Parenchymal Cells and Testicular Leydig Cells.
  7. The enzyme activity increased 3-4 fold in the adrenal glands throughout the month-long development of alloxan diabetes.
    Title: Activity of 11β-hydroxysteroid dehydrogenase in the adrenal glands, liver, and kidneys of rats with experimental diabetes.
  8. Depending on the rat strain, stress stimulates 11HSD1 in the ventral hippocampus.
    Title: Distinct effect of stress on 11beta-hydroxysteroid dehydrogenase type 1 and corticosteroid receptors in dorsal and ventral hippocampus.
  9. the presented data clearly suggest a role of 11HSD1 in modulation of glucocorticoid feedback of the HPA axis during stress.
    Title: Regulation of 11β-hydroxysteroid dehydrogenase type 1 and 7α-hydroxylase CYP7B1 during social stress.
  10. The 11beta-HSDI enzymatic activity was measured using cortisone as a substrate.
    Title: Effect of membrane solubilization on the inhibition of rat and hamster liver microsomal type I 11β-hydroxysteroid dehydrogenase by bile acids.
Submit: New GeneRIF Correction See all GeneRIFs (54)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables 7-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADP binding ISO
Inferred from Sequence Orthology
more info
  
enables cortisol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables steroid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glucocorticoid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucocorticoid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
  
involved_in mineralocorticoid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of pentose-phosphate shunt IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in steroid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
11-beta-hydroxysteroid dehydrogenase 1
Names
11-DH
11-beta-HSD1
11-beta-hydroxysteroid dehydrogenase, type 1
11beta-HSD1
7-oxosteroid reductase
corticosteroid 11-beta-dehydrogenase isozyme 1
cortocosteroid 11-beta dehydrogenase
hydroxysteroid dehydrogenase, 11 beta type 1
NP_058776.2
XP_006250535.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429463.1 → NP_001416392.1  11-beta-hydroxysteroid dehydrogenase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  2. NM_001429464.1 → NP_001416393.1  11-beta-hydroxysteroid dehydrogenase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  3. NM_001429465.1 → NP_001416394.1  11-beta-hydroxysteroid dehydrogenase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  4. NM_017080.2 → NP_058776.2  11-beta-hydroxysteroid dehydrogenase 1 isoform 1

    See identical proteins and their annotated locations for NP_058776.2

    Status: VALIDATED

    Source sequence(s)
    BC078865, CK474613
    UniProtKB/Swiss-Prot
    O09170, P16232, Q6LDH6
    UniProtKB/TrEMBL
    A0A8I6GHA3, A6JH26
    Conserved Domains (1) summary
    cd05332
    Location:28 → 275
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    107277526..107327462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250473.5 → XP_006250535.1  11-beta-hydroxysteroid dehydrogenase 1 isoform X1

    See identical proteins and their annotated locations for XP_006250535.1

    UniProtKB/Swiss-Prot
    O09170, P16232, Q6LDH6
    UniProtKB/TrEMBL
    A0A8I6GHA3, A6JH26
    Conserved Domains (1) summary
    cd05332
    Location:28 → 275
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16232.2 GenPept UniProtKB/Swiss-Prot:P16232

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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