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Sstr1 somatostatin receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25033, updated on 11-Apr-2024

Summary

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Official Symbol
Sstr1provided by RGD
Official Full Name
somatostatin receptor 1provided by RGD
Primary source
RGD:3762
See related
Ensembl:ENSRNOG00000048145 AllianceGenome:RGD:3762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpcrrna
Summary
Enables somatostatin receptor activity. Involved in several processes, including brain development; cellular response to estradiol stimulus; and spermatogenesis. Located in cytoplasm and plasma membrane. Orthologous to human SSTR1 (somatostatin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 54.5) and Lung (RPKM 13.9) See more
Orthologs
human mouse all
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Genomic context

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Location:
6q23
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (81567237..81571759)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (75832292..75836806)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (79252914..79258611)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene lactate dehydrogenase A, pseudogene 17 Neighboring gene C-type lectin domain containing 14A Neighboring gene uncharacterized LOC134479390

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Agonist-induced endocytosis of rat somatostatin receptor 1. Roosterman D, et al. Endocrinology, 2007 Mar. PMID 17170097
  2. Activation of rat thymocytes selectively upregulates the expression of somatostatin receptor subtype-1. Sedqi M, et al. Biochem Mol Biol Int, 1996 Feb. PMID 8932524
  3. Cloning of a cDNA encoding a novel putative G-protein-coupled receptor expressed in specific rat brain regions. Meyerhof W, et al. DNA Cell Biol, 1991 Nov. PMID 1661599
  4. Cloning and expression of a rat somatostatin receptor enriched in brain. Li XJ, et al. J Biol Chem, 1992 Oct 25. PMID 1400442
  5. Upregulated expression of SSTR1 is involved in neuronal apoptosis and is coupled to the reduction of bcl-2 following intracerebral hemorrhage in adult rats. Yuan D, et al. Cell Mol Neurobiol, 2014 Oct. PMID 25035058

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In the jejunums of Cryptosporidium-parvum-infected rats, daily octreotide therapy decreased mRNA levels of SSTR1 on day 14 post-infection, although it increased mRNA levels of SSTR1 on day 50 post-infection. Specific SSTRs may regulate the inflammatory pathway in the rat intestinal inflammation model.
    Title: Octreotide modulates the expression of somatostatin receptor subtypes in inflamed rat jejunum induced by Cryptosporidium parvum.
  2. All SSTR1-5 proteins were observed at embryonal day 10 and increased with time in major structures, but the localization varied between the different subtypes. Only SSTR1 protein co-localized to a higher extent with the islet hormones studied.
    Title: Somatostatin receptor 1-5; expression profiles during rat development.
  3. up-regulated SSTR1 contributed to neuronal apoptosis after intracerebral hemorrhage, which was accompanied with reduced expression of bcl-2.
    Title: Upregulated expression of SSTR1 is involved in neuronal apoptosis and is coupled to the reduction of bcl-2 following intracerebral hemorrhage in adult rats.
  4. This study demonistrated that sstr1 and Melanin-concentrating hormone colization in neuron in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed throughout the brain.
    Title: Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons.
  5. Postsynaptic localization of sst(1) receptors and synaptic connectivity in the ARC undergo pronounced remodeling in parallel with the GH rhythm.
    Title: Subcellular dynamics of somatostatin receptor subtype 1 in the rat arcuate nucleus: receptor localization and synaptic connectivity vary in parallel with the ultradian rhythm of growth hormone secretion.
  6. The combined activation of SSTR1 and -2 shows a partial synergism as far as antiproliferative activity.
    Title: Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2.
  7. All five SSTR are expressed in splanchnic blood vessels. Cirrhosis reduces expression of SSTR1 in portal vein.
    Title: Expression of somatostatin receptors in splanchnic blood vessels of normal and cirrhotic rats.
  8. data suggest that higher expression of somatostatin receptor subtype 1 and 2 mRNA induced by the gsp oncogene may be a mechanism by which gsp-positive tumors show a greater response to somatostatin
    Title: Effect of gsp oncogene on somatostatin receptor subtype 1 and 2 mRNA levels in GHRH-responsive GH3 cells.
  9. Sstr1 mediates a dynamic process of endocytosis, recycling, and re-endocytosis of its cognate ligand.
    Title: Agonist-induced endocytosis of rat somatostatin receptor 1.
  10. the sequential activation of JAK2, SHP-2, and Src conveys the molecular signaling from SSTR1 to the activation of this phosphatase that is responsible for the final biological effects of SST
    Title: An intracellular multi-effector complex mediates somatostatin receptor 1 activation of phospho-tyrosine phosphatase eta.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables somatostatin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables somatostatin receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables somatostatin receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cellular response to estradiol stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in forebrain development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in somatostatin signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somatostatin signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of G protein-coupled receptor heterodimeric complex ISO
Inferred from Sequence Orthology
more info
  
part_of G protein-coupled receptor homodimeric complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
somatostatin receptor type 1
Names
RNGPCRRNA
SRIF-2
SS-1-R
SS1-R
SS1R
Somatostatin receptor subtype 1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012719.2 → NP_036851.1  somatostatin receptor type 1

    See identical proteins and their annotated locations for NP_036851.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    P28646
    UniProtKB/TrEMBL
    A6HBQ4, Q7TT86
    Related
    ENSRNOP00000067355.1, ENSRNOT00000073970.3
    Conserved Domains (2) summary
    pfam00001
    Location:75 → 323
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:67 → 189
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    81567237..81571759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240115.4 → XP_006240177.1  somatostatin receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_006240177.1

    UniProtKB/Swiss-Prot
    P28646
    UniProtKB/TrEMBL
    A6HBQ4, Q7TT86
    Conserved Domains (2) summary
    pfam00001
    Location:75 → 323
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:67 → 189
    7tm_4; Olfactory receptor

  2. XM_063261554.1 → XP_063117624.1  somatostatin receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P28646
    UniProtKB/TrEMBL
    A6HBQ4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28646.1 GenPept UniProtKB/Swiss-Prot:P28646

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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