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Trpv3 transient receptor potential cation channel, subfamily V, member 3 [ Mus musculus (house mouse) ]

Gene ID: 246788, updated on 11-Apr-2024

Summary

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Official Symbol
Trpv3provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily V, member 3provided by MGI
Primary source
MGI:MGI:2181407
See related
Ensembl:ENSMUSG00000043029 AllianceGenome:MGI:2181407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nh; VRL3; 1110036I10Rik
Summary
Enables cation channel activity. Acts upstream of or within response to temperature stimulus. Located in membrane. Is expressed in central nervous system and sensory organ. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in colorectal cancer; congenital stationary night blindness; keratosis (multiple); migraine with aura; and schizophrenia. Orthologous to human TRPV3 (transient receptor potential cation channel subfamily V member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 2.4), large intestine adult (RPKM 0.4) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B4; 11 45.25 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (73158315..73191194)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73267489..73300368)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene transient receptor potential cation channel, subfamily V, member 1 Neighboring gene STARR-seq mESC enhancer starr_29931 Neighboring gene STARR-seq mESC enhancer starr_29933 Neighboring gene STARR-seq mESC enhancer starr_29936 Neighboring gene aspartoacylase Neighboring gene spermatogenesis associated 22 Neighboring gene olfactory receptor family 1 subfamily E member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nadezhdin KD, et al. Nat Struct Mol Biol, 2021 Jul. PMID 34239124, Free PMC Article
  2. Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine. Liu Q, et al. Elife, 2021 Apr 20. PMID 33876725, Free PMC Article
  3. TRPV3 endogenously expressed in murine colonic epithelial cells is inhibited by the novel TRPV3 blocker 26E01. Bischof M, et al. Cell Calcium, 2020 Dec. PMID 33161279
  4. The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism. Shimada H, et al. Nat Struct Mol Biol, 2020 Jul. PMID 32572254
  5. Transient Receptor Potential Cation Channel Subfamily Vanilloid 4 and 3 in the Inner Ear Protect Hearing in Mice. Wang S, et al. Front Mol Neurosci, 2019. PMID 31866822, Free PMC Article

See all (91) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Whole genome sequencing analysis of alpaca suggests TRPV3 as a candidate gene for the suri phenotype.
    Title: Whole genome sequencing analysis of alpaca suggests TRPV3 as a candidate gene for the suri phenotype.
  2. Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice.
    Title: Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice.
  3. TRPV3 and Itch: The Role of TRPV3 in Chronic Pruritus according to Clinical and Experimental Evidence.
    Title: TRPV3 and Itch: The Role of TRPV3 in Chronic Pruritus according to Clinical and Experimental Evidence.
  4. Coassembly of Warm Temperature-Sensitive Transient Receptor Potential Vanilloid (TRPV) 3 and TRPV4 Channel Complexes with Distinct Functional Properties.
    Title: Coassembly of Warm Temperature-Sensitive Transient Receptor Potential Vanilloid (TRPV) 3 and TRPV4 Channel Complexes with Distinct Functional Properties.
  5. TRPV3 enhances skin keratinocyte proliferation through EGFR-dependent signaling pathways.
    Title: TRPV3 enhances skin keratinocyte proliferation through EGFR-dependent signaling pathways.
  6. Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes.
    Title: Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes.
  7. TRPV3 endogenously expressed in murine colonic epithelial cells is inhibited by the novel TRPV3 blocker 26E01.
    Title: TRPV3 endogenously expressed in murine colonic epithelial cells is inhibited by the novel TRPV3 blocker 26E01.
  8. Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.
    Title: Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.
  9. Deletion of TRPV3 and CaV3.2 T-type channels in mice undermines fertility and Ca2+ homeostasis in oocytes and eggs.
    Title: Deletion of TRPV3 and CaV3.2 T-type channels in mice undermines fertility and Ca2+ homeostasis in oocytes and eggs.
  10. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes.
    Title: PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC124324, MGC124325

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of hair cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to temperature stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
transient receptor potential cation channel subfamily V member 3
Names
TRP ion channel TRPV3
non-hair

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371006.1 → NP_001357935.1  transient receptor potential cation channel subfamily V member 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645739, AL663116
    UniProtKB/TrEMBL
    Q32MT9
    Conserved Domains (2) summary
    TIGR00870
    Location:123 → 769
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:214 → 245
    ANK; ANK repeat [structural motif]

  2. NM_145099.3 → NP_659567.2  transient receptor potential cation channel subfamily V member 3 isoform 1

    See identical proteins and their annotated locations for NP_659567.2

    Status: VALIDATED

    Source sequence(s)
    AL645739, AL663116
    Consensus CDS
    CCDS25004.1
    UniProtKB/Swiss-Prot
    Q5SV08, Q8K424
    UniProtKB/TrEMBL
    Q32MT9
    Related
    ENSMUSP00000053755.3, ENSMUST00000049676.3
    Conserved Domains (2) summary
    TIGR00870
    Location:123 → 753
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:214 → 245
    ANK; ANK repeat [structural motif]

RNA

  1. NR_163834.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL645739, AL663116

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    73158315..73191194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533348.3 → XP_006533411.1  transient receptor potential cation channel subfamily V member 3 isoform X1

    Conserved Domains (2) summary
    TIGR00870
    Location:123 → 517
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:214 → 245
    ANK; ANK repeat [structural motif]

RNA

  1. XR_004936963.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K424.2 GenPept UniProtKB/Swiss-Prot:Q8K424

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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