Il27 interleukin 27 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il27provided by MGI
Official Full Name: interleukin 27provided by MGI
Primary source: MGI:MGI:2384409
See related: Ensembl:ENSMUSG00000044701 AllianceGenome:MGI:2384409
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p28; Il30; IL-27; IL27-A; IL-27-A; IL-27p28
Summary: Enables interleukin-27 receptor binding activity. Acts upstream of or within positive regulation of defense response to virus by host and regulation of T cell proliferation. Located in extracellular space. Is expressed in decidua; embryo; and extraembryonic component. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and pulmonary tuberculosis. Orthologous to human IL27 (interleukin 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in genital fat pad adult (RPKM 5.8), spleen adult (RPKM 2.5) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 69.18 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (126188181..126194197, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (126589009..126595035, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endogenous IL-27 during toxoplasmosis limits early monocyte responses and their inflammatory activation by pathological T cells.
Title: Endogenous IL-27 during toxoplasmosis limits early monocyte responses and their inflammatory activation by pathological T cells.
IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model.
Title: IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model.
Deletion of IL-27p28 induces CD8 T cell immunity against colorectal tumorigenesis.
Title: Deletion of IL-27p28 induces CD8 T cell immunity against colorectal tumorigenesis.
IL-27p28 specifically regulates MHC II expression in macrophages through CIITA.
Title: IL-27p28 specifically regulates MHC II expression in macrophages through CIITA.
IL-27 produced during acute malaria infection regulates Plasmodium-specific memory CD4[+] T cells.
Title: IL-27 produced during acute malaria infection regulates Plasmodium-specific memory CD4(+) T cells.
Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity.
Title: Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of T(H)17 cell immunity.
IL-27 regulates NLRP3 inflammasome activation of MDSCs in experimental Sjogren's syndrome.
Title: IL-27 regulates NLRP3 inflammasome activation of MDSCs in experimental Sjögren's syndrome.
IL-27 increases energy storage in white adipocytes by enhancing glucose uptake and fatty acid esterification.
Title: IL-27 increases energy storage in white adipocytes by enhancing glucose uptake and fatty acid esterification.
Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia.
Title: Interleukin-27 potentiates CD8+ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia.
IL-27p28 knockout aggravates Doxorubicin-induced cardiotoxicity by regulating Macrophage polarization.
Title: IL-27p28 knockout aggravates Doxorubicin-induced cardiotoxicity by regulating Macrophage polarization.

Submit: New GeneRIF Correction See all GeneRIFs (201)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (3) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235779

NoName (e-PCR)
- UniSTS:491588

Ebi3 (e-PCR), detects polymorphism
- UniSTS:532616

Il27 (e-PCR), detects polymorphism
- UniSTS:532619

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables interleukin-27 receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-27 receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of defense response to virus by host	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of T-helper 1 cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of T-helper 1 cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: interleukin-27 subunit alpha

Names: IL-27 p28 subunit; IL-27 subunit alpha; interleukin 30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.