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Dnajc28 DnaJ heat shock protein family (Hsp40) member C28 [ Mus musculus (house mouse) ]

Gene ID: 246738, updated on 5-Mar-2024

Summary

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Official Symbol
Dnajc28provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C28provided by MGI
Primary source
MGI:MGI:2181053
See related
Ensembl:ENSMUSG00000039763 AllianceGenome:MGI:2181053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORF28
Summary
Predicted to be involved in Golgi organization; Golgi vesicle prefusion complex stabilization; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be part of Golgi transport complex. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and respiratory system. Orthologous to human DNAJC28 (DnaJ heat shock protein family (Hsp40) member C28). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 4.0), testis adult (RPKM 2.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Dnajc28 in Genome Data Viewer
Location:
16 C3.3; 16 53.17 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91411142..91415931, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91614257..91618999, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41480 Neighboring gene interferon gamma receptor 2 Neighboring gene transmembrane protein 50B Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:91588013-91588235 Neighboring gene STARR-positive B cell enhancer ABC_E3173 Neighboring gene STARR-positive B cell enhancer mm9_chr16:91619128-91619428 Neighboring gene phosphoribosylglycinamide formyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E3174 Neighboring gene STARR-positive B cell enhancer ABC_E7475 Neighboring gene predicted gene, 36712 Neighboring gene Son DNA binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC27620

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 28
Names
DnaJ (Hsp40) homolog, subfamily C, member 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099738.1 → NP_001093208.1  dnaJ homolog subfamily C member 28 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC131691, AK081175, AV328433, BB535506, BB622009, BU520154
    Consensus CDS
    CCDS49912.1
    UniProtKB/TrEMBL
    E9Q1L7
    Related
    ENSMUSP00000132288.2, ENSMUST00000169982.2
    Conserved Domains (3) summary
    PLN03085
    Location:224 → 362
    PLN03085; nucleobase:cation symporter-1; Provisional
    pfam00226
    Location:72 → 132
    DnaJ; DnaJ domain
    pfam09350
    Location:227 → 295
    DUF1992; Domain of unknown function (DUF1992)

  2. NM_138664.2 → NP_619605.2  dnaJ homolog subfamily C member 28 isoform 2

    See identical proteins and their annotated locations for NP_619605.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream AUG, compared to variant 1. The resulting protein (isoform 2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC131691, AK081175, AV328433, BB535506, BB622009
    Consensus CDS
    CCDS49911.1
    UniProtKB/Swiss-Prot
    Q8VCE1, Q99JX0
    UniProtKB/TrEMBL
    Q8C4S9
    Related
    ENSMUSP00000048113.9, ENSMUST00000049244.10
    Conserved Domains (4) summary
    PLN03085
    Location:200 → 338
    PLN03085; nucleobase:cation symporter-1; Provisional
    COG2214
    Location:45 → 187
    CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
    pfam00226
    Location:48 → 108
    DnaJ; DnaJ domain
    pfam09350
    Location:203 → 271
    DUF1992; Domain of unknown function (DUF1992)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    91411142..91415931 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159930.1 → XP_036015823.1  dnaJ homolog subfamily C member 28 isoform X1

    UniProtKB/Swiss-Prot
    Q8VCE1, Q99JX0
    UniProtKB/TrEMBL
    Q8C4S9
    Conserved Domains (4) summary
    PLN03085
    Location:200 → 338
    PLN03085; nucleobase:cation symporter-1; Provisional
    COG2214
    Location:45 → 187
    CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
    pfam00226
    Location:48 → 108
    DnaJ; DnaJ domain
    pfam09350
    Location:203 → 271
    DUF1992; Domain of unknown function (DUF1992)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCE1.2 GenPept UniProtKB/Swiss-Prot:Q8VCE1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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