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Oas1a 2'-5' oligoadenylate synthetase 1A [ Mus musculus (house mouse) ]

Gene ID: 246730, updated on 3-Apr-2024

Summary

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Official Symbol
Oas1aprovided by MGI
Official Full Name
2'-5' oligoadenylate synthetase 1Aprovided by MGI
Primary source
MGI:MGI:2180860
See related
Ensembl:ENSMUSG00000052776 AllianceGenome:MGI:2180860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L3
Summary
Enables 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Involved in purine nucleotide biosynthetic process. Acts upstream of or within negative regulation of viral process. Predicted to be located in mitochondrion; nucleus; and ribosome. Predicted to be active in cytosol; membrane; and nucleoplasm. Predicted to colocalize with cytoplasm. Is expressed in appendicular skeleton; axial skeleton; lower jaw; and testis. Orthologous to human OAS1 (2'-5'-oligoadenylate synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 22.5), colon adult (RPKM 20.5) and 18 other tissues See more
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Genomic context

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Location:
5 F; 5 60.65 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121034319..121045588, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120896256..120907544, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase 1H Neighboring gene STARR-seq mESC enhancer starr_14254 Neighboring gene 2'-5' oligoadenylate synthetase 1G Neighboring gene 2'-5' oligoadenylate synthetase 1 pseudogene Neighboring gene 2'-5' oligoadenylate synthetase 1D Neighboring gene rabphilin 3A Neighboring gene predicted gene, 32185

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse 2-5A synthetase cDNA: nucleotide sequence and comparison to human 2-5A synthetase. Ichii Y, et al. Nucleic Acids Res, 1986 Dec 22. PMID 3808949, Free PMC Article
  2. A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication. Coccia EM, et al. Virology, 1990 Nov. PMID 2171206
  3. Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon. Birdwell LD, et al. J Virol, 2016 Jan 6. PMID 26739051, Free PMC Article
  4. Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology. Zhao L, et al. Cell Host Microbe, 2012 Jun 14. PMID 22704621, Free PMC Article
  5. The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells. Elbahesh H, et al. Virology, 2011 Jan 20. PMID 21056894, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thus, activation of RNase L does not require mouse hepatitis virus virus-induced interferon but rather correlates with adequate levels of basal Oas gene expression, maintained by basal interferon signaling.
    Title: Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.
  2. Mouse hepatitis virus Ns2 cleaves 2',5'-oligoadenylate, the product of 2',5'-oligoadenylate synthetase, to prevent activation of the cellular endoribonuclease RNase L and consequently block viral RNA degradation.
    Title: Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology.
  3. Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2
    Title: Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation.
  4. In the absence of a functional OAS1a pathway, herpes simplex virus type 1 antigen expression is more widespread, and the ability of IFN-beta transgene treatment to reduce infectious HSV-1 in eyes and trigeminal ganglia is lost.
    Title: Critical role for the oligoadenylate synthetase/RNase L pathway in response to IFN-beta during acute ocular herpes simplex virus type 1 infection.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2'-5'-oligoadenylate synthetase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2'-5'-oligoadenylate synthetase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2'-5'-oligoadenylate synthetase activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of IP-10 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of viral process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cellular respiration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus TAS
Traceable Author Statement
more info
 PubMed 
involved_in surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in ribosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
2'-5'-oligoadenylate synthase 1A
Names
(2-5')oligo(A) synthase 1A
(2-5')oligo(A) synthetase 1A
2-5A synthase 1A
2-5A synthetase 1A
p42 OAS
NP_001411632.1
NP_001411633.1
NP_001411634.1
NP_001411635.1
NP_001411636.1
NP_001411637.1
NP_001411638.1
NP_001411639.1
NP_001411640.1
NP_660212.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424703.1 → NP_001411632.1  2'-5'-oligoadenylate synthase 1A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC015535

  2. NM_001424704.1 → NP_001411633.1  2'-5'-oligoadenylate synthase 1A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC015535

  3. NM_001424705.1 → NP_001411634.1  2'-5'-oligoadenylate synthase 1A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC015535

  4. NM_001424706.1 → NP_001411635.1  2'-5'-oligoadenylate synthase 1A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC015535

  5. NM_001424707.1 → NP_001411636.1  2'-5'-oligoadenylate synthase 1A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC015535

  6. NM_001424708.1 → NP_001411637.1  2'-5'-oligoadenylate synthase 1A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC015535

  7. NM_001424709.1 → NP_001411638.1  2'-5'-oligoadenylate synthase 1A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC015535

  8. NM_001424710.1 → NP_001411639.1  2'-5'-oligoadenylate synthase 1A isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC015535

  9. NM_001424711.1 → NP_001411640.1  2'-5'-oligoadenylate synthase 1A isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC015535

  10. NM_145211.2 → NP_660212.2  2'-5'-oligoadenylate synthase 1A isoform 1

    See identical proteins and their annotated locations for NP_660212.2

    Status: VALIDATED

    Source sequence(s)
    AC015535, AK149613, BU699042
    Consensus CDS
    CCDS19630.1
    UniProtKB/Swiss-Prot
    F2Z419, P11928, Q3UEC1, Q64440, Q91VI0
    UniProtKB/TrEMBL
    Q8VEH7
    Related
    ENSMUSP00000079198.8, ENSMUST00000080322.8
    Conserved Domains (2) summary
    cd05400
    Location:29 → 212
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    pfam10421
    Location:164 → 348
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

RNA

  1. NR_188861.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015535

  2. NR_188862.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015535

  3. NR_188863.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC015535

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    121034319..121045588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11928.2 GenPept UniProtKB/Swiss-Prot:P11928

Gene LinkOut

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