U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CDC26 cell division cycle 26 [ Homo sapiens (human) ]

Gene ID: 246184, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
CDC26provided by HGNC
Official Full Name
cell division cycle 26provided by HGNC
Primary source
HGNC:HGNC:17839
See related
Ensembl:ENSG00000176386 MIM:614533; AllianceGenome:HGNC:17839
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC12; ANAPC12; C9orf17
Summary
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 9.9), appendix (RPKM 9.9) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CDC26 in Genome Data Viewer
Location:
9q32
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (113266992..113275572, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (125465832..125474426, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116029272..116037852, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 31 member 2 Neighboring gene FKBP prolyl isomerase family member 15 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:115949815-115951014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28835 Neighboring gene solute carrier family 31 member 1 Neighboring gene uncharacterized LOC107987119 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:116036963-116037818 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_106320 Neighboring gene pre-mRNA splicing tri-snRNP complex factor PRPF4 Neighboring gene ring finger protein 183

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure. Wang J, et al. Nat Struct Mol Biol, 2009 Sep. PMID 19668213, Free PMC Article
  2. Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Zachariae W, et al. Science, 1996 Nov 15. PMID 8895471
  3. A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia. Wu H, et al. Clin Genet, 2022 Jan. PMID 34595750
  4. LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C. Masuda K, et al. PLoS One, 2015. PMID 25723520, Free PMC Article
  5. The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. Lim HJ, et al. Mol Cell Biol, 2013 Nov. PMID 23979597, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of meiotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of anaphase-promoting complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of anaphase-promoting complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

Go to the top of the page Help
Preferred Names
anaphase-promoting complex subunit CDC26
Names
CDC26 subunit of anaphase promoting complex
anaphase-promoting complex subunit 12
cell division cycle 26 homolog
cell division cycle protein 26 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139286.4 → NP_644815.1  anaphase-promoting complex subunit CDC26

    See identical proteins and their annotated locations for NP_644815.1

    Status: REVIEWED

    Source sequence(s)
    AL449305, BC042534, BF244254, CA446805
    Consensus CDS
    CCDS6790.1
    UniProtKB/Swiss-Prot
    Q8NHZ8
    Related
    ENSP00000363322.3, ENST00000374206.4
    Conserved Domains (1) summary
    pfam10471
    Location:1 → 34
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    113266992..113275572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014575.2 → XP_016870064.1  anaphase-promoting complex subunit CDC26 isoform X1

    UniProtKB/Swiss-Prot
    Q8NHZ8
    Conserved Domains (1) summary
    pfam10471
    Location:1 → 34
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

  2. XM_047423145.1 → XP_047279101.1  anaphase-promoting complex subunit CDC26 isoform X1

    UniProtKB/Swiss-Prot
    Q8NHZ8

  3. XM_017014573.2 → XP_016870062.1  anaphase-promoting complex subunit CDC26 isoform X1

    UniProtKB/Swiss-Prot
    Q8NHZ8
    Conserved Domains (1) summary
    pfam10471
    Location:1 → 34
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

  4. XM_047423146.1 → XP_047279102.1  anaphase-promoting complex subunit CDC26 isoform X1

    UniProtKB/Swiss-Prot
    Q8NHZ8

  5. XM_047423144.1 → XP_047279100.1  anaphase-promoting complex subunit CDC26 isoform X1

    UniProtKB/Swiss-Prot
    Q8NHZ8

  6. XM_017014574.2 → XP_016870063.1  anaphase-promoting complex subunit CDC26 isoform X1

    UniProtKB/Swiss-Prot
    Q8NHZ8
    Conserved Domains (1) summary
    pfam10471
    Location:1 → 34
    ANAPC_CDC26; Anaphase-promoting complex APC subunit CDC26

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    125465832..125474426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362600.1 → XP_054218575.1  anaphase-promoting complex subunit CDC26 isoform X1

    UniProtKB/Swiss-Prot
    Q8NHZ8

  2. XM_054362602.1 → XP_054218577.1  anaphase-promoting complex subunit CDC26 isoform X1

    UniProtKB/Swiss-Prot
    Q8NHZ8

  3. XM_054362601.1 → XP_054218576.1  anaphase-promoting complex subunit CDC26 isoform X1

    UniProtKB/Swiss-Prot
    Q8NHZ8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NHZ8.1 GenPept UniProtKB/Swiss-Prot:Q8NHZ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous