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Slc36a2 solute carrier family 36 (proton/amino acid symporter), member 2 [ Mus musculus (house mouse) ]

Gene ID: 246049, updated on 30-Apr-2024

Summary

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Official Symbol
Slc36a2provided by MGI
Official Full Name
solute carrier family 36 (proton/amino acid symporter), member 2provided by MGI
Primary source
MGI:MGI:1891430
See related
Ensembl:ENSMUSG00000020264 AllianceGenome:MGI:1891430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAT2; Tramd1; A530067G19Rik
Summary
Enables amino acid transmembrane transporter activity. Acts upstream of or within neutral amino acid transport and proton transmembrane transport. Located in plasma membrane. Is expressed in several structures, including ear; face; heart; nervous system; and skeleton. Human ortholog(s) of this gene implicated in iminoglycinuria. Orthologous to human SLC36A2 (solute carrier family 36 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 166.7), subcutaneous fat pad adult (RPKM 116.6) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 32.16 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55049294..55075924, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (55158468..55185099, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6987 Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 3, opposite strand Neighboring gene predicted gene, 31688 Neighboring gene STARR-positive B cell enhancer ABC_E3952 Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 1, opposite strand Neighboring gene STARR-positive B cell enhancer mm9_chr11:55017598-55017899 Neighboring gene solute carrier family 36 (proton/amino acid symporter), member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transport of L-proline by the proton-coupled amino acid transporter PAT2 in differentiated 3T3-L1 cells. Zebisch K, et al. Amino Acids, 2013 Feb. PMID 22711289
  2. Association of PAT proteins with lipid storage droplets in term fetal membranes. Ackerman WE 4th, et al. Placenta, 2007 May-Jun. PMID 16965813
  3. Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2. Foltz M, et al. Eur J Biochem, 2004 Aug. PMID 15291811
  4. The proton/amino acid cotransporter PAT2 is expressed in neurons with a different subcellular localization than its paralog PAT1. Rubio-Aliaga I, et al. J Biol Chem, 2004 Jan 23. PMID 14600155
  5. A cluster of proton/amino acid transporter genes in the human and mouse genomes. Boll M, et al. Genomics, 2003 Jul. PMID 12809675

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The amino acid transporter PAT2 and the purinergic receptor P2RX5 are cell surface markers expressed in classical brown and beige adipocytes.
    Title: ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.
  2. During the 14 day differentiation period the uptake of the prototype PAT2 substrate L-[(3)H]proline increased ~5-fold.
    Title: Transport of L-proline by the proton-coupled amino acid transporter PAT2 in differentiated 3T3-L1 cells.
  3. proton binding affinity to PAT2 is substrate-independent, favouring a sequential binding of proton followed by substrate
    Title: Substrate specificity and transport mode of the proton-dependent amino acid transporter mPAT2.
  4. Classification of lipid storage droplets based on this protein suggests that these organelles may serve specialized functions within individual cells.
    Title: Association of PAT proteins with lipid storage droplets in term fetal membranes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-alanine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-alanine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-proline transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-proline transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables L-tyrosine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amino acid:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amino acid:proton symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables glycine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables proline:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables proline:proton symporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-alanine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within L-alanine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid export across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in glycine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of glycine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in proline transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proline transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proline transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proton transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of proline transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proton transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
proton-coupled amino acid transporter 2
Names
proton/amino acid transporter 2
solute carrier family 36 member 2
tramdorin 1 (transmembrane domain rich protein)
tramdorin-1
transmembrane domain rich protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153170.3 → NP_694810.2  proton-coupled amino acid transporter 2

    See identical proteins and their annotated locations for NP_694810.2

    Status: VALIDATED

    Source sequence(s)
    AK079053, AK086373, BB520081
    Consensus CDS
    CCDS24709.1
    UniProtKB/Swiss-Prot
    Q8BHK3, Q8BUB0, Q8JZP1
    Related
    ENSMUSP00000045613.6, ENSMUST00000039305.6
    Conserved Domains (1) summary
    cl00456
    Location:48 → 458
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    55049294..55075924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533324.5 → XP_006533387.1  proton-coupled amino acid transporter 2 isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:48 → 426
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_006533325.5 → XP_006533388.1  proton-coupled amino acid transporter 2 isoform X3

    Conserved Domains (1) summary
    cl00456
    Location:7 → 321
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_030246005.2 → XP_030101865.1  proton-coupled amino acid transporter 2 isoform X2

    Conserved Domains (1) summary
    cl00456
    Location:1 → 396
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHK3.1 GenPept UniProtKB/Swiss-Prot:Q8BHK3

Gene LinkOut

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