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Pcmtd2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 245867, updated on 11-Apr-2024

Summary

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Official Symbol
Pcmtd2provided by MGI
Official Full Name
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2provided by MGI
Primary source
MGI:MGI:1923927
See related
Ensembl:ENSMUSG00000027589 AllianceGenome:MGI:1923927
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5330414D10Rik
Summary
Predicted to enable protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Predicted to be involved in cellular protein modification process. Predicted to be active in cytoplasm. Is expressed in cerebellum and retina outer nuclear layer. Orthologous to human PCMTD2 (protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 6.1), frontal lobe adult (RPKM 5.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H4; 2 103.81 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181471952..181499253)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181830159..181857460)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene neuropeptides B/W receptor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06758 Neighboring gene myelin transcription factor 1 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr2:181598872-181599172 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide K Neighboring gene poly(A) binding protein, cytoplasmic 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
  2. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36470

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein-L-isoaspartate O-methyltransferase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291211.1 → NP_001278140.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AL845173, BC031360, BY477720, CD774000, CJ149855
    Consensus CDS
    CCDS71224.1
    UniProtKB/TrEMBL
    B0R0C7, Q6I682
    Related
    ENSMUSP00000104385.2, ENSMUST00000108754.8
    Conserved Domains (3) summary
    pfam01135
    Location:11 → 214
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
    pfam12847
    Location:80 → 189
    Methyltransf_18; Methyltransferase domain
    cl17173
    Location:7 → 126
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. NM_153594.3 → NP_705822.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_705822.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL845173, BC031360, BY477720, CD774000, CJ149855
    Consensus CDS
    CCDS17224.1
    UniProtKB/Swiss-Prot
    Q3UKB7, Q8BHD8, Q8BJT6, Q8BK38, Q8C0H6, Q8R1D5
    Related
    ENSMUSP00000029116.8, ENSMUST00000029116.14
    Conserved Domains (1) summary
    pfam01135
    Location:11 → 219
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    181471952..181499253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500620.4 → XP_006500683.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006500683.1

    Conserved Domains (1) summary
    pfam01135
    Location:11 → 214
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

  2. XM_006500626.4 → XP_006500689.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X4

    Conserved Domains (1) summary
    pfam01135
    Location:11 → 220
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

  3. XM_006500622.4 → XP_006500685.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    pfam01135
    Location:11 → 220
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

  4. XM_006500621.4 → XP_006500684.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006500684.1

    Conserved Domains (1) summary
    pfam01135
    Location:11 → 214
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

  5. XM_036162057.1 → XP_036017950.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q3UKB7, Q8BHD8, Q8BJT6, Q8BK38, Q8C0H6, Q8R1D5
    Conserved Domains (1) summary
    pfam01135
    Location:11 → 219
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

  6. XM_036162056.1 → XP_036017949.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    pfam01135
    Location:11 → 214
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

RNA

  1. XR_004940357.1 RNA Sequence

  2. XR_004940358.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHD8.1 GenPept UniProtKB/Swiss-Prot:Q8BHD8

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