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Ssh3 slingshot protein phosphatase 3 [ Mus musculus (house mouse) ]

Gene ID: 245857, updated on 11-Apr-2024

Summary

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Official Symbol
Ssh3provided by MGI
Official Full Name
slingshot protein phosphatase 3provided by MGI
Primary source
MGI:MGI:2683546
See related
Ensembl:ENSMUSG00000034616 AllianceGenome:MGI:2683546
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SSH-3; SSH-3L
Summary
Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in actin cytoskeleton organization and negative regulation of actin filament polymerization. Predicted to be located in cytoskeleton and nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and skin. Orthologous to human SSH3 (slingshot protein phosphatase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 50.6), large intestine adult (RPKM 32.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 3.96 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4311696..4319261, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4261668..4269233, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1500032F14 gene Neighboring gene STARR-positive B cell enhancer ABC_E11667 Neighboring gene predicted gene, 45928 Neighboring gene cardiotrophin-like cytokine factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E969 Neighboring gene polymerase (DNA-directed), delta 4 Neighboring gene STARR-positive B cell enhancer ABC_E5676 Neighboring gene microRNA 6985 Neighboring gene ankyrin repeat domain 13 family, member D Neighboring gene STARR-positive B cell enhancer ABC_E5677 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4294334-4294632 Neighboring gene G protein-coupled receptor kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E7626 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4302085-4302194 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4302330-4302483 Neighboring gene STARR-positive B cell enhancer ABC_E9988

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Slingshot-3 dephosphorylates ADF/cofilin but is dispensable for mouse development. Kousaka K, et al. Genesis, 2008 May. PMID 18442045
  2. Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. Ohta Y, et al. Genes Cells, 2003 Oct. PMID 14531860
  3. Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. Scekic-Zahirovic J, et al. EMBO J, 2016 May 17. PMID 26951610, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase Slingshot homolog 3
Names
SSH-like protein 3
slingshot homolog 3
slingshot-3L
slingshot-like 3
NP_001343549.1
NP_001361616.1
NP_932781.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356620.1 → NP_001343549.1  protein phosphatase Slingshot homolog 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC140073
    Consensus CDS
    CCDS89300.1
    UniProtKB/TrEMBL
    A0A498WGL8
    Related
    ENSMUSP00000109483.6, ENSMUST00000113852.6
    Conserved Domains (3) summary
    cd11652
    Location:3 → 255
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:325 → 460
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:268 → 319
    DEK_C; DEK C terminal domain

  2. NM_001374687.1 → NP_001361616.1  protein phosphatase Slingshot homolog 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AB099289, AC140073, AK149880
    Related
    ENSMUSP00000158486.2, ENSMUST00000236794.2
    Conserved Domains (3) summary
    cd11652
    Location:3 → 256
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd14571
    Location:327 → 470
    DSP_slingshot_3; dual specificity phosphatase domain of slingshot homolog 3
    pfam08766
    Location:273 → 324
    DEK_C; DEK C terminal domain

  3. NM_198113.3 → NP_932781.1  protein phosphatase Slingshot homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_932781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1)
    Source sequence(s)
    AC140073, AK148293, AK164662, AW060821, BE864347
    Consensus CDS
    CCDS29425.1
    UniProtKB/Swiss-Prot
    Q3UDX0, Q8K330
    Related
    ENSMUSP00000047718.9, ENSMUST00000037992.16
    Conserved Domains (3) summary
    cd11652
    Location:3 → 256
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:326 → 461
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:269 → 317
    DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4311696..4319261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K330.1 GenPept UniProtKB/Swiss-Prot:Q8K330

Gene LinkOut

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