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Rragb Ras-related GTP binding B [ Mus musculus (house mouse) ]

Gene ID: 245670, updated on 18-Apr-2024

Summary

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Official Symbol
Rragbprovided by MGI
Official Full Name
Ras-related GTP binding Bprovided by MGI
Primary source
MGI:MGI:3038613
See related
Ensembl:ENSMUSG00000041658 AllianceGenome:MGI:3038613
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GTP binding activity; GTPase activity; and GTPase binding activity. Predicted to be involved in several processes, including cellular response to amino acid stimulus; cellular response to leucine starvation; and positive regulation of TORC1 signaling. Predicted to be located in cytoplasm. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Orthologous to human RRAGB (Ras related GTP binding B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 18.2), cerebellum adult (RPKM 16.5) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X F3; X 68.46 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (151920640..151973188)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (153137644..153190192)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 5396 Neighboring gene forkhead box R2 Neighboring gene STARR-seq mESC enhancer starr_48111 Neighboring gene STARR-seq mESC enhancer starr_48113 Neighboring gene STARR-seq mESC enhancer starr_48114 Neighboring gene STARR-seq mESC enhancer starr_48116 Neighboring gene Kruppel-like transcription factor 8 Neighboring gene STARR-seq mESC enhancer starr_48117 Neighboring gene STARR-seq mESC enhancer starr_48118 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance. Do MH, et al. J Exp Med, 2020 Jan 6. PMID 31649036, Free PMC Article
  2. Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Jewell JL, et al. Science, 2015 Jan 9. PMID 25567907, Free PMC Article
  3. Rag GTPases are cardioprotective by regulating lysosomal function. Kim YC, et al. Nat Commun, 2014 Jul 1. PMID 24980141, Free PMC Article
  4. RagA, but not RagB, is essential for embryonic development and adult mice. Efeyan A, et al. Dev Cell, 2014 May 12. PMID 24768164, Free PMC Article
  5. YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases. Ikeda S, et al. J Clin Invest, 2021 Mar 1. PMID 33373332, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RagA and RagB are key regulators of lysosomal function and cardiac protection.
    Title: Rag GTPases are cardioprotective by regulating lysosomal function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC69750, MGC95567

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl ribonucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to leucine starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related GTP-binding protein B
Names
rag B
ragB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004154.2 → NP_001004154.1  ras-related GTP-binding protein B

    See identical proteins and their annotated locations for NP_001004154.1

    Status: VALIDATED

    Source sequence(s)
    BC069180, BC070407, BY123210
    Consensus CDS
    CCDS30480.1
    UniProtKB/Swiss-Prot
    B1AVD6, Q6NTA4
    Related
    ENSMUSP00000039013.5, ENSMUST00000039720.11
    Conserved Domains (1) summary
    cd11384
    Location:42 → 353
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    151920640..151973188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528850.4 → XP_006528913.1  ras-related GTP-binding protein B isoform X2

    Conserved Domains (1) summary
    cd11384
    Location:42 → 344
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

  2. XM_036161969.1 → XP_036017862.1  ras-related GTP-binding protein B isoform X4

    Conserved Domains (1) summary
    cd11384
    Location:42 → 316
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

  3. XM_006528851.4 → XP_006528914.1  ras-related GTP-binding protein B isoform X3

    Conserved Domains (1) summary
    cd11384
    Location:42 → 321
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

  4. XM_006528849.5 → XP_006528912.1  ras-related GTP-binding protein B isoform X1

    See identical proteins and their annotated locations for XP_006528912.1

    Conserved Domains (1) summary
    cd11384
    Location:42 → 325
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

  5. XM_030251348.1 → XP_030107208.1  ras-related GTP-binding protein B isoform X5

    Conserved Domains (1) summary
    cd11384
    Location:42 → 293
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

  6. XM_017318502.2 → XP_017173991.1  ras-related GTP-binding protein B isoform X6

    Conserved Domains (1) summary
    cl38936
    Location:42 → 232
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_004940337.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NTA4.1 GenPept UniProtKB/Swiss-Prot:Q6NTA4

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