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Frmpd3 FERM and PDZ domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 245643, updated on 5-Mar-2024

Summary

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Official Symbol
Frmpd3provided by MGI
Official Full Name
FERM and PDZ domain containing 3provided by MGI
Primary source
MGI:MGI:3646547
See related
Ensembl:ENSMUSG00000042425 AllianceGenome:MGI:3646547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm29750; EG245643; B930041G04
Summary
Orthologous to human FRMPD3 (FERM and PDZ domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 3.7), frontal lobe adult (RPKM 3.6) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Frmpd3 in Genome Data Viewer
Location:
X F1; X
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (139177867..139336216)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (140277123..140435467)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39537 Neighboring gene predicted gene, 57672 Neighboring gene STARR-seq mESC enhancer starr_48002 Neighboring gene STARR-seq mESC enhancer starr_48003 Neighboring gene predicted gene, 32113 Neighboring gene microRNA 3475 Neighboring gene STARR-seq mESC enhancer starr_48004 Neighboring gene STARR-seq mESC enhancer starr_48005 Neighboring gene STARR-positive B cell enhancer mm9_chrX:136990945-136991245 Neighboring gene STARR-seq mESC enhancer starr_48006 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 Neighboring gene STARR-positive B cell enhancer mm9_chrX:137038534-137038835 Neighboring gene predicted gene, 39538

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
FERM and PDZ domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320946.1 → NP_001307875.1  FERM and PDZ domain-containing protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672297
    Consensus CDS
    CCDS85809.1
    UniProtKB/TrEMBL
    A0A140LIW3, A0A3G0YW97
    Related
    ENSMUSP00000146983.2, ENSMUST00000208130.2
    Conserved Domains (5) summary
    smart00295
    Location:148 → 367
    B41; Band 4.1 homologues
    PHA03307
    Location:847 → 1224
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:19 → 95
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13183
    Location:363 → 466
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd17169
    Location:145 → 237
    FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)

  2. NM_001388454.1 → NP_001375383.1  FERM and PDZ domain-containing protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL672297, AL714021
    UniProtKB/TrEMBL
    A0A140LIW3, A0A3G0YW97
    Conserved Domains (5) summary
    smart00295
    Location:148 → 367
    B41; Band 4.1 homologues
    PHA03307
    Location:847 → 1224
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00992
    Location:19 → 95
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13183
    Location:363 → 466
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd17169
    Location:145 → 237
    FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)

  3. NM_001388455.1 → NP_001375384.1  FERM and PDZ domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672297, AL714021
    UniProtKB/TrEMBL
    A0A3G0YW97
    Conserved Domains (4) summary
    smart00295
    Location:13 → 232
    B41; Band 4.1 homologues
    PHA03307
    Location:712 → 1089
    PHA03307; transcriptional regulator ICP4; Provisional
    cd13183
    Location:228 → 331
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd17169
    Location:10 → 102
    FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)

  4. NM_001388456.1 → NP_001375385.1  FERM and PDZ domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672297, AL714021
    UniProtKB/TrEMBL
    A0A3G0YW97
    Conserved Domains (4) summary
    smart00295
    Location:13 → 232
    B41; Band 4.1 homologues
    PHA03307
    Location:712 → 1089
    PHA03307; transcriptional regulator ICP4; Provisional
    cd13183
    Location:228 → 331
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd17169
    Location:10 → 102
    FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)

  5. NM_001388457.1 → NP_001375386.1  FERM and PDZ domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672297, AL714021
    UniProtKB/TrEMBL
    A0A3G0YW97
    Conserved Domains (4) summary
    smart00295
    Location:13 → 232
    B41; Band 4.1 homologues
    PHA03307
    Location:712 → 1089
    PHA03307; transcriptional regulator ICP4; Provisional
    cd13183
    Location:228 → 331
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd17169
    Location:10 → 102
    FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)

  6. NM_001388458.1 → NP_001375387.1  FERM and PDZ domain-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL672297
    UniProtKB/TrEMBL
    A0A3G0YW97
    Conserved Domains (4) summary
    smart00295
    Location:13 → 232
    B41; Band 4.1 homologues
    PHA03307
    Location:712 → 1089
    PHA03307; transcriptional regulator ICP4; Provisional
    cd13183
    Location:228 → 331
    FERM_C_FRMPD1_FRMPD3_FRMPD4; FERM domain C-lobe of FERM and PDZ domain containing proteins 1, 3, and 4 (FRMPD1, 3, 4)
    cd17169
    Location:10 → 102
    FERM_F1_FRMPD3; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in FERM and PDZ domain-containing protein 3 (FRMPD3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    139177867..139336216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528657.3 → XP_006528720.1  FERM and PDZ domain-containing protein 3 isoform X3

    See identical proteins and their annotated locations for XP_006528720.1

    Conserved Domains (3) summary
    PTZ00449
    Location:571 → 889
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03307
    Location:365 → 742
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam15449
    Location:590 → 738
    Retinal; Retinal protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177750.6: Suppressed sequence

    Description
    NM_177750.6: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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