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Tbx22 T-box 22 [ Mus musculus (house mouse) ]

Gene ID: 245572, updated on 21-Apr-2024

Summary

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Official Symbol
Tbx22provided by MGI
Official Full Name
T-box 22provided by MGI
Primary source
MGI:MGI:2389465
See related
Ensembl:ENSMUSG00000031241 AllianceGenome:MGI:2389465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D230020M15Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including 1st branchial arch mesenchyme; alimentary system; face; nose; and vibrissa follicle. Used to study X-linked cleft palate with or without ankyloglossia. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; X-linked cleft palate with or without ankyloglossia; and cleft palate. Orthologous to human TBX22 (T-box transcription factor 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
X D; X 47.59 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (106711570..106732586)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (107667964..107688980)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47744 Neighboring gene integral membrane protein 2A Neighboring gene STARR-seq mESC enhancer starr_47745 Neighboring gene GLE1 RNA export mediator pseudogene Neighboring gene STARR-seq mESC enhancer starr_47746 Neighboring gene STARR-seq mESC enhancer starr_47747 Neighboring gene STARR-seq mESC enhancer starr_47748 Neighboring gene charged multivesicular body protein 1B2 Neighboring gene terminal nucleotidyltransferase 5D Neighboring gene STARR-seq mESC enhancer starr_47749 Neighboring gene STARR-seq mESC enhancer starr_47750 Neighboring gene STARR-seq mESC enhancer starr_47751 Neighboring gene WAVE homology in membrane protrusions

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of mouse Tbx22 supports its role in palatogenesis and glossogenesis. Herr A, et al. Dev Dyn, 2003 Apr. PMID 12666195
  2. Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene. Bush JO, et al. Dev Dyn, 2002 Nov. PMID 12412015
  3. Xcat, a novel mouse model for Nance-Horan syndrome inhibits expression of the cytoplasmic-targeted Nhs1 isoform. Huang KM, et al. Hum Mol Genet, 2006 Jan 15. PMID 16357105
  4. Dorsoventral patterning of the mouse coat by Tbx15. Candille SI, et al. PLoS Biol, 2004 Jan. PMID 14737183, Free PMC Article
  5. Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients. Braybrook C, et al. Hum Mol Genet, 2002 Oct 15. PMID 12374769

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results demonstrate that FGF8 induces Tbx22 in the early face while BMP4 represses and thus restricts its expression. This regulation is conserved between chicken and mouse.
    Title: Regulation of Tbx22 during facial and palatal development.
  2. Data show that Tbx22 is an important determinant for intramembranous bone formation in the posterior hard palate, which underpins normal palate development and function.
    Title: Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes.
  3. Mn1 and Tbx22 function in a novel molecular pathway regulating mammalian palate development.
    Title: The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice.
  4. Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia (CPX) phenotype observed in CPX patients.
    Title: Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia phenotype observed in CPX patients.
  5. In mouse embryos, it is expressed in distinct areas of the head, namely the mesenchyme of the inferior nasal septum, the posterior palatal shelf before fusion, the attachment of the tongue, and mesenchymal cells surrounding the eye anlage.
    Title: Expression of mouse Tbx22 supports its role in palatogenesis and glossogenesis.
  6. primary role for Tbx22 in both palate and tongue development
    Title: Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
T-box transcription factor TBX22
Names
T-box protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290747.1 → NP_001277676.1  T-box transcription factor TBX22 isoform 3

    See identical proteins and their annotated locations for NP_001277676.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF516208, AK053430, BB375235, BC152402
    Consensus CDS
    CCDS72420.1
    UniProtKB/TrEMBL
    Q8BKE4
    Related
    ENSMUSP00000127321.2, ENSMUST00000168403.2
    Conserved Domains (1) summary
    cl00145
    Location:7 → 82
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

  2. NM_145224.3 → NP_660259.1  T-box transcription factor TBX22 isoform 1

    See identical proteins and their annotated locations for NP_660259.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes isoform 1.
    Source sequence(s)
    AF516208, AK084312, AL663048
    Consensus CDS
    CCDS30350.1
    UniProtKB/Swiss-Prot
    Q8K402
    UniProtKB/TrEMBL
    Q811Z5
    Related
    ENSMUSP00000112544.2, ENSMUST00000118986.8
    Conserved Domains (1) summary
    cd00182
    Location:89 → 284
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

  3. NM_181319.5 → NP_851836.2  T-box transcription factor TBX22 isoform 2

    See identical proteins and their annotated locations for NP_851836.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (2) has a longer N-terminus than isoform 1.
    Source sequence(s)
    AF516208
    Consensus CDS
    CCDS30351.2
    UniProtKB/TrEMBL
    E9Q5R8, Q811Z5
    Related
    ENSMUSP00000128247.3, ENSMUST00000168174.9
    Conserved Domains (1) summary
    cd00182
    Location:103 → 298
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    106711570..106732586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318490.3 → XP_017173979.1  T-box transcription factor TBX22 isoform X1

    UniProtKB/TrEMBL
    Q811Z5
    Conserved Domains (1) summary
    cd00182
    Location:90 → 285
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

  2. XM_017318491.3 → XP_017173980.1  T-box transcription factor TBX22 isoform X2

    UniProtKB/Swiss-Prot
    Q8K402
    UniProtKB/TrEMBL
    Q811Z5
    Conserved Domains (1) summary
    cd00182
    Location:89 → 284
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

  3. XM_017318492.3 → XP_017173981.1  T-box transcription factor TBX22 isoform X3

    UniProtKB/TrEMBL
    Q811Z5
    Conserved Domains (1) summary
    cd00182
    Location:1 → 167
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

  4. XM_006528040.5 → XP_006528103.1  T-box transcription factor TBX22 isoform X4

    See identical proteins and their annotated locations for XP_006528103.1

    Conserved Domains (1) summary
    cl00145
    Location:1 → 126
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

  5. XM_006528039.4 → XP_006528102.1  T-box transcription factor TBX22 isoform X4

    See identical proteins and their annotated locations for XP_006528102.1

    Conserved Domains (1) summary
    cl00145
    Location:1 → 126
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

  6. XM_036161956.1 → XP_036017849.1  T-box transcription factor TBX22 isoform X5

    Conserved Domains (1) summary
    cl00145
    Location:1 → 67
    T-box; DNA-binding domain of the T-box transcription factor family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K402.1 GenPept UniProtKB/Swiss-Prot:Q8K402

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