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Eda2r ectodysplasin A2 receptor [ Mus musculus (house mouse) ]

Gene ID: 245527, updated on 11-Apr-2024

Summary

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Official Symbol
Eda2rprovided by MGI
Official Full Name
ectodysplasin A2 receptorprovided by MGI
Primary source
MGI:MGI:2442860
See related
Ensembl:ENSMUSG00000034457 AllianceGenome:MGI:2442860
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Xedar; TNFRSF27; 9430060M22Rik
Summary
Predicted to enable signaling receptor activity. Acts upstream of or within intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including genitourinary system; heart; integumental system; lung; and small intestine. Orthologous to human EDA2R (ectodysplasin A2 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 1.0), bladder adult (RPKM 0.7) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X C3; X 42.74 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (96375936..96420786, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (97333837..97377234, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47588 Neighboring gene G protein-coupled receptor 15-like Neighboring gene STARR-seq mESC enhancer starr_47589 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47590 Neighboring gene STARR-seq mESC enhancer starr_47591 Neighboring gene STARR-seq mESC enhancer starr_47592 Neighboring gene Kruppel-like factor 17 pseudogene Neighboring gene nuclear encoded tRNA lysine 33 (anticodon CTT) Neighboring gene STARR-seq mESC enhancer starr_47593 Neighboring gene mitochondrial ribosomal protein L10 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EDA2R mediates podocyte injury in high glucose milieu. Lan X, et al. Biochimie, 2020 Jul. PMID 32304771, Free PMC Article
  2. Ectodysplasin-A2 induces apoptosis in cultured human hair follicle cells and promotes regression of hair follicles in mice. Kwack MH, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31607478
  3. Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency. Newton K, et al. Mol Cell Biol, 2004 Feb. PMID 14749376, Free PMC Article
  4. EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia. Bilgic SN, et al. Nature, 2023 May. PMID 37165186
  5. p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss. Brosh R, et al. FEBS Lett, 2010 Jun 3. PMID 20434500

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ectodysplasin Signaling through XEDAR Is Required for Mammary Gland Morphogenesis.
    Title: Ectodysplasin Signaling through XEDAR Is Required for Mammary Gland Morphogenesis.
  2. EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.
    Title: EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia.
  3. EDA2R mediates podocyte injury in high glucose milieu.
    Title: EDA2R mediates podocyte injury in high glucose milieu.
  4. High expression of EDA2R in the late anagen phase of hair growth.
    Title: Ectodysplasin-A2 induces apoptosis in cultured human hair follicle cells and promotes regression of hair follicles in mice.
  5. EDA-A2 transgenic mice exhibited multifocal myodegeneration; this phenotype was not observed in the absence of XEDAR
    Title: Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency.
  6. isoforms of EDA-A5 and A5',activated NF-kappaB through receptors EDAR and XEDAR
    Title: Repertoire of mouse ectodysplasin-A (EDA-A) isoforms.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124099

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables tumor necrosis factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within programmed cell death RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 27
Names
EDA-A2 receptor
X linked ectodysplasin receptor
X-linked ectodysplasin-A2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161432.2 → NP_001154904.1  tumor necrosis factor receptor superfamily member 27

    See identical proteins and their annotated locations for NP_001154904.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AL732487
    Consensus CDS
    CCDS30293.1
    UniProtKB/Swiss-Prot
    Q8BM50, Q8BX35
    UniProtKB/TrEMBL
    Q3KP88
    Related
    ENSMUSP00000109463.2, ENSMUST00000113832.2
    Conserved Domains (1) summary
    cd15838
    Location:3 → 118
    TNFRSF27; Tumor necrosis factor receptor superfamily member 27 (TNFRSF27), also known as ectodysplasin A2 receptor (EDA2R) or X-linked ectodermal dysplasia receptor (XEDAR)

  2. NM_001161433.2 → NP_001154905.1  tumor necrosis factor receptor superfamily member 27

    See identical proteins and their annotated locations for NP_001154905.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AL732487
    Consensus CDS
    CCDS30293.1
    UniProtKB/Swiss-Prot
    Q8BM50, Q8BX35
    UniProtKB/TrEMBL
    Q3KP88
    Related
    ENSMUST00000126283.8
    Conserved Domains (1) summary
    cd15838
    Location:3 → 118
    TNFRSF27; Tumor necrosis factor receptor superfamily member 27 (TNFRSF27), also known as ectodysplasin A2 receptor (EDA2R) or X-linked ectodermal dysplasia receptor (XEDAR)

  3. NM_175540.6 → NP_780749.3  tumor necrosis factor receptor superfamily member 27

    See identical proteins and their annotated locations for NP_780749.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AL732487
    Consensus CDS
    CCDS30293.1
    UniProtKB/Swiss-Prot
    Q8BM50, Q8BX35
    UniProtKB/TrEMBL
    Q3KP88
    Related
    ENSMUSP00000041210.4, ENSMUST00000037353.10
    Conserved Domains (1) summary
    cd15838
    Location:3 → 118
    TNFRSF27; Tumor necrosis factor receptor superfamily member 27 (TNFRSF27), also known as ectodysplasin A2 receptor (EDA2R) or X-linked ectodermal dysplasia receptor (XEDAR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    96375936..96420786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BX35.1 GenPept UniProtKB/Swiss-Prot:Q8BX35

Gene LinkOut

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