U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hsf3 heat shock transcription factor 3 [ Mus musculus (house mouse) ]

Gene ID: 245525, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Hsf3provided by MGI
Official Full Name
heat shock transcription factor 3provided by MGI
Primary source
MGI:MGI:3045337
See related
Ensembl:ENSMUSG00000045802 AllianceGenome:MGI:3045337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HSF 3; HSTF 3; B230358A15Rik
Summary
Enables chromatin DNA binding activity and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to heat. Located in cytoplasm and nucleus. Is expressed in eye; genital tubercle; genitourinary system; heart; and limb. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
X C3; X 42.69 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (95349781..95499900, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (96306178..96456294, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Mir223 host gene Neighboring gene microRNA 223 Neighboring gene V-set and immunoglobulin domain containing 4 Neighboring gene predicted gene, 18171 Neighboring gene STARR-seq mESC enhancer starr_47582 Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene STARR-seq mESC enhancer starr_47583 Neighboring gene hephaestin Neighboring gene ribosomal protein L17, pseudogene 8 Neighboring gene heat shock protein 1 (chaperonin) pseudogene 10

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A novel mouse HSF3 has the potential to activate nonclassical heat-shock genes during heat shock. Fujimoto M, et al. Mol Biol Cell, 2010 Jan 1. PMID 19864465, Free PMC Article
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
heat shock factor protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310754.2 → NP_001297683.1  heat shock factor protein 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL831708, AL929273
    Consensus CDS
    CCDS81156.1
    UniProtKB/Swiss-Prot
    D0VYS2, D0VYS3
    UniProtKB/TrEMBL
    E9QNK9
    Related
    ENSMUSP00000052508.5, ENSMUST00000059003.5
    Conserved Domains (2) summary
    smart00415
    Location:9 → 112
    HSF; heat shock factor
    pfam03938
    Location:128 → 178
    OmpH; Outer membrane protein (OmpH-like)

  2. NM_001310755.2 → NP_001297684.1  heat shock factor protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001297684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AL732365, AL831708, AL929273
    Consensus CDS
    CCDS85791.1
    UniProtKB/TrEMBL
    A0A0R4J251
    Related
    ENSMUSP00000132248.2, ENSMUST00000164693.8
    Conserved Domains (2) summary
    pfam00447
    Location:23 → 101
    HSF_DNA-bind; HSF-type DNA-binding
    pfam03938
    Location:117 → 167
    OmpH; Outer membrane protein (OmpH-like)

  3. NM_172931.5 → NP_766519.1  heat shock factor protein 3 isoform 2

    See identical proteins and their annotated locations for NP_766519.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AL732365, AL831708, AL929273
    Consensus CDS
    CCDS53140.1
    UniProtKB/TrEMBL
    Q8BL67
    Related
    ENSMUSP00000114018.3, ENSMUST00000119035.9
    Conserved Domains (2) summary
    pfam00447
    Location:1 → 44
    HSF_DNA-bind; HSF-type DNA-binding
    pfam03938
    Location:60 → 110
    OmpH; Outer membrane protein (OmpH-like)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    95349781..95499900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D0VYS2.1 GenPept UniProtKB/Swiss-Prot:D0VYS2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous