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Zfp300 zinc finger protein 300 [ Mus musculus (house mouse) ]

Gene ID: 245368, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp300provided by MGI
Official Full Name
zinc finger protein 300provided by MGI
Primary source
MGI:MGI:3045326
See related
Ensembl:ENSMUSG00000031079 AllianceGenome:MGI:3045326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D930016N04Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
X A1.3; X 16.59 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20944447..20955934, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (21078208..21089698, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene zinc finger protein 182 Neighboring gene STARR-seq mESC enhancer starr_46890 Neighboring gene STARR-seq mESC enhancer starr_46891 Neighboring gene sperm acrosome associated 5 Neighboring gene SSX member A1 Neighboring gene STARR-seq mESC enhancer starr_46892 Neighboring gene Na K-ATPase beta-3 subunit pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evolution of KRAB-containing zinc finger proteins and their roles in species evolution. Wang J, et al. Yi Chuan, 2016 Nov 20. PMID 27867147
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 300
Names
Novel KRAB box containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358840.1 → NP_001345769.1  zinc finger protein 300 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL671853
    Conserved Domains (3) summary
    smart00349
    Location:8 → 63
    KRAB; krueppel associated box
    COG5048
    Location:249 → 594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:386 → 406
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_183185.3 → NP_899008.2  zinc finger protein 300 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK053018, AL671853
    Consensus CDS
    CCDS30050.1
    UniProtKB/TrEMBL
    A2AE21
    Related
    ENSMUSP00000046514.7, ENSMUST00000040667.13
    Conserved Domains (6) summary
    smart00349
    Location:7 → 62
    KRAB; krueppel associated box
    COG5048
    Location:248 → 593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:385 → 405
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:554 → 576
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:7 → 46
    KRAB; KRAB box
    pfam13465
    Location:454 → 477
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    20944447..20955934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527628.4 → XP_006527691.1  zinc finger protein 300 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:8 → 63
    KRAB; krueppel associated box
    COG5048
    Location:248 → 593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:385 → 405
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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