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Prss35 serine protease 35 [ Mus musculus (house mouse) ]

Gene ID: 244954, updated on 21-Apr-2024

Summary

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Official Symbol
Prss35provided by MGI
Official Full Name
serine protease 35provided by MGI
Primary source
MGI:MGI:2444800
See related
Ensembl:ENSMUSG00000033491 AllianceGenome:MGI:2444800
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P3D9; 6030424L22Rik
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in mitochondrion. Is expressed in embryo; head; interstitium of the testis; and primary palate. Orthologous to human PRSS35 (serine protease 35). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 17.6), limb E14.5 (RPKM 14.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E3.1; 9 46.58 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (86625291..86640496)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (86743240..86758443)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene malic enzyme 1, NADP(+)-dependent, cytosolic Neighboring gene RIKEN cDNA A330041J22 gene Neighboring gene predicted gene, 22138 Neighboring gene synaptosomal-associated protein 91 Neighboring gene STARR-seq mESC enhancer starr_24841 Neighboring gene predicted gene, 39389

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fibrotic enzymes modulate wound-induced skin tumorigenesis. Van Hove L, et al. EMBO Rep, 2021 May 5. PMID 33780134, Free PMC Article
  2. Distinct spatiotemporal expression of serine proteases Prss23 and Prss35 in periimplantation mouse uterus and dispensable function of Prss35 in fertility. Diao H, et al. PLoS One, 2013. PMID 23451081, Free PMC Article
  3. Expression and localization of the serine proteases high-temperature requirement factor A1, serine protease 23, and serine protease 35 in the mouse ovary. Wahlberg P, et al. Endocrinology, 2008 Oct. PMID 18566130
  4. Novel cleft susceptibility genes in chromosome 6q. Letra A, et al. J Dent Res, 2010 Sep. PMID 20511563, Free PMC Article
  5. The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies. Miyakoshi K, et al. Biol Reprod, 2006 Dec. PMID 16870946

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The study demonstrates the distinct expression of Prss23 and Prss35 in the periimplantation uterus and the dispensable role of Prss35 in fertility and embryo development.
    Title: Distinct spatiotemporal expression of serine proteases Prss23 and Prss35 in periimplantation mouse uterus and dispensable function of Prss35 in fertility.
  2. HtrA1 and PRSS35 may be involved in ovulation and corpus luteum formation and regression, and that PRSS23 may play a role in follicular atresia
    Title: Expression and localization of the serine proteases high-temperature requirement factor A1, serine protease 23, and serine protease 35 in the mouse ovary.
  3. Prss35 mRNA levels increased around the time of ovulation and remained elevated in the developing corpus luteum
    Title: The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies.
  4. Mouse ortholog of human PRSS35 is an ovary-selectively expressed gene.
    Title: The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
inactive serine protease 35
Names
protease, serine 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178738.3 → NP_848853.2  inactive serine protease 35 precursor

    See identical proteins and their annotated locations for NP_848853.2

    Status: VALIDATED

    Source sequence(s)
    BB659182, BC075675
    Consensus CDS
    CCDS40714.1
    UniProtKB/Swiss-Prot
    Q8C0D6, Q8C0F9, Q8C0L5
    Related
    ENSMUSP00000035271.7, ENSMUST00000036426.13
    Conserved Domains (1) summary
    cl21584
    Location:124 → 389
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    86625291..86640496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155009.1 → XP_036010902.1  inactive serine protease 35 isoform X1

    UniProtKB/Swiss-Prot
    Q8C0D6, Q8C0F9, Q8C0L5
    Conserved Domains (1) summary
    cl21584
    Location:124 → 389
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. XM_006511170.5 → XP_006511233.1  inactive serine protease 35 isoform X1

    See identical proteins and their annotated locations for XP_006511233.1

    UniProtKB/Swiss-Prot
    Q8C0D6, Q8C0F9, Q8C0L5
    Conserved Domains (1) summary
    cl21584
    Location:124 → 389
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. XM_006511171.5 → XP_006511234.1  inactive serine protease 35 isoform X1

    See identical proteins and their annotated locations for XP_006511234.1

    UniProtKB/Swiss-Prot
    Q8C0D6, Q8C0F9, Q8C0L5
    Conserved Domains (1) summary
    cl21584
    Location:124 → 389
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0F9.1 GenPept UniProtKB/Swiss-Prot:Q8C0F9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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