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Klhl31 kelch-like 31 [ Mus musculus (house mouse) ]

Gene ID: 244923, updated on 5-Mar-2024

Summary

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Official Symbol
Klhl31provided by MGI
Official Full Name
kelch-like 31provided by MGI
Primary source
MGI:MGI:3045305
See related
Ensembl:ENSMUSG00000044938 AllianceGenome:MGI:3045305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kbtbd1; 9830147P19Rik; D930047P17Rik
Summary
Predicted to be involved in negative regulation of JNK cascade and negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. Is expressed in axial skeleton; diaphragm; forearm rest of mesenchyme; and skeletal musculature. Used to study centronuclear myopathy. Orthologous to human KLHL31 (kelch like family member 31). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 11.5), mammary gland adult (RPKM 5.8) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E1; 9 43.36 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (77544014..77567407)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (77636732..77660125)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:77317674-77317857 Neighboring gene leucine rich repeat containing 1 Neighboring gene STARR-seq mESC enhancer starr_24696 Neighboring gene STARR-seq mESC enhancer starr_24697 Neighboring gene STARR-seq mESC enhancer starr_24699 Neighboring gene STARR-positive B cell enhancer mm9_chr9:77398917-77399217 Neighboring gene STARR-seq mESC enhancer starr_24700 Neighboring gene chimerin (chimaerin) 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:77440338-77440521 Neighboring gene STARR-positive B cell enhancer ABC_E2905 Neighboring gene STARR-seq mESC enhancer starr_24701 Neighboring gene STARR-seq mESC enhancer starr_24702 Neighboring gene STARR-positive B cell enhancer ABC_E6770 Neighboring gene STARR-seq mESC enhancer starr_24703 Neighboring gene STARR-seq mESC enhancer starr_24704 Neighboring gene STARR-positive B cell enhancer ABC_E3846 Neighboring gene glutamate-cysteine ligase, catalytic subunit Neighboring gene STARR-seq mESC enhancer starr_24706 Neighboring gene predicted gene, 34654

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficiency in Kelch protein Klhl31 causes congenital myopathy in mice. Papizan JB, et al. J Clin Invest, 2017 Oct 2. PMID 28872460, Free PMC Article
  2. A novel human BTB-kelch protein KLHL31, strongly expressed in muscle and heart, inhibits transcriptional activities of TRE and SRE. Yu W, et al. Mol Cells, 2008 Nov 30. PMID 18719355
  3. A novel zebrafish kelchlike gene klhl and its human ortholog KLHL display conserved expression patterns in skeletal and cardiac muscles. Wu YL, et al. Gene, 2004 Aug 18. PMID 15302408
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in negative regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 31
Names
kelch repeat and BTB (POZ) domain containing 1
kelch repeat and BTB domain-containing protein 1
kelch-like protein KLHL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172925.2 → NP_766513.2  kelch-like protein 31

    See identical proteins and their annotated locations for NP_766513.2

    Status: VALIDATED

    Source sequence(s)
    AK053085, CT030709
    Consensus CDS
    CCDS23352.1
    UniProtKB/Swiss-Prot
    Q148Q5, Q8BWA5
    UniProtKB/TrEMBL
    G3X9D8
    Related
    ENSMUSP00000059643.7, ENSMUST00000057781.8
    Conserved Domains (6) summary
    smart00612
    Location:420 → 466
    Kelch; Kelch domain
    PHA03098
    Location:73 → 601
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:356 → 405
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:63 → 164
    BTB; BTB/POZ domain
    pfam01344
    Location:502 → 552
    Kelch_1; Kelch motif
    pfam07707
    Location:172 → 273
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    77544014..77567407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177238.2: Suppressed sequence

    Description
    NM_177238.2: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BWA5.1 GenPept UniProtKB/Swiss-Prot:Q8BWA5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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