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Peak1 pseudopodium-enriched atypical kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 244895, updated on 21-Apr-2024

Summary

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Official Symbol
Peak1provided by MGI
Official Full Name
pseudopodium-enriched atypical kinase 1provided by MGI
Primary source
MGI:MGI:2442366
See related
Ensembl:ENSMUSG00000074305 AllianceGenome:MGI:2442366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SGK269; mKIAA2002; 9530046P14; 1110049L02Rik; C230081A13Rik
Summary
Predicted to enable identical protein binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in several processes, including focal adhesion assembly; regulation of focal adhesion assembly; and substrate adhesion-dependent cell spreading. Located in actin cytoskeleton and focal adhesion. Orthologous to human PEAK1 (pseudopodium enriched atypical kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 5.8), cerebellum adult (RPKM 5.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 B; 9 30.13 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56108410..56325972, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56201126..56418222, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55937639-55937826 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55938770-55938923 Neighboring gene STARR-positive B cell enhancer ABC_E10547 Neighboring gene STARR-seq mESC enhancer starr_24202 Neighboring gene proline-serine-threonine phosphatase-interacting protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55994441-55994594 Neighboring gene STARR-positive B cell enhancer ABC_E6737 Neighboring gene tetraspanin 3 Neighboring gene STARR-positive B cell enhancer mm9_chr9:56112222-56112523 Neighboring gene pseudopodium-enriched atypical kinase 1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_24203 Neighboring gene STARR-seq mESC enhancer starr_24204 Neighboring gene STARR-positive B cell enhancer ABC_E1385 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56266337-56266490 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56266643-56266962 Neighboring gene high mobility group 20A Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56313127-56313350 Neighboring gene ubiquitin-conjugating enzyme E2S, retrotransposed Neighboring gene STARR-seq mESC enhancer starr_24205 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56354440-56354627 Neighboring gene predicted gene, 53524

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Wang H, et al. Cell Discov, 2018. PMID 29872538, Free PMC Article
  2. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Wang Y, et al. Proc Natl Acad Sci U S A, 2010 Jun 15. PMID 20534451, Free PMC Article
  3. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Caenepeel S, et al. Proc Natl Acad Sci U S A, 2004 Aug 10. PMID 15289607, Free PMC Article
  4. The protein kinase complement of the human genome. Manning G, et al. Science, 2002 Dec 6. PMID 12471243
  5. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inactive tyrosine-protein kinase PEAK1
Names
NKF3 kinase family member
sugen kinase 269
tyrosine-protein kinase SgK269
NP_766512.2
XP_006511230.1
XP_006511231.1
XP_036010901.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172924.3 → NP_766512.2  inactive tyrosine-protein kinase PEAK1

    See identical proteins and their annotated locations for NP_766512.2

    Status: VALIDATED

    Source sequence(s)
    AC160935, AK004211, AK035440, AK048912, AK173328, AW457766, CJ186507
    Consensus CDS
    CCDS52804.1
    UniProtKB/Swiss-Prot
    E9QKY2, Q69Z38, Q8BX56, Q8R365
    Related
    ENSMUSP00000109901.3, ENSMUST00000061552.15
    Conserved Domains (2) summary
    pfam05109
    Location:475 → 853
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl21453
    Location:1492 → 1657
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    56108410..56325972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155008.1 → XP_036010901.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    UniProtKB/Swiss-Prot
    E9QKY2, Q69Z38, Q8BX56, Q8R365
    Conserved Domains (2) summary
    pfam05109
    Location:475 → 853
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl21453
    Location:1492 → 1657
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006511168.5 → XP_006511231.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    See identical proteins and their annotated locations for XP_006511231.1

    UniProtKB/Swiss-Prot
    E9QKY2, Q69Z38, Q8BX56, Q8R365
    Conserved Domains (2) summary
    pfam05109
    Location:475 → 853
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl21453
    Location:1492 → 1657
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006511167.5 → XP_006511230.1  inactive tyrosine-protein kinase PEAK1 isoform X1

    See identical proteins and their annotated locations for XP_006511230.1

    UniProtKB/Swiss-Prot
    E9QKY2, Q69Z38, Q8BX56, Q8R365
    Conserved Domains (2) summary
    pfam05109
    Location:475 → 853
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl21453
    Location:1492 → 1657
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69Z38.4 GenPept UniProtKB/Swiss-Prot:Q69Z38

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