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Scaper S phase cyclin A-associated protein in the ER [ Mus musculus (house mouse) ]

Gene ID: 244891, updated on 5-Mar-2024

Summary

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Official Symbol
Scaperprovided by MGI
Official Full Name
S phase cyclin A-associated protein in the ERprovided by MGI
Primary source
MGI:MGI:1925976
See related
Ensembl:ENSMUSG00000034007 AllianceGenome:MGI:1925976
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp291; C430017I08; D530014O03Rik
Summary
Predicted to be located in cytosol and nuclear speck. Is expressed in brain; early conceptus; eye; and genitourinary system. Orthologous to human SCAPER (S-phase cyclin A associated protein in the ER). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 5.9), CNS E18 (RPKM 5.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 B; 9 30.13 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55457163..55845505, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (55549879..55938221, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24191 Neighboring gene STARR-seq mESC enhancer starr_24192 Neighboring gene predicted gene 5917 Neighboring gene predicted gene, 23407 Neighboring gene insulin related protein 2 (islet 2) Neighboring gene STARR-seq mESC enhancer starr_24193 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr9:55546201-55546502 Neighboring gene predicted gene, 39342 Neighboring gene STARR-seq mESC enhancer starr_24195 Neighboring gene STARR-positive B cell enhancer ABC_E6735 Neighboring gene STARR-seq mESC enhancer starr_24197 Neighboring gene RIKEN cDNA 4930563M21 gene Neighboring gene ring finger protein 19A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Male sterility and reduced female fertility in SCAPER-deficient mice. Tatour Y, et al. Hum Mol Genet, 2020 Aug 3. PMID 32510560
  2. Mutations in SCAPER cause autosomal recessive retinitis pigmentosa with intellectual disability. Tatour Y, et al. J Med Genet, 2017 Sep 18. PMID 28794130
  3. Sonic hedgehog signaling regulates actin cytoskeleton via Tiam1-Rac1 cascade during spine formation. Sasaki N, et al. Mol Cell Neurosci, 2010 Dec. PMID 20654717
  4. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Mulligan MK, et al. Proc Natl Acad Sci U S A, 2006 Apr 18. PMID 16618939, Free PMC Article
  5. A neurogenomics approach to gene expression analysis in the developing brain. Jensen P, et al. Brain Res Mol Brain Res, 2004 Dec 20. PMID 15582152

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Male sterility and reduced female fertility in SCAPER-deficient mice.
    Title: Male sterility and reduced female fertility in SCAPER-deficient mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within antral ovarian follicle growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within seminiferous tubule development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ooplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm head IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
S phase cyclin A-associated protein in the endoplasmic reticulum
Names
zinc finger protein 291

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081341.2 → NP_001074810.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform 1

    See identical proteins and their annotated locations for NP_001074810.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC107819, AC116699, AC159901, AC164972, CT025567
    Consensus CDS
    CCDS52802.1
    UniProtKB/TrEMBL
    F8VQ70, Q69ZJ3
    Related
    ENSMUSP00000149750.2, ENSMUST00000217647.2
    Conserved Domains (2) summary
    PTZ00121
    Location:536 → 910
    PTZ00121; MAEBL; Provisional
    pfam16501
    Location:89 → 185
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

  2. NM_001357652.1 → NP_001344581.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC107819, AC116699, AC159901, AC164972, CT025567
    Consensus CDS
    CCDS90576.1
    UniProtKB/TrEMBL
    B2RXS3, Q69ZJ3
    Related
    ENSMUSP00000149050.2, ENSMUST00000214747.2
    Conserved Domains (2) summary
    PTZ00121
    Location:530 → 904
    PTZ00121; MAEBL; Provisional
    pfam16501
    Location:89 → 185
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

  3. NM_001357653.1 → NP_001344582.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC116699, AK021288
    UniProtKB/TrEMBL
    Q8C1F7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    55457163..55845505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244383.1 → XP_030100243.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X2

    UniProtKB/TrEMBL
    B2RXS3, Q69ZJ3
    Conserved Domains (2) summary
    PTZ00121
    Location:530 → 904
    PTZ00121; MAEBL; Provisional
    pfam16501
    Location:89 → 185
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

  2. XM_011242747.3 → XP_011241049.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X1

    See identical proteins and their annotated locations for XP_011241049.1

    UniProtKB/TrEMBL
    F8VQ70, Q69ZJ3
    Conserved Domains (2) summary
    PTZ00121
    Location:536 → 910
    PTZ00121; MAEBL; Provisional
    pfam16501
    Location:89 → 185
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

  3. XM_030244384.1 → XP_030100244.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X2

    UniProtKB/TrEMBL
    B2RXS3, Q69ZJ3
    Conserved Domains (2) summary
    PTZ00121
    Location:530 → 904
    PTZ00121; MAEBL; Provisional
    pfam16501
    Location:89 → 185
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

  4. XM_011242748.4 → XP_011241050.1  S phase cyclin A-associated protein in the endoplasmic reticulum isoform X1

    See identical proteins and their annotated locations for XP_011241050.1

    UniProtKB/TrEMBL
    F8VQ70, Q69ZJ3
    Conserved Domains (2) summary
    PTZ00121
    Location:536 → 910
    PTZ00121; MAEBL; Provisional
    pfam16501
    Location:89 → 185
    SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175536.2: Suppressed sequence

    Description
    NM_175536.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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