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Tmem266 transmembrane protein 266 [ Mus musculus (house mouse) ]

Gene ID: 244886, updated on 11-Apr-2024

Summary

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Official Symbol
Tmem266provided by MGI
Official Full Name
transmembrane protein 266provided by MGI
Primary source
MGI:MGI:2142980
See related
Ensembl:ENSMUSG00000032313 AllianceGenome:MGI:2142980
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HVRP1; 9630029F15
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in ion transport and transmembrane transport. Predicted to be located in cytosol; dendrite; and plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human TMEM266 (transmembrane protein 266). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 10.2), ovary adult (RPKM 2.6) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem266 in Genome Data Viewer
Location:
9 B; 9 29.98 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55234194..55345629)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (55326913..55438345)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene F-box protein 22 Neighboring gene neuregulin 4 Neighboring gene serpine1 mRNA binding protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9762 Neighboring gene STARR-seq mESC enhancer starr_24189 Neighboring gene VISTA enhancer mm1754 Neighboring gene STARR-seq mESC enhancer starr_24190 Neighboring gene electron transferring flavoprotein, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E11406 Neighboring gene STARR-seq mESC enhancer starr_24191 Neighboring gene predicted gene 5917

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Insight into the function of a unique voltage-sensor protein (TMEM266) and its short form in mouse cerebellum. Kawai T, et al. Biochem J, 2022 Jun 17. PMID 35574701
  2. Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1. Kim IH, et al. PLoS One, 2014. PMID 25165868, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 266
Names
Hv1 related protein 1
transmembrane protein C15orf27 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357568.2 → NP_001344497.1  transmembrane protein 266 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    CT025532
    Conserved Domains (1) summary
    pfam00520
    Location:1 → 93
    Ion_trans; Ion transport protein

  2. NM_001421582.1 → NP_001408511.1  transmembrane protein 266 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT025532

  3. NM_172923.5 → NP_766511.1  transmembrane protein 266 isoform 1

    See identical proteins and their annotated locations for NP_766511.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CT025532
    Consensus CDS
    CCDS23203.1
    UniProtKB/Swiss-Prot
    B1B1B3, Q6NVG3, Q8BZB3
    Related
    ENSMUSP00000034862.5, ENSMUST00000034862.5
    Conserved Domains (1) summary
    pfam00520
    Location:133 → 218
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    55234194..55345629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155007.1 → XP_036010900.1  transmembrane protein 266 isoform X3

  2. XM_030244382.2 → XP_030100242.1  transmembrane protein 266 isoform X3

  3. XM_036155005.1 → XP_036010898.1  transmembrane protein 266 isoform X1

    Conserved Domains (1) summary
    pfam00520
    Location:35 → 153
    Ion_trans; Ion transport protein

  4. XM_030244380.2 → XP_030100240.1  transmembrane protein 266 isoform X1

    Conserved Domains (1) summary
    pfam00520
    Location:35 → 153
    Ion_trans; Ion transport protein

  5. XM_036155006.1 → XP_036010899.1  transmembrane protein 266 isoform X3

  6. XM_006511161.4 → XP_006511224.1  transmembrane protein 266 isoform X1

    See identical proteins and their annotated locations for XP_006511224.1

    Conserved Domains (1) summary
    pfam00520
    Location:35 → 153
    Ion_trans; Ion transport protein

  7. XM_030244379.2 → XP_030100239.1  transmembrane protein 266 isoform X1

    Conserved Domains (1) summary
    pfam00520
    Location:35 → 153
    Ion_trans; Ion transport protein

  8. XM_006511164.1 → XP_006511227.1  transmembrane protein 266 isoform X2

    See identical proteins and their annotated locations for XP_006511227.1

    Conserved Domains (1) summary
    pfam00520
    Location:1 → 93
    Ion_trans; Ion transport protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZB3.3 GenPept UniProtKB/Swiss-Prot:Q8BZB3

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