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Ankk1 ankyrin repeat and kinase domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 244859, updated on 5-Mar-2024

Summary

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Official Symbol
Ankk1provided by MGI
Official Full Name
ankyrin repeat and kinase domain containing 1provided by MGI
Primary source
MGI:MGI:3045301
See related
Ensembl:ENSMUSG00000032257 AllianceGenome:MGI:3045301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9930020N01Rik
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Acts upstream of or within regulation of cell cycle process. Located in cell projection; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver. Orthologous to human ANKK1 (ankyrin repeat and kinase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
9 A5.3; 9 26.83 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (49326494..49338341, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (49415194..49427041, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 4894 Neighboring gene STARR-seq mESC enhancer starr_24090 Neighboring gene STARR-seq mESC enhancer starr_24091 Neighboring gene dopamine receptor D2 Neighboring gene predicted gene, 46111 Neighboring gene STARR-seq mESC enhancer starr_24092 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:49297299-49297500 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:49297697-49297806 Neighboring gene tetratricopeptide repeat domain 12 Neighboring gene neural cell adhesion molecule 1 Neighboring gene predicted gene 11149

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ANKK1 gene associated with addictions is expressed in astroglial cells and upregulated by apomorphine. Hoenicka J, et al. Biol Psychiatry, 2010 Jan 1. PMID 19853839
  2. ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism. Rubio-Solsona E, et al. PLoS One, 2018. PMID 29758057, Free PMC Article
  3. The Addiction-Related Protein ANKK1 is Differentially Expressed During the Cell Cycle in Neural Precursors. España-Serrano L, et al. Cereb Cortex, 2017 May 1. PMID 27166167
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell cycle process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of cell cycle process ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
ankyrin repeat and protein kinase domain-containing protein 1
NP_001363880.1
NP_766510.1
XP_036010896.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376951.1 → NP_001363880.1  ankyrin repeat and protein kinase domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC167980
    UniProtKB/TrEMBL
    B7ZN83
    Conserved Domains (4) summary
    PHA02876
    Location:364 → 694
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:403 → 434
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:672 → 742
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:37 → 305
    PKc_like; Protein Kinases, catalytic domain

  2. NM_172922.4 → NP_766510.1  ankyrin repeat and protein kinase domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_766510.1

    Status: VALIDATED

    Source sequence(s)
    AC167980
    Consensus CDS
    CCDS40616.1
    UniProtKB/Swiss-Prot
    Q8BZ25
    Related
    ENSMUSP00000034792.6, ENSMUST00000034792.7
    Conserved Domains (4) summary
    PHA02876
    Location:333 → 693
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:402 → 433
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:671 → 741
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:37 → 305
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    49326494..49338341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155003.1 → XP_036010896.1  ankyrin repeat and protein kinase domain-containing protein 1 isoform X1

    Conserved Domains (4) summary
    PHA02876
    Location:286 → 646
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:355 → 386
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:624 → 694
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:28 → 258
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZ25.1 GenPept UniProtKB/Swiss-Prot:Q8BZ25

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