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Bsx brain specific homeobox [ Mus musculus (house mouse) ]

Gene ID: 244813, updated on 21-Apr-2024

Summary

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Official Symbol
Bsxprovided by MGI
Official Full Name
brain specific homeoboxprovided by MGI
Primary source
MGI:MGI:2669849
See related
Ensembl:ENSMUSG00000054360 AllianceGenome:MGI:2669849
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bsx1a; Bsx1b
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including eating behavior; mammary gland involution; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in brain; metanephros; and renal vasculature. Orthologous to human BSX (brain specific homeobox). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
9 A5.1; 9 21.65 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (40782994..40790258)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (40874127..40878962)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8284 Neighboring gene small nucleolar RNA, C/D box 14D Neighboring gene small nucleolar RNA, C/D box 14E Neighboring gene heat shock protein 8 Neighboring gene STARR-seq mESC enhancer starr_23873 Neighboring gene junctional cadherin complex regulator Neighboring gene ubiquitin specific peptidase 10 pseudogene Neighboring gene cytotoxic and regulatory T cell molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. REST is a key regulator in brain-specific homeobox gene expression during neuronal differentiation. Park SY, et al. J Neurochem, 2007 Dec. PMID 17944879
  2. Role of homeobox genes in the hypothalamic development and energy balance. Kaji T, et al. Front Biosci (Landmark Ed), 2013 Jan 1. PMID 23276958
  3. Cloning and functional analysis of hypothalamic homeobox gene Bsx1a and its isoform, Bsx1b. Chu HY, et al. Mol Cell Biol, 2007 May. PMID 17353277, Free PMC Article
  4. Brain-specific homeobox factor as a target selector for glucocorticoid receptor in energy balance. Lee B, et al. Mol Cell Biol, 2013 Jul. PMID 23671185, Free PMC Article
  5. A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior. Sakkou M, et al. Cell Metab, 2007 Jun. PMID 17550780

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Agouti related peptide is a common orexigenic target gene of glucocorticoid receptor and Bsx in the mouse hypothalamus.
    Title: Brain-specific homeobox factor as a target selector for glucocorticoid receptor in energy balance.
  2. Bsx and TTF-1 are transcriptional factors of NPY and AgRP in the arcuate nucleus[review]
    Title: Role of homeobox genes in the hypothalamic development and energy balance.
  3. binding of REST to neuron restrictive silencer element suppresses transcriptional activator Sp1-mediated activation of bsx in non-neuronal cells
    Title: REST is a key regulator in brain-specific homeobox gene expression during neuronal differentiation.
  4. Data demonstrate that BSX1A is a DNA binding protein and a transcriptional activator, and that BSX1A and BSX1B localize in the nuclei and cytoplasm, respectively.
    Title: Cloning and functional analysis of hypothalamic homeobox gene Bsx1a and its isoform, Bsx1b.
  5. Might be considered an important molecular marker for early embryonic stages of epiphysis development.
    Title: Bsx, an evolutionary conserved Brain Specific homeoboX gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus.
  6. These results demonstrate that Bsx is required for postnatal growth and maintenance of lactating mammary glands.
    Title: A brain-specific homeobox gene, Bsx, is essential for proper postnatal growth and nursing.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC129478, MGC129479

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within eating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mammary gland involution IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
brain-specific homeobox protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178245.3 → NP_839976.1  brain-specific homeobox protein homolog

    See identical proteins and their annotated locations for NP_839976.1

    Status: PROVISIONAL

    Source sequence(s)
    AC158355
    Consensus CDS
    CCDS23084.1
    UniProtKB/Swiss-Prot
    Q3SXB1, Q810B3
    Related
    ENSMUSP00000068057.4, ENSMUST00000067375.5
    Conserved Domains (1) summary
    pfam00046
    Location:114 → 167
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    40782994..40790258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154982.1 → XP_036010875.1  brain-specific homeobox protein homolog isoform X1

    UniProtKB/Swiss-Prot
    Q3SXB1, Q810B3
    Conserved Domains (1) summary
    pfam00046
    Location:114 → 167
    Homeobox; Homeobox domain

  2. XM_006510306.1 → XP_006510369.1  brain-specific homeobox protein homolog isoform X2

    Conserved Domains (1) summary
    pfam00046
    Location:35 → 88
    Homeobox; Homeobox domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q810B3.1 GenPept UniProtKB/Swiss-Prot:Q810B3

Gene LinkOut

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