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Glb1l2 galactosidase, beta 1-like 2 [ Mus musculus (house mouse) ]

Gene ID: 244757, updated on 11-Apr-2024

Summary

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Official Symbol
Glb1l2provided by MGI
Official Full Name
galactosidase, beta 1-like 2provided by MGI
Primary source
MGI:MGI:2388283
See related
Ensembl:ENSMUSG00000036395 AllianceGenome:MGI:2388283
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable beta-galactosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in extracellular region. Predicted to be active in vacuole. Is expressed in foregut-midgut junction; molar; nose; urinary system; and vestibulo-cochlear ganglion. Orthologous to human GLB1L2 (galactosidase beta 1 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 160.2), subcutaneous fat pad adult (RPKM 53.0) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A4; 9 11.56 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (26674338..26717769, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (26763044..26806473, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30313 Neighboring gene STARR-seq mESC enhancer starr_23611 Neighboring gene STARR-seq mESC enhancer starr_23613 Neighboring gene beta-1,3-glucuronyltransferase 1 Neighboring gene galactosidase, beta 1 like 3 Neighboring gene STARR-seq mESC enhancer starr_23614 Neighboring gene predicted gene 1110

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  2. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC47419

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-galactosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
beta-galactosidase-1-like protein 2
NP_001297697.1
NP_722498.1
XP_006510360.1
XP_006510361.1
XP_006510362.1
XP_006510363.1
XP_006510365.1
XP_006510366.1
XP_036010874.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310768.1 → NP_001297697.1  beta-galactosidase-1-like protein 2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AI324066, AK033400, AK143057, BG061307, CF737161
    Consensus CDS
    CCDS80971.1
    UniProtKB/Swiss-Prot
    Q3UPY5, Q8CFT1
    UniProtKB/TrEMBL
    E0CYE1
    Related
    ENSMUSP00000066770.7, ENSMUST00000066560.13
    Conserved Domains (1) summary
    pfam01301
    Location:53 → 366
    Glyco_hydro_35; Glycosyl hydrolases family 35

  2. NM_153803.2 → NP_722498.1  beta-galactosidase-1-like protein 2 isoform 1

    See identical proteins and their annotated locations for NP_722498.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC038479, BG061307
    Consensus CDS
    CCDS40566.1
    UniProtKB/Swiss-Prot
    Q3UPY5, Q8CFT1
    UniProtKB/TrEMBL
    A0A0R4J0L1
    Related
    ENSMUSP00000047128.8, ENSMUST00000040398.14
    Conserved Domains (1) summary
    pfam01301
    Location:69 → 382
    Glyco_hydro_35; Glycosyl hydrolases family 35

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    26674338..26717769 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510297.5 → XP_006510360.1  beta-galactosidase-1-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3UPY5, Q8CFT1
    Conserved Domains (1) summary
    pfam01301
    Location:93 → 406
    Glyco_hydro_35; Glycosyl hydrolases family 35

  2. XM_006510302.4 → XP_006510365.1  beta-galactosidase-1-like protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006510365.1

    UniProtKB/Swiss-Prot
    Q3UPY5, Q8CFT1
    Conserved Domains (1) summary
    pfam01301
    Location:60 → 373
    Glyco_hydro_35; Glycosyl hydrolases family 35

  3. XM_006510300.5 → XP_006510363.1  beta-galactosidase-1-like protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006510363.1

    UniProtKB/Swiss-Prot
    Q3UPY5, Q8CFT1
    Conserved Domains (1) summary
    pfam01301
    Location:60 → 373
    Glyco_hydro_35; Glycosyl hydrolases family 35

  4. XM_006510303.3 → XP_006510366.1  beta-galactosidase-1-like protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006510366.1

    UniProtKB/Swiss-Prot
    Q3UPY5, Q8CFT1
    Conserved Domains (1) summary
    pfam01301
    Location:60 → 373
    Glyco_hydro_35; Glycosyl hydrolases family 35

  5. XM_006510299.5 → XP_006510362.1  beta-galactosidase-1-like protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006510362.1

    UniProtKB/Swiss-Prot
    Q3UPY5, Q8CFT1
    Conserved Domains (1) summary
    pfam01301
    Location:60 → 373
    Glyco_hydro_35; Glycosyl hydrolases family 35

  6. XM_006510298.4 → XP_006510361.1  beta-galactosidase-1-like protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006510361.1

    UniProtKB/Swiss-Prot
    Q3UPY5, Q8CFT1
    Related
    ENSMUSP00000124415.2, ENSMUST00000162252.8
    Conserved Domains (1) summary
    pfam01301
    Location:60 → 373
    Glyco_hydro_35; Glycosyl hydrolases family 35

  7. XM_036154981.1 → XP_036010874.1  beta-galactosidase-1-like protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q3UPY5, Q8CFT1
    Conserved Domains (1) summary
    pfam01301
    Location:60 → 373
    Glyco_hydro_35; Glycosyl hydrolases family 35
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UPY5.1 GenPept UniProtKB/Swiss-Prot:Q3UPY5

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