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Dpy19l1 dpy-19 like C-mannosyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 244745, updated on 11-Apr-2024

Summary

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Official Symbol
Dpy19l1provided by MGI
Official Full Name
dpy-19 like C-mannosyltransferase 1provided by MGI
Primary source
MGI:MGI:1915685
See related
Ensembl:ENSMUSG00000043067 AllianceGenome:MGI:1915685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6030402K12; 1100001I19Rik
Summary
Predicted to enable mannosyltransferase activity. Predicted to be involved in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in nuclear inner membrane. Is expressed in brain; lung; metanephros; and sensory organ. Orthologous to human DPY19L1 (dpy-19 like C-mannosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 16.6), cortex adult (RPKM 15.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dpy19l1 in Genome Data Viewer
Location:
9 A4; 9 10.15 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (24323074..24414436, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (24411778..24503140, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23579 Neighboring gene neuropeptide S receptor 1 Neighboring gene STARR-seq mESC enhancer starr_23580 Neighboring gene STARR-seq mESC enhancer starr_23583 Neighboring gene predicted gene 10701 Neighboring gene predicted gene, 22380 Neighboring gene predicted gene, 57533 Neighboring gene STARR-seq mESC enhancer starr_23585 Neighboring gene dpy-19 like 2 Neighboring gene STARR-seq mESC enhancer starr_23586 Neighboring gene cysteine-rich perinuclear theca 4 Neighboring gene STARR-seq mESC enhancer starr_23587 Neighboring gene STARR-seq mESC enhancer starr_23588 Neighboring gene T-box 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endoplasmic Reticulum-Localized Transmembrane Protein Dpy19L1 Is Required for Neurite Outgrowth. Watanabe K, et al. PLoS One, 2016. PMID 27959946, Free PMC Article
  2. Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3. Shcherbakova A, et al. Proc Natl Acad Sci U S A, 2017 Mar 7. PMID 28202721, Free PMC Article
  3. Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex. Watanabe K, et al. Development, 2011 Nov. PMID 22028030, Free PMC Article
  4. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mannosylation by DPY19L1 but not DPY19L3 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface. In vertebrates, a new C-mannosyltransferase has apparently evolved to increase glycosylation of TSRs, potentially to increase the stability of the structurally essential tryptophan ladder or to provide additional adhesion functions.
    Title: Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3.
  2. Dpy19L1 is localized to the ER membrane and regulates neurite extension during development.
    Title: Endoplasmic Reticulum-Localized Transmembrane Protein Dpy19L1 Is Required for Neurite Outgrowth.
  3. Dpy19l1 is required for the proper radial migration of glutamatergic neurons, an evolutionarily conserved role for the Dpy19 family in neuronal migration.
    Title: Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein C-mannosyl-transferase DPY19L1
Names
dpy-19-like 1
dpy-19-like protein 1
probable C-mannosyltransferase DPY19L1
protein dpy-19 homolog 1
NP_001346877.1
NP_766508.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359948.1 → NP_001346877.1  protein C-mannosyl-transferase DPY19L1

    Status: VALIDATED

    Source sequence(s)
    AC102554, BU757480, CT010514
    Consensus CDS
    CCDS22931.2
    UniProtKB/Swiss-Prot
    A6X919, Q3UP31, Q8CD79
    Related
    ENSMUSP00000119986.2, ENSMUST00000142064.8
    Conserved Domains (2) summary
    pfam10034
    Location:105 → 742
    Dpy19; Q-cell neuroblast polarisation
    cl28033
    Location:11 → 91
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

  2. NM_172920.4 → NP_766508.3  protein C-mannosyl-transferase DPY19L1

    See identical proteins and their annotated locations for NP_766508.3

    Status: VALIDATED

    Source sequence(s)
    AK143845, BU757480, CD352443, CT010514
    Consensus CDS
    CCDS22931.2
    UniProtKB/Swiss-Prot
    A6X919, Q3UP31, Q8CD79
    Related
    ENSMUSP00000129575.2, ENSMUST00000170356.2
    Conserved Domains (2) summary
    pfam10034
    Location:105 → 742
    Dpy19; Q-cell neuroblast polarisation
    cl28033
    Location:11 → 91
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    24323074..24414436 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6X919.1 GenPept UniProtKB/Swiss-Prot:A6X919

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