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Olfm2 olfactomedin 2 [ Mus musculus (house mouse) ]

Gene ID: 244723, updated on 21-Apr-2024

Summary

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Official Symbol
Olfm2provided by MGI
Official Full Name
olfactomedin 2provided by MGI
Primary source
MGI:MGI:3045350
See related
Ensembl:ENSMUSG00000032172 AllianceGenome:MGI:3045350
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A030009A06Rik
Summary
Acts upstream of or within locomotory behavior and visual perception. Located in glutamatergic synapse and synaptic membrane. Part of AMPA glutamate receptor complex. Is extrinsic component of synaptic membrane. Is expressed in several structures, including central nervous system; eye; and orbito-sphenoid. Orthologous to human OLFM2 (olfactomedin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 44.2), cortex adult (RPKM 37.9) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A3; 9 7.6 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20578986..20657660, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20667690..20746333, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E458 Neighboring gene F-box and leucine-rich repeat protein 12 Neighboring gene ubiquitin-like 5 Neighboring gene peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Neighboring gene predicted gene, 39299 Neighboring gene predicted gene, 35860 Neighboring gene collagen, type V, alpha 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Olfactomedin 2 deficiency protects against diet-induced obesity. González-García I, et al. Metabolism, 2022 Apr. PMID 35026233, Free PMC Article
  2. Olfactomedin 2 Regulates Smooth Muscle Phenotypic Modulation and Vascular Remodeling Through Mediating Runt-Related Transcription Factor 2 Binding to Serum Response Factor. Shi N, et al. Arterioscler Thromb Vasc Biol, 2017 Mar. PMID 28062493, Free PMC Article
  3. Olfactomedin 2: expression in the eye and interaction with other olfactomedin domain-containing proteins. Sultana A, et al. Invest Ophthalmol Vis Sci, 2011 Apr. PMID 21228389, Free PMC Article
  4. Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice. Sultana A, et al. Exp Neurol, 2014 Nov. PMID 25218043, Free PMC Article
  5. High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Schwenk J, et al. Neuron, 2012 May 24. PMID 22632720

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that heterodimers of Olfm1 and Olfm2 interact with AMPAR more efficiently than Olfm2 homodimers and that Olfm2 plays a role in the organization of the AMPA receptor complexes.
    Title: Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice.
  2. Highly conserved OLFM2 protein may play an important role in the course of retinal and eye development.
    Title: Olfactomedin 2: expression in the eye and interaction with other olfactomedin domain-containing proteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of vascular associated smooth muscle cell dedifferentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within visual perception IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extrinsic component of postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
noelin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357635.1 → NP_001344564.1  noelin-2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC164565, AC166365
    Consensus CDS
    CCDS90507.1
    UniProtKB/TrEMBL
    A0A1L1SV46
    Related
    ENSMUSP00000151018.2, ENSMUST00000217198.2
    Conserved Domains (2) summary
    pfam02191
    Location:222 → 466
    OLF; Olfactomedin-like domain
    pfam12308
    Location:49 → 144
    Noelin-1; Neurogenesis glycoprotein

  2. NM_001357639.1 → NP_001344568.1  noelin-2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC164565, AC166365
    Consensus CDS
    CCDS90508.1
    UniProtKB/TrEMBL
    A0A1L1SQX6
    Related
    ENSMUSP00000149231.2, ENSMUST00000215999.2
    Conserved Domains (2) summary
    pfam02191
    Location:200 → 444
    OLF; Olfactomedin-like domain
    pfam12308
    Location:27 → 122
    Noelin-1; Neurogenesis glycoprotein

  3. NM_173777.4 → NP_776138.2  noelin-2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_776138.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC164565, AK037199, BE948965
    Consensus CDS
    CCDS40546.1
    UniProtKB/Swiss-Prot
    Q0VFZ0, Q0VG58, Q8BM13
    Related
    ENSMUSP00000034692.8, ENSMUST00000034692.9
    Conserved Domains (2) summary
    pfam02191
    Location:192 → 436
    OLF; Olfactomedin-like domain
    pfam12308
    Location:19 → 114
    Noelin-1; Neurogenesis glycoprotein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    20578986..20657660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244363.2 → XP_030100223.1  noelin-2 isoform X1

    Conserved Domains (2) summary
    pfam02191
    Location:187 → 431
    OLF; Olfactomedin-like domain
    pfam12308
    Location:14 → 109
    Noelin-1; Neurogenesis glycoprotein

  2. XM_030244364.2 → XP_030100224.1  noelin-2 isoform X1

    Conserved Domains (2) summary
    pfam02191
    Location:187 → 431
    OLF; Olfactomedin-like domain
    pfam12308
    Location:14 → 109
    Noelin-1; Neurogenesis glycoprotein

  3. XM_030244365.2 → XP_030100225.1  noelin-2 isoform X2

    Conserved Domains (2) summary
    pfam02191
    Location:120 → 364
    OLF; Olfactomedin-like domain
    pfam12308
    Location:1 → 42
    Noelin-1; Neurogenesis glycoprotein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BM13.2 GenPept UniProtKB/Swiss-Prot:Q8BM13

Gene LinkOut

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