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Zfp846 zinc finger protein 846 [ Mus musculus (house mouse) ]

Gene ID: 244721, updated on 8-Feb-2024

Summary

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Official Symbol
Zfp846provided by MGI
Official Full Name
zinc finger protein 846provided by MGI
Primary source
MGI:MGI:1924012
See related
Ensembl:ENSMUSG00000058192 AllianceGenome:MGI:1924012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf846; 9130221F13; 2210010B09Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in bladder; female associated reproductive structure; ovary; ureter; and urethra of female. Orthologous to human ZNF699 (zinc finger protein 699). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 2.7), CNS E14 (RPKM 2.2) and 20 other tissues See more
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Genomic context

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See Zfp846 in Genome Data Viewer
Location:
9 A3; 9 7.58 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20492595..20516706)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20581299..20605404)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 266 Neighboring gene predicted gene, 46142 Neighboring gene STARR-positive B cell enhancer ABC_E6716 Neighboring gene predicted gene, 51704 Neighboring gene F-box and leucine-rich repeat protein 12, opposite strand Neighboring gene STARR-seq mESC enhancer starr_23463 Neighboring gene F-box and leucine-rich repeat protein 12 Neighboring gene ubiquitin-like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 846

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172919.2 → NP_766507.2  zinc finger protein 846

    See identical proteins and their annotated locations for NP_766507.2

    Status: VALIDATED

    Source sequence(s)
    AK033687, BB744614, BY251235, BY726782
    Consensus CDS
    CCDS22878.2
    UniProtKB/TrEMBL
    G3X996
    Related
    ENSMUSP00000111219.3, ENSMUST00000115557.10
    Conserved Domains (6) summary
    smart00349
    Location:14 → 70
    KRAB; krueppel associated box
    COG5048
    Location:160 → 528
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:164 → 184
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:162 → 184
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 52
    KRAB; KRAB box
    pfam13465
    Location:176 → 201
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    20492595..20516706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244362.2 → XP_030100222.1  zinc finger protein 846 isoform X1

    UniProtKB/TrEMBL
    Q8BIQ2
    Conserved Domains (2) summary
    COG5048
    Location:80 → 448
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:84 → 104
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. XR_003947898.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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