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Sprtn SprT-like N-terminal domain [ Mus musculus (house mouse) ]

Gene ID: 244666, updated on 16-Mar-2024

Summary

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Official Symbol
Sprtnprovided by MGI
Official Full Name
SprT-like N-terminal domainprovided by MGI
Primary source
MGI:MGI:2685351
See related
Ensembl:ENSMUSG00000031986 AllianceGenome:MGI:2685351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm505
Summary
Predicted to enable several functions, including DNA binding activity; K63-linked polyubiquitin modification-dependent protein binding activity; and metalloendopeptidase activity. Involved in protein-DNA covalent cross-linking repair. Predicted to be located in chromatin and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Ruijs-Aalfs syndrome. Orthologous to human SPRTN (SprT-like N-terminal domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 49.2), thymus adult (RPKM 7.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Sprtn in Genome Data Viewer
Location:
8 E2; 8 72.83 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (125624612..125632903)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124897771..124906161)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16163 Neighboring gene glyceronephosphate O-acyltransferase Neighboring gene exocyst complex component 8 Neighboring gene egl-9 family hypoxia-inducible factor 1 Neighboring gene predicted gene, 46060 Neighboring gene predicted gene, 39281

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis. Maskey RS, et al. Nucleic Acids Res, 2017 May 5. PMID 28199696, Free PMC Article
  2. Spartan deficiency causes genomic instability and progeroid phenotypes. Maskey RS, et al. Nat Commun, 2014 Dec 11. PMID 25501849, Free PMC Article
  3. SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. Lopez-Mosqueda J, et al. Elife, 2016 Nov 17. PMID 27852435, Free PMC Article
  4. Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging. Huang J, et al. Mol Cell, 2020 Sep 3. PMID 32649882, Free PMC Article
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoprocessing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-DNA covalent cross-linking repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-DNA covalent cross-linking repair ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA-dependent metalloprotease SPRTN
Names
protein with SprT-like domain at the N terminus
spartan
sprT-like domain-containing protein Spartan
NP_001104611.1
XP_006531083.1
XP_036009942.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111141.2 → NP_001104611.1  DNA-dependent metalloprotease SPRTN isoform 1

    See identical proteins and their annotated locations for NP_001104611.1

    Status: VALIDATED

    Source sequence(s)
    AC139158
    Consensus CDS
    CCDS52705.1
    UniProtKB/Swiss-Prot
    B2RY42, G3X912
    Related
    ENSMUSP00000034467.6, ENSMUST00000034467.7
    Conserved Domains (2) summary
    smart00734
    Location:462 → 485
    ZnF_Rad18; Rad18-like CCHC zinc finger
    pfam10263
    Location:46 → 214
    SprT-like; SprT-like family

  2. NM_001428364.1 → NP_001415293.1  DNA-dependent metalloprotease SPRTN isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC139158

  3. NM_001428365.1 → NP_001415294.1  DNA-dependent metalloprotease SPRTN isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC139158

  4. NM_001428366.1 → NP_001415295.1  DNA-dependent metalloprotease SPRTN isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC139158

  5. NM_001428367.1 → NP_001415296.1  DNA-dependent metalloprotease SPRTN isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC139158

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    125624612..125632903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154049.1 → XP_036009942.1  DNA-dependent metalloprotease SPRTN isoform X1

    Conserved Domains (3) summary
    smart00734
    Location:419 → 442
    ZnF_Rad18; Rad18-like CCHC zinc finger
    COG5432
    Location:375 → 442
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
    cl19237
    Location:44 → 170
    DUF45; Protein of unknown function DUF45

  2. XM_006531020.5 → XP_006531083.1  DNA-dependent metalloprotease SPRTN isoform X2

    Conserved Domains (3) summary
    smart00734
    Location:375 → 398
    ZnF_Rad18; Rad18-like CCHC zinc finger
    smart00731
    Location:1 → 126
    SprT; SprT homologues
    COG5432
    Location:331 → 398
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

RNA

  1. XR_387744.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3X912.1 GenPept UniProtKB/Swiss-Prot:G3X912

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