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Mtss2 MTSS I-BAR domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 244654, updated on 11-Apr-2024

Summary

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Official Symbol
Mtss2provided by MGI
Official Full Name
MTSS I-BAR domain containing 2provided by MGI
Primary source
MGI:MGI:3039591
See related
Ensembl:ENSMUSG00000033763 AllianceGenome:MGI:3039591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ABBA; Mtss1l
Summary
Enables actin monomer binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and small GTPase binding activity. Acts upstream of or within lamellipodium organization and membrane organization. Located in several cellular components, including cortical actin cytoskeleton; lamellipodium; and ruffle. Is expressed in several structures, including central nervous system; gut; musculoskeletal system; otic capsule; and vibrissa. Orthologous to human MTSS2 (MTSS I-BAR domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 29.3), ovary adult (RPKM 22.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 57.66 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111447718..111468032)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110721108..110741401)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Vac14 homolog (S. cerevisiae) Neighboring gene nuclear encoded tRNA glycine 10 (anticodon GCC) Neighboring gene predicted gene, 53454 Neighboring gene STARR-seq mESC enhancer starr_22681 Neighboring gene interleukin 34 Neighboring gene predicted gene 15894 Neighboring gene predicted gene, 39250

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fibronectin-mediated cell spreading requires ABBA-Rac1 signaling. Zeng XC, et al. J Cell Biochem, 2013 Apr. PMID 23060091
  2. Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L. Chatzi C, et al. Elife, 2019 Jun 24. PMID 31232686, Free PMC Article
  3. ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension. Saarikangas J, et al. J Cell Sci, 2008 May 1. PMID 18413296
  4. TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability. Venuto S, et al. Cancer Lett, 2020 Mar 31. PMID 31904480
  5. Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. Saarikangas J, et al. J Cell Sci, 2011 Apr 15. PMID 21406566

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results link short-term effects of exercise to activity-dependent expression of Mtss1L, which we propose as a novel effector of activity-dependent rearrangement of synapses.
    Title: Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L.
  2. ABBA promotes cell spreading.
    Title: Fibronectin-mediated cell spreading requires ABBA-Rac1 signaling.
  3. This study identifies ABBA as a novel regulator of actin and plasma membrane dynamics in radial glial cells.
    Title: ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC79213

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin monomer binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to platelet-derived growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lamellipodium organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within membrane organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in plasma membrane organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein MTSS 2
Names
MTSS1-like protein
metastasis suppressor 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310591.2 → NP_001297520.1  protein MTSS 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC139245
    Consensus CDS
    CCDS80930.1
    UniProtKB/TrEMBL
    D3YWC9
    Related
    ENSMUSP00000115220.2, ENSMUST00000144041.8
    Conserved Domains (1) summary
    cl12013
    Location:1 → 174
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_001426715.1 → NP_001413644.1  protein MTSS 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC139245

  3. NM_001426716.1 → NP_001413645.1  protein MTSS 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC139245

  4. NM_001426717.1 → NP_001413646.1  protein MTSS 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC139245

  5. NM_001426718.1 → NP_001413647.1  protein MTSS 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC139245

  6. NM_198625.3 → NP_941027.1  protein MTSS 2 isoform 1

    See identical proteins and their annotated locations for NP_941027.1

    Status: VALIDATED

    Source sequence(s)
    AC139245
    Consensus CDS
    CCDS22664.1
    UniProtKB/Swiss-Prot
    Q6P9S0, Q8C7B7
    Related
    ENSMUSP00000050211.9, ENSMUST00000052457.15
    Conserved Domains (1) summary
    cd07643
    Location:6 → 236
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    111447718..111468032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531011.5 → XP_006531074.1  protein MTSS 2 isoform X1

    Conserved Domains (1) summary
    cd07643
    Location:6 → 239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

  2. XM_006531012.5 → XP_006531075.1  protein MTSS 2 isoform X2

    Conserved Domains (1) summary
    cd07643
    Location:6 → 239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

  3. XM_006531015.5 → XP_006531078.1  protein MTSS 2 isoform X5

    Conserved Domains (1) summary
    cd07643
    Location:6 → 239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

  4. XM_006531016.5 → XP_006531079.1  protein MTSS 2 isoform X6

    Conserved Domains (1) summary
    cd07643
    Location:6 → 239
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

  5. XM_006531017.5 → XP_006531080.1  protein MTSS 2 isoform X8

    Conserved Domains (1) summary
    cd07643
    Location:6 → 208
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

  6. XM_036154045.1 → XP_036009938.1  protein MTSS 2 isoform X9

    Conserved Domains (2) summary
    cd07643
    Location:6 → 208
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cd22060
    Location:683 → 713
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

  7. XM_036154046.1 → XP_036009939.1  protein MTSS 2 isoform X12

    Conserved Domains (2) summary
    cd07643
    Location:6 → 208
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cd22060
    Location:652 → 682
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

  8. XM_036154047.1 → XP_036009940.1  protein MTSS 2 isoform X13

    Conserved Domains (2) summary
    cd07643
    Location:6 → 208
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cd22060
    Location:651 → 681
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

  9. XM_036154048.1 → XP_036009941.1  protein MTSS 2 isoform X15

    Conserved Domains (2) summary
    cd07643
    Location:6 → 205
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cd22060
    Location:648 → 678
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

  10. XM_006531018.5 → XP_006531081.1  protein MTSS 2 isoform X10

    Conserved Domains (1) summary
    cl12013
    Location:1 → 177
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  11. XM_030243563.2 → XP_030099423.1  protein MTSS 2 isoform X11

    Conserved Domains (1) summary
    cl12013
    Location:1 → 174
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  12. XM_030243565.2 → XP_030099425.1  protein MTSS 2 isoform X16

    Conserved Domains (1) summary
    cl12013
    Location:1 → 174
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9S0.1 GenPept UniProtKB/Swiss-Prot:Q6P9S0

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